TY - JOUR
T1 - Long-term effects of weight reduction on the severity of psoriasis in a cohort derived from a randomized trial
T2 - A prospective observational follow-up study
AU - Jensen, Peter
AU - Christensen, Robin
AU - Zachariae, Claus
AU - Geiker, Nina Rica Wium
AU - Schaadt, Bente K
AU - Stender, Steen
AU - Hansen, Peter R
AU - Astrup, Arne
AU - Skov, Lone
N1 - CURIS 2016 NEXS 171
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Weight reduction may reduce the severity of psoriasis, but little is known about the long-term effects. Objective: We aimed to investigate long-term effects of weight reduction in psoriasis. Design: We previously conducted a randomized trial (n = 60) involving patients with psoriasis who were allocated to a control group or a low-energy diet (LED) group. Here we followed the participants for an additional 48-wk period. In total, 56 patients with psoriasis [mean ± SD body mass index (in kg/m2): 34.4 ± 5.3] underwent a 64-wk weight-loss program consisting of an initial 16-wk randomized phase with an LED for 8 wk and 8 wk of normal food intake combined with 2 LED products/d, followed by a 48-wk period of weight maintenance with the latter diet. After the randomization phase, the control group received the same 8 + 8-wk LED intervention, and all patients were then followed for 48 wk while on the weight-loss maintenance diet. The main outcome was the Psoriasis Area and Severity Index (PASI), and secondary outcome was the Dermatology Life Quality Index (DLQI). Results: For the present study, 56 patients were eligible, 38 agreed to participate, and 32 completed. After the 16-wk LED-only period, the mean weight loss was-15.0 kg (95% CI:-16.6,-13.4 kg), and PASI and DLQI were reduced by-2.3 (95% CI:-3.1,-1.5) and-2.3 (95% CI:-3.2,-1.4), respectively. At week 64, the mean weight loss compared with baseline was-10.1 kg (95% CI:-12.0,-8.1 kg), and PASI and DLQI were maintained at-2.9 (95% CI:-3.9,-1.9) and-1.9 (95% CI:-3.0,-0.9), respectively. Conclusion: Long-term weight loss in patients with psoriasis has long-lasting positive effects on the severity of psoriasis.
AB - Weight reduction may reduce the severity of psoriasis, but little is known about the long-term effects. Objective: We aimed to investigate long-term effects of weight reduction in psoriasis. Design: We previously conducted a randomized trial (n = 60) involving patients with psoriasis who were allocated to a control group or a low-energy diet (LED) group. Here we followed the participants for an additional 48-wk period. In total, 56 patients with psoriasis [mean ± SD body mass index (in kg/m2): 34.4 ± 5.3] underwent a 64-wk weight-loss program consisting of an initial 16-wk randomized phase with an LED for 8 wk and 8 wk of normal food intake combined with 2 LED products/d, followed by a 48-wk period of weight maintenance with the latter diet. After the randomization phase, the control group received the same 8 + 8-wk LED intervention, and all patients were then followed for 48 wk while on the weight-loss maintenance diet. The main outcome was the Psoriasis Area and Severity Index (PASI), and secondary outcome was the Dermatology Life Quality Index (DLQI). Results: For the present study, 56 patients were eligible, 38 agreed to participate, and 32 completed. After the 16-wk LED-only period, the mean weight loss was-15.0 kg (95% CI:-16.6,-13.4 kg), and PASI and DLQI were reduced by-2.3 (95% CI:-3.1,-1.5) and-2.3 (95% CI:-3.2,-1.4), respectively. At week 64, the mean weight loss compared with baseline was-10.1 kg (95% CI:-12.0,-8.1 kg), and PASI and DLQI were maintained at-2.9 (95% CI:-3.9,-1.9) and-1.9 (95% CI:-3.0,-0.9), respectively. Conclusion: Long-term weight loss in patients with psoriasis has long-lasting positive effects on the severity of psoriasis.
U2 - 10.3945/ajcn.115.125849
DO - 10.3945/ajcn.115.125849
M3 - Journal article
C2 - 27334236
SN - 0002-9165
VL - 104
SP - 259
EP - 265
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 2
ER -