Long QT syndrome genotyping by electrocardiography: fact, fiction, or something in between?

TY - JOUR

T1 - Long QT syndrome genotyping by electrocardiography: fact, fiction, or something in between?

AU - Kanters, Jørgen K.

AU - Graff, Claus

AU - Andersen, Mads Peter

AU - Hardahl, Thomas Bork

AU - Toft, Egon

AU - Christiansen, Michael

AU - Bloch Thomsen, Poul Erik

AU - Struijk, Johannes J.

PY - 2006/10/1

Y1 - 2006/10/1

N2 - Diagnosis of long QT syndrome (LQTS) is difficult. A prolonged QT interval is easily overlooked, and in 10% of all patients with LQTS, the QT interval is normal. Genotyping is unfortunately not able to detect all patients and healthy subjects correctly. Although QT prolongation is the most used risk parameter, there is no clear correlation between the prolonged QT interval and the risk of arrhythmias in drug-induced LQTS. Quantification of T-wave morphology is a promising method that is able to provide more information about repolarization than QT prolongation alone. It is a fact that ECG evaluation can serve as a guide for genotyping and can reduce the costs by suggesting which gene to start sequencing, but it is fiction that the ECG can replace genotyping.

AB - Diagnosis of long QT syndrome (LQTS) is difficult. A prolonged QT interval is easily overlooked, and in 10% of all patients with LQTS, the QT interval is normal. Genotyping is unfortunately not able to detect all patients and healthy subjects correctly. Although QT prolongation is the most used risk parameter, there is no clear correlation between the prolonged QT interval and the risk of arrhythmias in drug-induced LQTS. Quantification of T-wave morphology is a promising method that is able to provide more information about repolarization than QT prolongation alone. It is a fact that ECG evaluation can serve as a guide for genotyping and can reduce the costs by suggesting which gene to start sequencing, but it is fiction that the ECG can replace genotyping.

KW - Calcium Channels

KW - Clinical Trials as Topic

KW - Electrocardiography

KW - Evidence-Based Medicine

KW - Genetic Predisposition to Disease

KW - Genetic Testing

KW - Genotype

KW - Humans

KW - Long QT Syndrome

KW - Reproducibility of Results

KW - Risk Assessment

KW - Risk Factors

KW - Sensitivity and Specificity

U2 - 10.1016/j.jelectrocard.2006.06.008

DO - 10.1016/j.jelectrocard.2006.06.008

M3 - Journal article

C2 - 16920146

SN - 1002-1094

VL - 39

SP - S119-22

JO - Xindianxue Zazhi

JF - Xindianxue Zazhi

IS - 4 Suppl

ER -