Long-term Exposure to Particulate Matter Constituents and the Incidence of Coronary Events in 11 European Cohorts

Kathrin Wolf; Massimo Stafoggia; Giulia Cesaroni; Zorana Jovanovic Andersen; Rob Beelen; Claudia Galassi; Frauke Hennig; Enrica Migliore; Johanna Penell; Fulvio Ricceri; Mette Sørensen; Anu W Turunen; Regina Hampel; Barbara Hoffmann; Hagen Kälsch; Tiina Laatikainen; Göran Pershagen; Ole Raaschou-Nielsen; Carlotta Sacerdote; Paolo Vineis; Chiara Badaloni; Josef Cyrys; Kees de Hoogh; Kirsten T Eriksen; Aleksandra Jedynska; Menno Keuken; Ingeborg Kooter; Timo Lanki; Andrea Ranzi; Dorothea Sugiri; Ming-Yi Tsai; Meng Wang; Gerard Hoek; Bert Brunekreef; Annette Peters; Francesco Forastiere

doi:10.1097/EDE.0000000000000300

Long-term Exposure to Particulate Matter Constituents and the Incidence of Coronary Events in 11 European Cohorts

Kathrin Wolf, Massimo Stafoggia, Giulia Cesaroni, Zorana Jovanovic Andersen, Rob Beelen, Claudia Galassi, Frauke Hennig, Enrica Migliore, Johanna Penell, Fulvio Ricceri, Mette Sørensen, Anu W Turunen, Regina Hampel, Barbara Hoffmann, Hagen Kälsch, Tiina Laatikainen, Göran Pershagen, Ole Raaschou-Nielsen, Carlotta Sacerdote, Paolo VineisChiara Badaloni, Josef Cyrys, Kees de Hoogh, Kirsten T Eriksen, Aleksandra Jedynska, Menno Keuken, Ingeborg Kooter, Timo Lanki, Andrea Ranzi, Dorothea Sugiri, Ming-Yi Tsai, Meng Wang, Gerard Hoek, Bert Brunekreef, Annette Peters, Francesco Forastiere

Center for Epidemiologi og Screening

37 Citationer (Scopus)

Abstract

BACKGROUND: Long-term exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity and mortality but little is known about the role of the chemical composition of PM. This study examined the association of residential long-term exposure to PM components with incident coronary events.

METHODS: Eleven cohorts from Finland, Sweden, Denmark, Germany, and Italy participated in this analysis. 5,157 incident coronary events were identified within 100,166 persons followed on average for 11.5 years. Long-term residential concentrations of PM < 10 μm (PM₁₀), PM < 2.5 μm (PM_2.5), and a priori selected constituents (copper, iron, nickel, potassium, silicon, sulfur, vanadium, and zinc) were estimated with land-use regression models. We used Cox proportional hazard models adjusted for a common set of confounders to estimate cohort-specific component effects with and without including PM mass, and random effects meta-analyses to pool cohort-specific results.

RESULTS: A 100 ng/m³ increase in PM₁₀ K and a 50 ng/m³ increase in PM_2.5 K were associated with a 6% (hazard ratio and 95% confidence interval: 1.06 [1.01, 1.12]) and 18% (1.18 [1.06, 1.32]) increase in coronary events. Estimates for PM₁₀ Si and PM_2.5 Fe were also elevated. All other PM constituents indicated a positive association with coronary events. When additionally adjusting for PM mass, the estimates decreased except for K.

CONCLUSIONS: This multicenter study of 11 European cohorts pointed to an association between long-term exposure to PM constituents and coronary events, especially for indicators of road dust.

Originalsprog	Engelsk
Tidsskrift	Epidemiology (Cambridge, Mass.)
Vol/bind	26
Udgave nummer	4
Sider (fra-til)	565–574
Antal sider	10
ISSN	1044-3983
DOI	https://doi.org/10.1097/EDE.0000000000000300
Status	Udgivet - 4 jul. 2015

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Wolf, K., Stafoggia, M., Cesaroni, G., Andersen, Z. J., Beelen, R., Galassi, C., Hennig, F., Migliore, E., Penell, J., Ricceri, F., Sørensen, M., Turunen, A. W., Hampel, R., Hoffmann, B., Kälsch, H., Laatikainen, T., Pershagen, G., Raaschou-Nielsen, O., Sacerdote, C., ... Forastiere, F. (2015). Long-term Exposure to Particulate Matter Constituents and the Incidence of Coronary Events in 11 European Cohorts. Epidemiology (Cambridge, Mass.), 26(4), 565–574. https://doi.org/10.1097/EDE.0000000000000300

