Longitudinal shortening of sub-epicardial myocytes in severe ischaemic cardiomyopathy: insights from gadolinium contrast cardiac magnetic resonance imaging

Jenny Bjerre; Kasper Kyhl; Finn Gustafsson; Henning Kelbaek; Thomas Engstrøm; Peter Skov Olsen; Philip Hasbak; Niels Vejlstrup; Per Lav Madsen

doi:10.1002/ehf2.12187

Longitudinal shortening of sub-epicardial myocytes in severe ischaemic cardiomyopathy: insights from gadolinium contrast cardiac magnetic resonance imaging

Jenny Bjerre, Kasper Kyhl, Finn Gustafsson, Henning Kelbaek, Thomas Engstrøm, Peter Skov Olsen, Philip Hasbak, Niels Vejlstrup, Per Lav Madsen

Institut for Klinisk Medicin

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Abstract

We present two patients with three-vessel disease and severely depressed left ventricular (LV) systolic function where viability analysis by cardiac magnetic resonance imaging demonstrated areas of near-transmural sub-endocardial fibrosis and hence little chance of regaining systolic function as judged by conventional analysis from radial function. Despite the pessimistic cardiac magnetic resonance imaging analysis, however, the patients underwent full revascularization and regained impressive increases in LV systolic function mainly based on improved longitudinal systolic segment function. The cases highlight that sub-epicardial, longitudinally oriented myocytes can contribute to overall LV systolic function and suggest taking their 'piston-function' into consideration when analysing viability.

Originalsprog	Engelsk
Tidsskrift	E S C Heart Failure
Vol/bind	4
Udgave nummer	4
Sider (fra-til)	670-674
Antal sider	5
ISSN	2055-5822
DOI	https://doi.org/10.1002/ehf2.12187
Status	Udgivet - nov. 2017

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10.1002/ehf2.12187Licens: CC BY-NC-ND

Bjerre_et_al-2017-ESC_Heart_FailureForlagets udgivne version, 753 KBLicens: CC BY-NC-ND

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abstract = "We present two patients with three-vessel disease and severely depressed left ventricular (LV) systolic function where viability analysis by cardiac magnetic resonance imaging demonstrated areas of near-transmural sub-endocardial fibrosis and hence little chance of regaining systolic function as judged by conventional analysis from radial function. Despite the pessimistic cardiac magnetic resonance imaging analysis, however, the patients underwent full revascularization and regained impressive increases in LV systolic function mainly based on improved longitudinal systolic segment function. The cases highlight that sub-epicardial, longitudinally oriented myocytes can contribute to overall LV systolic function and suggest taking their 'piston-function' into consideration when analysing viability.",

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T1 - Longitudinal shortening of sub-epicardial myocytes in severe ischaemic cardiomyopathy

T2 - insights from gadolinium contrast cardiac magnetic resonance imaging

AU - Bjerre, Jenny

AU - Kyhl, Kasper

AU - Gustafsson, Finn

AU - Kelbaek, Henning

AU - Engstrøm, Thomas

AU - Olsen, Peter Skov

AU - Hasbak, Philip

AU - Vejlstrup, Niels

AU - Madsen, Per Lav

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N2 - We present two patients with three-vessel disease and severely depressed left ventricular (LV) systolic function where viability analysis by cardiac magnetic resonance imaging demonstrated areas of near-transmural sub-endocardial fibrosis and hence little chance of regaining systolic function as judged by conventional analysis from radial function. Despite the pessimistic cardiac magnetic resonance imaging analysis, however, the patients underwent full revascularization and regained impressive increases in LV systolic function mainly based on improved longitudinal systolic segment function. The cases highlight that sub-epicardial, longitudinally oriented myocytes can contribute to overall LV systolic function and suggest taking their 'piston-function' into consideration when analysing viability.

AB - We present two patients with three-vessel disease and severely depressed left ventricular (LV) systolic function where viability analysis by cardiac magnetic resonance imaging demonstrated areas of near-transmural sub-endocardial fibrosis and hence little chance of regaining systolic function as judged by conventional analysis from radial function. Despite the pessimistic cardiac magnetic resonance imaging analysis, however, the patients underwent full revascularization and regained impressive increases in LV systolic function mainly based on improved longitudinal systolic segment function. The cases highlight that sub-epicardial, longitudinally oriented myocytes can contribute to overall LV systolic function and suggest taking their 'piston-function' into consideration when analysing viability.

KW - Case Reports

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DO - 10.1002/ehf2.12187

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JO - E S C Heart Failure

JF - E S C Heart Failure

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Longitudinal shortening of sub-epicardial myocytes in severe ischaemic cardiomyopathy: insights from gadolinium contrast cardiac magnetic resonance imaging

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