Long-term Risk of Cancer Following Ileal Pouch-anal Anastomosis for Ulcerative Colitis

Anders Mark-Christensen; Rune Erichsen; Søren Brandsborg; Jacob Rosenberg; Niels Qvist; Ole Thorlacius-Ussing; Jens Hillingsø; Jørn Helmut Pachler; Erica Gould Christiansen; Søren Laurberg

doi:10.1093/ecco-jcc/jjx112

Long-term Risk of Cancer Following Ileal Pouch-anal Anastomosis for Ulcerative Colitis

Anders Mark-Christensen, Rune Erichsen, Søren Brandsborg, Jacob Rosenberg, Niels Qvist, Ole Thorlacius-Ussing, Jens Hillingsø, Jørn Helmut Pachler, Erica Gould Christiansen, Søren Laurberg

Institut for Klinisk Medicin

7 Citationer (Scopus)

Abstract

Background: The overall risk of cancer following ileal pouch-anal anastomosis [IPAA] is unknown, and pouch cancer surveillance is controversial. We evaluated long-term risk of cancer in a national cohort of patients with ulcerative colitis and IPAA, with emphasis on pouch cancer.

Methods: Data on incident cancers were extracted from the national Danish Cancer Registry. Incidence rates for all site-specific cancers were compared between patients with IPAA and a gender- and age-matched comparison cohort from the background population to obtain incidence rate ratios [IRRs].

Results: A total of 1723 patients with IPAA, operated for ulcerative colitis in the period 1980-2010, were matched to 8615 individuals from the background population. During a median follow-up of 12.9 years (interquartile range [IQR] 7.7-19.6 years), two pouch cancers [0.12%] were found after 16 and 27 years, respectively. In the population comparison cohort, 38 intestinal cancers [0.45%] were found, of which 35 were colorectal. The risk of hepatobiliary cancer was higher for patients with IPAA {IRR = 13.0 (95% confidence interval [CI]: 3.1-76.1)}, and half of the affected patients had coexisting primary sclerosing cholangitis. The risk of cancer overall following IPAA was identical to that of the comparison cohort: IRR = 1.05 [0.84-1.31].

Conclusions: Pouch cancer following IPAA is very rare, questioning the need for general, rather than selective, surveillance. The overall cancer risk is comparable to that of the background population, and the increased risk of hepatobiliary cancer is likely an effect of coexisting liver disease and not causally related to IPAA.

Originalsprog	Engelsk
Tidsskrift	Journal of Crohn's and Colitis
Vol/bind	12
Udgave nummer	1
Sider (fra-til)	57-62
ISSN	1873-9946
DOI	https://doi.org/10.1093/ecco-jcc/jjx112
Status	Udgivet - 1 jan. 2018

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title = "Long-term Risk of Cancer Following Ileal Pouch-anal Anastomosis for Ulcerative Colitis",

abstract = "Background: The overall risk of cancer following ileal pouch-anal anastomosis [IPAA] is unknown, and pouch cancer surveillance is controversial. We evaluated long-term risk of cancer in a national cohort of patients with ulcerative colitis and IPAA, with emphasis on pouch cancer.Methods: Data on incident cancers were extracted from the national Danish Cancer Registry. Incidence rates for all site-specific cancers were compared between patients with IPAA and a gender- and age-matched comparison cohort from the background population to obtain incidence rate ratios [IRRs].Results: A total of 1723 patients with IPAA, operated for ulcerative colitis in the period 1980-2010, were matched to 8615 individuals from the background population. During a median follow-up of 12.9 years (interquartile range [IQR] 7.7-19.6 years), two pouch cancers [0.12%] were found after 16 and 27 years, respectively. In the population comparison cohort, 38 intestinal cancers [0.45%] were found, of which 35 were colorectal. The risk of hepatobiliary cancer was higher for patients with IPAA {IRR = 13.0 (95% confidence interval [CI]: 3.1-76.1)}, and half of the affected patients had coexisting primary sclerosing cholangitis. The risk of cancer overall following IPAA was identical to that of the comparison cohort: IRR = 1.05 [0.84-1.31].Conclusions: Pouch cancer following IPAA is very rare, questioning the need for general, rather than selective, surveillance. The overall cancer risk is comparable to that of the background population, and the increased risk of hepatobiliary cancer is likely an effect of coexisting liver disease and not causally related to IPAA.",

keywords = "Adult, Biliary Tract Neoplasms/epidemiology, Case-Control Studies, Cholangitis, Sclerosing/complications, Colitis, Ulcerative/complications, Colonic Pouches/pathology, Colorectal Neoplasms/epidemiology, Denmark/epidemiology, Female, Follow-Up Studies, Humans, Incidence, Liver Neoplasms/epidemiology, Male, Proctocolectomy, Restorative, Registries, Time Factors, Young Adult",

author = "Anders Mark-Christensen and Rune Erichsen and S{\o}ren Brandsborg and Jacob Rosenberg and Niels Qvist and Ole Thorlacius-Ussing and Jens Hillings{\o} and Pachler, {J{\o}rn Helmut} and Christiansen, {Erica Gould} and S{\o}ren Laurberg",

note = "Copyright {\textcopyright} 2017 European Crohn{\textquoteright}s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: [email protected]",

year = "2018",

month = jan,

day = "1",

doi = "10.1093/ecco-jcc/jjx112",

language = "English",

volume = "12",

pages = "57--62",

journal = "Journal of Crohn's and Colitis",

issn = "1873-9946",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - Long-term Risk of Cancer Following Ileal Pouch-anal Anastomosis for Ulcerative Colitis