Wolf, K, Stafoggia, M, Cesaroni, G, Andersen, ZJ, Beelen, R, Galassi, C, Hennig, F, Migliore, E, Penell, J, Ricceri, F, Sørensen, M, Turunen, AW, Hampel, R, Hoffmann, B, Kälsch, H, Laatikainen, T, Pershagen, G, Raaschou-Nielsen, O, Sacerdote, C, Vineis, P, Badaloni, C, Cyrys, J, de Hoogh, K, Eriksen, KT, Jedynska, A, Keuken, M, Kooter, I, Lanki, T, Ranzi, A, Sugiri, D, Tsai, M-Y, Wang, M, Hoek, G, Brunekreef, B, Peters, A & Forastiere, F 2015, 'Long-term Exposure to Particulate Matter Constituents and the Incidence of Coronary Events in 11 European Cohorts', Epidemiology (Cambridge, Mass.), bind 26, nr. 4, s. 565–574. https://doi.org/10.1097/EDE.0000000000000300

@article{183eeb594b9c4c8693861dd4f3a7d6ee,

title = "Long-term Exposure to Particulate Matter Constituents and the Incidence of Coronary Events in 11 European Cohorts",

abstract = "BACKGROUND: Long-term exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity and mortality but little is known about the role of the chemical composition of PM. This study examined the association of residential long-term exposure to PM components with incident coronary events.METHODS: Eleven cohorts from Finland, Sweden, Denmark, Germany, and Italy participated in this analysis. 5,157 incident coronary events were identified within 100,166 persons followed on average for 11.5 years. Long-term residential concentrations of PM < 10 μm (PM10), PM < 2.5 μm (PM2.5), and a priori selected constituents (copper, iron, nickel, potassium, silicon, sulfur, vanadium, and zinc) were estimated with land-use regression models. We used Cox proportional hazard models adjusted for a common set of confounders to estimate cohort-specific component effects with and without including PM mass, and random effects meta-analyses to pool cohort-specific results.RESULTS: A 100 ng/m³ increase in PM10 K and a 50 ng/m³ increase in PM2.5 K were associated with a 6% (hazard ratio and 95% confidence interval: 1.06 [1.01, 1.12]) and 18% (1.18 [1.06, 1.32]) increase in coronary events. Estimates for PM10 Si and PM2.5 Fe were also elevated. All other PM constituents indicated a positive association with coronary events. When additionally adjusting for PM mass, the estimates decreased except for K.CONCLUSIONS: This multicenter study of 11 European cohorts pointed to an association between long-term exposure to PM constituents and coronary events, especially for indicators of road dust.",

author = "Kathrin Wolf and Massimo Stafoggia and Giulia Cesaroni and Andersen, {Zorana Jovanovic} and Rob Beelen and Claudia Galassi and Frauke Hennig and Enrica Migliore and Johanna Penell and Fulvio Ricceri and Mette S{\o}rensen and Turunen, {Anu W} and Regina Hampel and Barbara Hoffmann and Hagen K{\"a}lsch and Tiina Laatikainen and G{\"o}ran Pershagen and Ole Raaschou-Nielsen and Carlotta Sacerdote and Paolo Vineis and Chiara Badaloni and Josef Cyrys and {de Hoogh}, Kees and Eriksen, {Kirsten T} and Aleksandra Jedynska and Menno Keuken and Ingeborg Kooter and Timo Lanki and Andrea Ranzi and Dorothea Sugiri and Ming-Yi Tsai and Meng Wang and Gerard Hoek and Bert Brunekreef and Annette Peters and Francesco Forastiere",

year = "2015",

month = jul,

day = "4",

doi = "10.1097/EDE.0000000000000300",

language = "English",

volume = "26",

pages = "565–574",

journal = "Epidemiology",

issn = "1044-3983",

publisher = "Lippincott Williams & Wilkins",

number = "4",

}

TY - JOUR

T1 - Long-term Exposure to Particulate Matter Constituents and the Incidence of Coronary Events in 11 European Cohorts

