Low blood flow at onset of moderate intensity exercise does not limit muscle oxygen uptake

Michael Permin Nyberg; Stefan Peter Mortensen; Bengt Saltin; Ylva Hellsten; Jens Bangsbo

doi:10.1152/ajpregu.00730.2009

Low blood flow at onset of moderate intensity exercise does not limit muscle oxygen uptake

Michael Permin Nyberg, Stefan Peter Mortensen, Bengt Saltin, Ylva Hellsten, Jens Bangsbo

21 Citationer (Scopus)

Abstract

The effect of low blood flow at onset of moderate-intensity exercise on the rate of rise in muscle oxygen uptake was examined. Seven male subjects performed a 3.5-min one-legged knee-extensor exercise bout (24 ± 1 W, mean ± SD) without (Con) and with (double blockade; DB) arterial infusion of inhibitors of nitric oxide synthase (N^G-monomethyl-L-arginine) and cyclooxygenase (indomethacin) to inhibit the synthesis of nitric oxide and prostanoids, respectively. Leg blood flow and leg oxygen delivery throughout exercise was 25-50% lower (P < 0.05) in DB compared with Con. Leg oxygen extraction (arteriovenous O2 difference) was higher (P < 0.05) in DB than in Con (5 s: 127 ± 3 vs. 56 ± 4 ml/l), and leg oxygen uptake was not different between Con and DB during exercise. The difference between leg oxygen delivery and leg oxygen uptake was smaller (P < 0.05) during exercise in DB than in Con (5 s: 59 ± 12 vs. 262 ± 39 ml/min). The present data demonstrate that muscle blood flow and oxygen delivery can be markedly reduced without affecting muscle oxygen uptake in the initial phase of moderate-intensity exercise, suggesting that blood flow does not limit muscle oxygen uptake at the onset of exercise. Additionally, prostanoids and/or nitric oxide appear to play important roles in elevating skeletal muscle blood flow in the initial phase of exercise.

Originalsprog	Engelsk
Tidsskrift	American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
Vol/bind	298
Udgave nummer	3
Sider (fra-til)	R843-R848
Antal sider	6
ISSN	0363-6119
DOI	https://doi.org/10.1152/ajpregu.00730.2009
Status	Udgivet - mar. 2010

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10.1152/ajpregu.00730.2009

Citationsformater

Low blood flow at onset of moderate intensity exercise does not limit muscle oxygen uptake. / Nyberg, Michael Permin; Mortensen, Stefan Peter; Saltin, Bengt et al.

I: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Bind 298, Nr. 3, 03.2010, s. R843-R848.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "Low blood flow at onset of moderate intensity exercise does not limit muscle oxygen uptake",

abstract = "The effect of low blood flow at onset of moderate-intensity exercise on the rate of rise in muscle oxygen uptake was examined. Seven male subjects performed a 3.5-min one-legged knee-extensor exercise bout (24 ± 1 W, mean ± SD) without (Con) and with (double blockade; DB) arterial infusion of inhibitors of nitric oxide synthase (NG-monomethyl-L-arginine) and cyclooxygenase (indomethacin) to inhibit the synthesis of nitric oxide and prostanoids, respectively. Leg blood flow and leg oxygen delivery throughout exercise was 25-50% lower (P < 0.05) in DB compared with Con. Leg oxygen extraction (arteriovenous O2 difference) was higher (P < 0.05) in DB than in Con (5 s: 127 ± 3 vs. 56 ± 4 ml/l), and leg oxygen uptake was not different between Con and DB during exercise. The difference between leg oxygen delivery and leg oxygen uptake was smaller (P < 0.05) during exercise in DB than in Con (5 s: 59 ± 12 vs. 262 ± 39 ml/min). The present data demonstrate that muscle blood flow and oxygen delivery can be markedly reduced without affecting muscle oxygen uptake in the initial phase of moderate-intensity exercise, suggesting that blood flow does not limit muscle oxygen uptake at the onset of exercise. Additionally, prostanoids and/or nitric oxide appear to play important roles in elevating skeletal muscle blood flow in the initial phase of exercise.",

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AU - Nyberg, Michael Permin

AU - Mortensen, Stefan Peter

AU - Saltin, Bengt

AU - Hellsten, Ylva

AU - Bangsbo, Jens

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N2 - The effect of low blood flow at onset of moderate-intensity exercise on the rate of rise in muscle oxygen uptake was examined. Seven male subjects performed a 3.5-min one-legged knee-extensor exercise bout (24 ± 1 W, mean ± SD) without (Con) and with (double blockade; DB) arterial infusion of inhibitors of nitric oxide synthase (NG-monomethyl-L-arginine) and cyclooxygenase (indomethacin) to inhibit the synthesis of nitric oxide and prostanoids, respectively. Leg blood flow and leg oxygen delivery throughout exercise was 25-50% lower (P < 0.05) in DB compared with Con. Leg oxygen extraction (arteriovenous O2 difference) was higher (P < 0.05) in DB than in Con (5 s: 127 ± 3 vs. 56 ± 4 ml/l), and leg oxygen uptake was not different between Con and DB during exercise. The difference between leg oxygen delivery and leg oxygen uptake was smaller (P < 0.05) during exercise in DB than in Con (5 s: 59 ± 12 vs. 262 ± 39 ml/min). The present data demonstrate that muscle blood flow and oxygen delivery can be markedly reduced without affecting muscle oxygen uptake in the initial phase of moderate-intensity exercise, suggesting that blood flow does not limit muscle oxygen uptake at the onset of exercise. Additionally, prostanoids and/or nitric oxide appear to play important roles in elevating skeletal muscle blood flow in the initial phase of exercise.

AB - The effect of low blood flow at onset of moderate-intensity exercise on the rate of rise in muscle oxygen uptake was examined. Seven male subjects performed a 3.5-min one-legged knee-extensor exercise bout (24 ± 1 W, mean ± SD) without (Con) and with (double blockade; DB) arterial infusion of inhibitors of nitric oxide synthase (NG-monomethyl-L-arginine) and cyclooxygenase (indomethacin) to inhibit the synthesis of nitric oxide and prostanoids, respectively. Leg blood flow and leg oxygen delivery throughout exercise was 25-50% lower (P < 0.05) in DB compared with Con. Leg oxygen extraction (arteriovenous O2 difference) was higher (P < 0.05) in DB than in Con (5 s: 127 ± 3 vs. 56 ± 4 ml/l), and leg oxygen uptake was not different between Con and DB during exercise. The difference between leg oxygen delivery and leg oxygen uptake was smaller (P < 0.05) during exercise in DB than in Con (5 s: 59 ± 12 vs. 262 ± 39 ml/min). The present data demonstrate that muscle blood flow and oxygen delivery can be markedly reduced without affecting muscle oxygen uptake in the initial phase of moderate-intensity exercise, suggesting that blood flow does not limit muscle oxygen uptake at the onset of exercise. Additionally, prostanoids and/or nitric oxide appear to play important roles in elevating skeletal muscle blood flow in the initial phase of exercise.

U2 - 10.1152/ajpregu.00730.2009

DO - 10.1152/ajpregu.00730.2009

M3 - Journal article

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JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology

JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology

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ER -

Low blood flow at onset of moderate intensity exercise does not limit muscle oxygen uptake

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