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Long-Acting Diclofenac Ester Prodrugs for Joint Injection: Kinetics, Mechanism of Degradation, and In Vitro Release From Prodrug Suspension
Nina Mertz
,
Susan Weng Larsen
,
Jesper Kristensen
,
Jesper Østergaard
,
Claus Larsen
8
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Alfabetisk
Medicin og biovidenskab
Diclofenac
95%
Prodrugs
90%
Esters
82%
Suspensions
71%
Kinetics
58%
Joints
57%
Injections
46%
Solubility
16%
Oxindoles
14%
phenylacetic acid
12%
imidazole
10%
Esterases
9%
Synovial Fluid
9%
Carbon
8%
Hydrolysis
7%
Dialysis
6%
In Vitro Techniques
3%
Pharmaceutical Preparations
3%
Kemiske forbindelser
Diclofenac
100%
Prodrug
86%
Suspension
62%
Ester
49%
Indolinone
13%
Phenylacetate
10%
pH Value
10%
Solubility
10%
Dialysis
7%
Dissolution
6%
Ethyl
5%
Cleavage
5%
Hydrolysis
5%
Plasma
5%
Length
4%
Drug
4%
Aqueous Solution
4%
Carbon Atom
3%
Reaction Yield
3%