AU - Wolf, Kathrin

AU - Stafoggia, Massimo

AU - Cesaroni, Giulia

AU - Andersen, Zorana Jovanovic

AU - Beelen, Rob

AU - Galassi, Claudia

AU - Hennig, Frauke

AU - Migliore, Enrica

AU - Penell, Johanna

AU - Ricceri, Fulvio

AU - Sørensen, Mette

AU - Turunen, Anu W

AU - Hampel, Regina

AU - Hoffmann, Barbara

AU - Kälsch, Hagen

AU - Laatikainen, Tiina

AU - Pershagen, Göran

AU - Raaschou-Nielsen, Ole

AU - Sacerdote, Carlotta

AU - Vineis, Paolo

AU - Badaloni, Chiara

AU - Cyrys, Josef

AU - de Hoogh, Kees

AU - Eriksen, Kirsten T

AU - Jedynska, Aleksandra

AU - Keuken, Menno

AU - Kooter, Ingeborg

AU - Lanki, Timo

AU - Ranzi, Andrea

AU - Sugiri, Dorothea

AU - Tsai, Ming-Yi

AU - Wang, Meng

AU - Hoek, Gerard

AU - Brunekreef, Bert

AU - Peters, Annette

AU - Forastiere, Francesco

PY - 2015/7/4

Y1 - 2015/7/4

N2 - BACKGROUND: Long-term exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity and mortality but little is known about the role of the chemical composition of PM. This study examined the association of residential long-term exposure to PM components with incident coronary events.METHODS: Eleven cohorts from Finland, Sweden, Denmark, Germany, and Italy participated in this analysis. 5,157 incident coronary events were identified within 100,166 persons followed on average for 11.5 years. Long-term residential concentrations of PM < 10 μm (PM10), PM < 2.5 μm (PM2.5), and a priori selected constituents (copper, iron, nickel, potassium, silicon, sulfur, vanadium, and zinc) were estimated with land-use regression models. We used Cox proportional hazard models adjusted for a common set of confounders to estimate cohort-specific component effects with and without including PM mass, and random effects meta-analyses to pool cohort-specific results.RESULTS: A 100 ng/m³ increase in PM10 K and a 50 ng/m³ increase in PM2.5 K were associated with a 6% (hazard ratio and 95% confidence interval: 1.06 [1.01, 1.12]) and 18% (1.18 [1.06, 1.32]) increase in coronary events. Estimates for PM10 Si and PM2.5 Fe were also elevated. All other PM constituents indicated a positive association with coronary events. When additionally adjusting for PM mass, the estimates decreased except for K.CONCLUSIONS: This multicenter study of 11 European cohorts pointed to an association between long-term exposure to PM constituents and coronary events, especially for indicators of road dust.

AB - BACKGROUND: Long-term exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity and mortality but little is known about the role of the chemical composition of PM. This study examined the association of residential long-term exposure to PM components with incident coronary events.METHODS: Eleven cohorts from Finland, Sweden, Denmark, Germany, and Italy participated in this analysis. 5,157 incident coronary events were identified within 100,166 persons followed on average for 11.5 years. Long-term residential concentrations of PM < 10 μm (PM10), PM < 2.5 μm (PM2.5), and a priori selected constituents (copper, iron, nickel, potassium, silicon, sulfur, vanadium, and zinc) were estimated with land-use regression models. We used Cox proportional hazard models adjusted for a common set of confounders to estimate cohort-specific component effects with and without including PM mass, and random effects meta-analyses to pool cohort-specific results.RESULTS: A 100 ng/m³ increase in PM10 K and a 50 ng/m³ increase in PM2.5 K were associated with a 6% (hazard ratio and 95% confidence interval: 1.06 [1.01, 1.12]) and 18% (1.18 [1.06, 1.32]) increase in coronary events. Estimates for PM10 Si and PM2.5 Fe were also elevated. All other PM constituents indicated a positive association with coronary events. When additionally adjusting for PM mass, the estimates decreased except for K.CONCLUSIONS: This multicenter study of 11 European cohorts pointed to an association between long-term exposure to PM constituents and coronary events, especially for indicators of road dust.

U2 - 10.1097/EDE.0000000000000300

DO - 10.1097/EDE.0000000000000300

M3 - Journal article

C2 - 25978793

SN - 1044-3983

VL - 26

SP - 565

EP - 574

JO - Epidemiology

JF - Epidemiology

IS - 4

ER -

Long-term Exposure to Particulate Matter Constituents and the Incidence of Coronary Events in 11 European Cohorts

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