Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls

Daisuke Yabe; Akira Kuroe; Soushou Lee; Koin Watanabe; Takanori Hyo; Masahiro Hishizawa; Takeshi Kurose; Carolyn F Deacon; Jens Juul Holst; Tsutomu Hirano; Nobuya Inagaki; Yutaka Seino

doi:10.1111/j.2040-1124.2010.00010.x

Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls

Daisuke Yabe, Akira Kuroe, Soushou Lee, Koin Watanabe, Takanori Hyo, Masahiro Hishizawa, Takeshi Kurose, Carolyn F Deacon, Jens Juul Holst, Tsutomu Hirano, Nobuya Inagaki, Yutaka Seino

Endocrinology and Metabolism

71 Citationer (Scopus)

Abstract

Although glucose-dependent insulinotropic polypeptide (GIP) levels have been characterized previously, GLP-1 levels in Asians remain unclear. Here, we investigate total and intact levels of GLP-1, as well as GIP during oral glucose and meal tolerance tests (OGTT and MTT) in Japanese patients with or without type 2 diabetes (T2DM). Seventeen Japanese healthy controls and 18 age-matched and untreated patients with T2DM of short duration participated in the present study. Fasting levels of total GPL-1 were similar between the two groups (approximately 15 pM), and intact GLP-1 levels were considerably low in both groups (less than 1 pM). In both groups, total GLP-1 reached a peak 30 min after glucose ingestion (30-40 pM), whereas intact GLP-1 levels remained low with no significant peak. In MTT, total and intact GLP-1 showed no obvious peak. The current data indicate that intact GLP-1 levels are considerably low in the Japanese and that meal-induced enhancement of GLP-1 secretion is negligible in the Japanese.

Originalsprog	Engelsk
Tidsskrift	Journal of Diabetes Investigation
Vol/bind	1
Udgave nummer	1-2
Sider (fra-til)	56-9
Antal sider	4
ISSN	2040-1116
DOI	https://doi.org/10.1111/j.2040-1124.2010.00010.x
Status	Udgivet - feb. 2010

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10.1111/j.2040-1124.2010.00010.x

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Yabe, D., Kuroe, A., Lee, S., Watanabe, K., Hyo, T., Hishizawa, M., Kurose, T., Deacon, C. F., Holst, J. J., Hirano, T., Inagaki, N., & Seino, Y. (2010). Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls. Journal of Diabetes Investigation, 1(1-2), 56-9. https://doi.org/10.1111/j.2040-1124.2010.00010.x

Yabe, D, Kuroe, A, Lee, S, Watanabe, K, Hyo, T, Hishizawa, M, Kurose, T, Deacon, CF , Holst, JJ, Hirano, T, Inagaki, N & Seino, Y 2010, 'Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls', Journal of Diabetes Investigation, bind 1, nr. 1-2, s. 56-9. https://doi.org/10.1111/j.2040-1124.2010.00010.x

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title = "Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls",

abstract = "Although glucose-dependent insulinotropic polypeptide (GIP) levels have been characterized previously, GLP-1 levels in Asians remain unclear. Here, we investigate total and intact levels of GLP-1, as well as GIP during oral glucose and meal tolerance tests (OGTT and MTT) in Japanese patients with or without type 2 diabetes (T2DM). Seventeen Japanese healthy controls and 18 age-matched and untreated patients with T2DM of short duration participated in the present study. Fasting levels of total GPL-1 were similar between the two groups (approximately 15 pM), and intact GLP-1 levels were considerably low in both groups (less than 1 pM). In both groups, total GLP-1 reached a peak 30 min after glucose ingestion (30-40 pM), whereas intact GLP-1 levels remained low with no significant peak. In MTT, total and intact GLP-1 showed no obvious peak. The current data indicate that intact GLP-1 levels are considerably low in the Japanese and that meal-induced enhancement of GLP-1 secretion is negligible in the Japanese.",

author = "Daisuke Yabe and Akira Kuroe and Soushou Lee and Koin Watanabe and Takanori Hyo and Masahiro Hishizawa and Takeshi Kurose and Deacon, {Carolyn F} and Holst, {Jens Juul} and Tsutomu Hirano and Nobuya Inagaki and Yutaka Seino",

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doi = "10.1111/j.2040-1124.2010.00010.x",

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T1 - Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese

T2 - Comparison of type 2 diabetes patients and healthy controls

AU - Yabe, Daisuke

AU - Kuroe, Akira

AU - Lee, Soushou

AU - Watanabe, Koin

AU - Hyo, Takanori

AU - Hishizawa, Masahiro

AU - Kurose, Takeshi

AU - Deacon, Carolyn F

AU - Holst, Jens Juul

AU - Hirano, Tsutomu

AU - Inagaki, Nobuya

AU - Seino, Yutaka

PY - 2010/2

Y1 - 2010/2

N2 - Although glucose-dependent insulinotropic polypeptide (GIP) levels have been characterized previously, GLP-1 levels in Asians remain unclear. Here, we investigate total and intact levels of GLP-1, as well as GIP during oral glucose and meal tolerance tests (OGTT and MTT) in Japanese patients with or without type 2 diabetes (T2DM). Seventeen Japanese healthy controls and 18 age-matched and untreated patients with T2DM of short duration participated in the present study. Fasting levels of total GPL-1 were similar between the two groups (approximately 15 pM), and intact GLP-1 levels were considerably low in both groups (less than 1 pM). In both groups, total GLP-1 reached a peak 30 min after glucose ingestion (30-40 pM), whereas intact GLP-1 levels remained low with no significant peak. In MTT, total and intact GLP-1 showed no obvious peak. The current data indicate that intact GLP-1 levels are considerably low in the Japanese and that meal-induced enhancement of GLP-1 secretion is negligible in the Japanese.

AB - Although glucose-dependent insulinotropic polypeptide (GIP) levels have been characterized previously, GLP-1 levels in Asians remain unclear. Here, we investigate total and intact levels of GLP-1, as well as GIP during oral glucose and meal tolerance tests (OGTT and MTT) in Japanese patients with or without type 2 diabetes (T2DM). Seventeen Japanese healthy controls and 18 age-matched and untreated patients with T2DM of short duration participated in the present study. Fasting levels of total GPL-1 were similar between the two groups (approximately 15 pM), and intact GLP-1 levels were considerably low in both groups (less than 1 pM). In both groups, total GLP-1 reached a peak 30 min after glucose ingestion (30-40 pM), whereas intact GLP-1 levels remained low with no significant peak. In MTT, total and intact GLP-1 showed no obvious peak. The current data indicate that intact GLP-1 levels are considerably low in the Japanese and that meal-induced enhancement of GLP-1 secretion is negligible in the Japanese.

U2 - 10.1111/j.2040-1124.2010.00010.x

DO - 10.1111/j.2040-1124.2010.00010.x

M3 - Journal article

C2 - 24843409

SN - 2040-1116

VL - 1

SP - 56

EP - 59

JO - Journal of Diabetes Investigation

JF - Journal of Diabetes Investigation

IS - 1-2

ER -

Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls

Abstract

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