Low birth weight, adult BMI and inflammation in middle age

Jolene Lee Masters Pedersen; Naja Hulvej Rod; Kirsten Avlund; Esben Budtz-Jørgensen; Erik Lykke Mortensen; Thorkild I.A. Sørensen; Rikke Lund

doi:10.1093/geront/gnt151

Low birth weight, adult BMI and inflammation in middle age

Jolene Lee Masters Pedersen, Naja Hulvej Rod, Kirsten Avlund, Esben Budtz-Jørgensen, Erik Lykke Mortensen, Thorkild I.A. Sørensen, Rikke Lund

Abstract

This study examines the association between birthweight and adult
BMI with inflammation in middle age measured by interleukin 6 (IL-
6), interleukin 10 (IL-10), interleukin 18 (IL-18), high sensitivity Creactive
protein (hsCRP) and tumor necrosis factor alpha (tnf-α). The
study is based on participants with continued participation in the Copenhagen
Perinatal cohort and Copenhagen Aging and Midlife Biobank
clinical examination (n=1,719). Birthweight was negatively associated
with hsCRP and IL-18.No association was identified with tnf-α, IL-6
and IL-10. Adult BMI was positively and significantly associated with
all measures of inflammation besides IL-10. Finally, participants in both
the lowest tertile of birthweight and highest tertile of adult BMI had
the highest levels of all inflammatory markers. Low birthweight and
high adult BMI are risk factors for inflammation in middle age. While
the prenatal period may be sensitive for development of inflammation
it appears that modification by adult BMI occurred in this sample.

Originalsprog	Engelsk
Tidsskrift	Gerontologist
Vol/bind	53
Udgave nummer	suppl. 1
Sider (fra-til)	380
ISSN	0016-9013
DOI	https://doi.org/10.1093/geront/gnt151
Status	Udgivet - 2013

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10.1093/geront/gnt151

Citationsformater

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title = "Low birth weight, adult BMI and inflammation in middle age",

abstract = "This study examines the association between birthweight and adultBMI with inflammation in middle age measured by interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 18 (IL-18), high sensitivity Creactiveprotein (hsCRP) and tumor necrosis factor alpha (tnf-α). Thestudy is based on participants with continued participation in the CopenhagenPerinatal cohort and Copenhagen Aging and Midlife Biobankclinical examination (n=1,719). Birthweight was negatively associatedwith hsCRP and IL-18.No association was identified with tnf-α, IL-6and IL-10. Adult BMI was positively and significantly associated withall measures of inflammation besides IL-10. Finally, participants in boththe lowest tertile of birthweight and highest tertile of adult BMI hadthe highest levels of all inflammatory markers. Low birthweight andhigh adult BMI are risk factors for inflammation in middle age. Whilethe prenatal period may be sensitive for development of inflammationit appears that modification by adult BMI occurred in this sample.",

author = "Pedersen, {Jolene Lee Masters} and Rod, {Naja Hulvej} and Kirsten Avlund and Esben Budtz-J{\o}rgensen and Mortensen, {Erik Lykke} and S{\o}rensen, {Thorkild I.A.} and Rikke Lund",

year = "2013",

doi = "10.1093/geront/gnt151",

language = "English",

volume = "53",

pages = "380",

journal = "The Gerontologist",

issn = "0016-9013",

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T1 - Low birth weight, adult BMI and inflammation in middle age

AU - Pedersen, Jolene Lee Masters

AU - Rod, Naja Hulvej

AU - Avlund, Kirsten

AU - Budtz-Jørgensen, Esben

AU - Mortensen, Erik Lykke

AU - Sørensen, Thorkild I.A.

AU - Lund, Rikke

PY - 2013

Y1 - 2013

N2 - This study examines the association between birthweight and adultBMI with inflammation in middle age measured by interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 18 (IL-18), high sensitivity Creactiveprotein (hsCRP) and tumor necrosis factor alpha (tnf-α). Thestudy is based on participants with continued participation in the CopenhagenPerinatal cohort and Copenhagen Aging and Midlife Biobankclinical examination (n=1,719). Birthweight was negatively associatedwith hsCRP and IL-18.No association was identified with tnf-α, IL-6and IL-10. Adult BMI was positively and significantly associated withall measures of inflammation besides IL-10. Finally, participants in boththe lowest tertile of birthweight and highest tertile of adult BMI hadthe highest levels of all inflammatory markers. Low birthweight andhigh adult BMI are risk factors for inflammation in middle age. Whilethe prenatal period may be sensitive for development of inflammationit appears that modification by adult BMI occurred in this sample.

AB - This study examines the association between birthweight and adultBMI with inflammation in middle age measured by interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 18 (IL-18), high sensitivity Creactiveprotein (hsCRP) and tumor necrosis factor alpha (tnf-α). Thestudy is based on participants with continued participation in the CopenhagenPerinatal cohort and Copenhagen Aging and Midlife Biobankclinical examination (n=1,719). Birthweight was negatively associatedwith hsCRP and IL-18.No association was identified with tnf-α, IL-6and IL-10. Adult BMI was positively and significantly associated withall measures of inflammation besides IL-10. Finally, participants in boththe lowest tertile of birthweight and highest tertile of adult BMI hadthe highest levels of all inflammatory markers. Low birthweight andhigh adult BMI are risk factors for inflammation in middle age. Whilethe prenatal period may be sensitive for development of inflammationit appears that modification by adult BMI occurred in this sample.

U2 - 10.1093/geront/gnt151

DO - 10.1093/geront/gnt151

M3 - Conference article

SN - 0016-9013

VL - 53

SP - 380

JO - The Gerontologist

JF - The Gerontologist

IS - suppl. 1

ER -

Low birth weight, adult BMI and inflammation in middle age

Abstract

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