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Long-Acting Diclofenac Ester Prodrugs for Joint Injection: Kinetics, Mechanism of Degradation, and In Vitro Release From Prodrug Suspension
Nina Mertz
,
Susan Weng Larsen
,
Jesper Kristensen
,
Jesper Østergaard
,
Claus Larsen
8
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Keyphrases
Prodrug
100%
Joint Injection
100%
Ester Prodrug
100%
Kinetic Mechanism
100%
Diclofenac
100%
Degradation Mechanism
100%
In Vitro Release
100%
PH Range
28%
PH-rate Profile
14%
Esterase
14%
Imidazole
14%
Carbon Chain Length
14%
After Injection
14%
Aqueous Solution
14%
Amino
14%
Ethyl
14%
Enzymatic Cleavage
14%
Human Plasma
14%
Dialysis
14%
Hydrolysis
14%
Human Synovial Fluid
14%
Physicochemical Properties
14%
1-Methyl
14%
Phenylacetate
14%
Rate Equations
14%
State of Charge
14%
Duration of Action
14%
Pharmacology, Toxicology and Pharmaceutical Science
Diclofenac
100%
Prodrug
100%
Esterase
8%
Imidazole
8%
Phenylacetic Acid
8%