AU - Mark-Christensen, Anders

AU - Erichsen, Rune

AU - Brandsborg, Søren

AU - Rosenberg, Jacob

AU - Qvist, Niels

AU - Thorlacius-Ussing, Ole

AU - Hillingsø, Jens

AU - Pachler, Jørn Helmut

AU - Christiansen, Erica Gould

AU - Laurberg, Søren

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: The overall risk of cancer following ileal pouch-anal anastomosis [IPAA] is unknown, and pouch cancer surveillance is controversial. We evaluated long-term risk of cancer in a national cohort of patients with ulcerative colitis and IPAA, with emphasis on pouch cancer.Methods: Data on incident cancers were extracted from the national Danish Cancer Registry. Incidence rates for all site-specific cancers were compared between patients with IPAA and a gender- and age-matched comparison cohort from the background population to obtain incidence rate ratios [IRRs].Results: A total of 1723 patients with IPAA, operated for ulcerative colitis in the period 1980-2010, were matched to 8615 individuals from the background population. During a median follow-up of 12.9 years (interquartile range [IQR] 7.7-19.6 years), two pouch cancers [0.12%] were found after 16 and 27 years, respectively. In the population comparison cohort, 38 intestinal cancers [0.45%] were found, of which 35 were colorectal. The risk of hepatobiliary cancer was higher for patients with IPAA {IRR = 13.0 (95% confidence interval [CI]: 3.1-76.1)}, and half of the affected patients had coexisting primary sclerosing cholangitis. The risk of cancer overall following IPAA was identical to that of the comparison cohort: IRR = 1.05 [0.84-1.31].Conclusions: Pouch cancer following IPAA is very rare, questioning the need for general, rather than selective, surveillance. The overall cancer risk is comparable to that of the background population, and the increased risk of hepatobiliary cancer is likely an effect of coexisting liver disease and not causally related to IPAA.

AB - Background: The overall risk of cancer following ileal pouch-anal anastomosis [IPAA] is unknown, and pouch cancer surveillance is controversial. We evaluated long-term risk of cancer in a national cohort of patients with ulcerative colitis and IPAA, with emphasis on pouch cancer.Methods: Data on incident cancers were extracted from the national Danish Cancer Registry. Incidence rates for all site-specific cancers were compared between patients with IPAA and a gender- and age-matched comparison cohort from the background population to obtain incidence rate ratios [IRRs].Results: A total of 1723 patients with IPAA, operated for ulcerative colitis in the period 1980-2010, were matched to 8615 individuals from the background population. During a median follow-up of 12.9 years (interquartile range [IQR] 7.7-19.6 years), two pouch cancers [0.12%] were found after 16 and 27 years, respectively. In the population comparison cohort, 38 intestinal cancers [0.45%] were found, of which 35 were colorectal. The risk of hepatobiliary cancer was higher for patients with IPAA {IRR = 13.0 (95% confidence interval [CI]: 3.1-76.1)}, and half of the affected patients had coexisting primary sclerosing cholangitis. The risk of cancer overall following IPAA was identical to that of the comparison cohort: IRR = 1.05 [0.84-1.31].Conclusions: Pouch cancer following IPAA is very rare, questioning the need for general, rather than selective, surveillance. The overall cancer risk is comparable to that of the background population, and the increased risk of hepatobiliary cancer is likely an effect of coexisting liver disease and not causally related to IPAA.

KW - Adult

KW - Biliary Tract Neoplasms/epidemiology

KW - Case-Control Studies

KW - Cholangitis, Sclerosing/complications

KW - Colitis, Ulcerative/complications

KW - Colonic Pouches/pathology

KW - Colorectal Neoplasms/epidemiology

KW - Denmark/epidemiology

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Liver Neoplasms/epidemiology

KW - Male

KW - Proctocolectomy, Restorative

KW - Registries

KW - Time Factors

KW - Young Adult

U2 - 10.1093/ecco-jcc/jjx112

DO - 10.1093/ecco-jcc/jjx112

M3 - Journal article

C2 - 28981638

SN - 1873-9946

VL - 12

SP - 57

EP - 62

JO - Journal of Crohn's and Colitis

JF - Journal of Crohn's and Colitis

IS - 1

ER -

Long-term Risk of Cancer Following Ileal Pouch-anal Anastomosis for Ulcerative Colitis

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