Long-range ordered vorticity patterns in living tissue induced by cell division

Ninna Struck Rossen; Jens Magelund Tarp; Joachim Mathiesen; Mogens Høgh Jensen; Lene Broeng Oddershede

doi:10.1038/ncomms6720

Long-range ordered vorticity patterns in living tissue induced by cell division

Ninna Struck Rossen, Jens Magelund Tarp, Joachim Mathiesen, Mogens Høgh Jensen, Lene Broeng Oddershede

Biokompleksitet

32 Citationer (Scopus)

Abstract

In healthy blood vessels with a laminar blood flow, the endothelial cell division rate is low, only sufficient to replace apoptotic cells. The division rate significantly increases during embryonic development and under halted or turbulent flow. Cells in barrier tissue are connected and their motility is highly correlated. Here we investigate the long-range dynamics induced by cell division in an endothelial monolayer under non-flow conditions, mimicking the conditions during vessel formation or around blood clots. Cell divisions induce long-range, well-ordered vortex patterns extending several cell diameters away from the division site, in spite of the system's low Reynolds number. Our experimental results are reproduced by a hydrodynamic continuum model simulating division as a local pressure increase corresponding to a local tension decrease. Such long-range physical communication may be crucial for embryonic development and for healing tissue, for instance around blood clots.

Originalsprog	Engelsk
Artikelnummer	5720
Tidsskrift	Nature Communications
Vol/bind	5
ISSN	2041-1723
DOI	https://doi.org/10.1038/ncomms6720
Status	Udgivet - 8 dec. 2014

Adgang til dokumentet

10.1038/ncomms6720

Citationsformater

@article{f300b7be8c3e47fdba465f4e9028bef9,

title = "Long-range ordered vorticity patterns in living tissue induced by cell division",

abstract = "In healthy blood vessels with a laminar blood flow, the endothelial cell division rate is low, only sufficient to replace apoptotic cells. The division rate significantly increases during embryonic development and under halted or turbulent flow. Cells in barrier tissue are connected and their motility is highly correlated. Here we investigate the long-range dynamics induced by cell division in an endothelial monolayer under non-flow conditions, mimicking the conditions during vessel formation or around blood clots. Cell divisions induce long-range, well-ordered vortex patterns extending several cell diameters away from the division site, in spite of the system's low Reynolds number. Our experimental results are reproduced by a hydrodynamic continuum model simulating division as a local pressure increase corresponding to a local tension decrease. Such long-range physical communication may be crucial for embryonic development and for healing tissue, for instance around blood clots.",

author = "Rossen, {Ninna Struck} and Tarp, {Jens Magelund} and Joachim Mathiesen and Jensen, {Mogens H{\o}gh} and Oddershede, {Lene Broeng}",

year = "2014",

month = dec,

day = "8",

doi = "10.1038/ncomms6720",

language = "English",

volume = "5",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "nature publishing group",

}

TY - JOUR

T1 - Long-range ordered vorticity patterns in living tissue induced by cell division

AU - Rossen, Ninna Struck

AU - Tarp, Jens Magelund

AU - Mathiesen, Joachim

AU - Jensen, Mogens Høgh

AU - Oddershede, Lene Broeng

PY - 2014/12/8

Y1 - 2014/12/8

N2 - In healthy blood vessels with a laminar blood flow, the endothelial cell division rate is low, only sufficient to replace apoptotic cells. The division rate significantly increases during embryonic development and under halted or turbulent flow. Cells in barrier tissue are connected and their motility is highly correlated. Here we investigate the long-range dynamics induced by cell division in an endothelial monolayer under non-flow conditions, mimicking the conditions during vessel formation or around blood clots. Cell divisions induce long-range, well-ordered vortex patterns extending several cell diameters away from the division site, in spite of the system's low Reynolds number. Our experimental results are reproduced by a hydrodynamic continuum model simulating division as a local pressure increase corresponding to a local tension decrease. Such long-range physical communication may be crucial for embryonic development and for healing tissue, for instance around blood clots.

AB - In healthy blood vessels with a laminar blood flow, the endothelial cell division rate is low, only sufficient to replace apoptotic cells. The division rate significantly increases during embryonic development and under halted or turbulent flow. Cells in barrier tissue are connected and their motility is highly correlated. Here we investigate the long-range dynamics induced by cell division in an endothelial monolayer under non-flow conditions, mimicking the conditions during vessel formation or around blood clots. Cell divisions induce long-range, well-ordered vortex patterns extending several cell diameters away from the division site, in spite of the system's low Reynolds number. Our experimental results are reproduced by a hydrodynamic continuum model simulating division as a local pressure increase corresponding to a local tension decrease. Such long-range physical communication may be crucial for embryonic development and for healing tissue, for instance around blood clots.

U2 - 10.1038/ncomms6720

DO - 10.1038/ncomms6720

M3 - Journal article

C2 - 25483750

SN - 2041-1723

VL - 5

JO - Nature Communications

JF - Nature Communications

M1 - 5720

ER -

Long-range ordered vorticity patterns in living tissue induced by cell division

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater