TY - JOUR
T1 - Little enhancement of meal-induced GLP-1 secretion in Japanese: Comparison of type 2 diabetes and healthy controls
AU - Yabe, D
AU - Kuroe, A
AU - Lee, S
AU - Watanabe, K
AU - Hyo, T
AU - Hishizawa, M
AU - Kurose, T
AU - Deacon, Carolyn F.
AU - Holst, Jens Juul
AU - Hirano, T
AU - Inagaki, N
AU - Seino, Y
PY - 2010/1
Y1 - 2010/1
N2 - Although glucose-dependent insulinotropic polypeptide (GIP) levels have been characterized previously, GLP-1 levels in Asians remain unclear. Here, we investigate total and intact levels of GLP-1, as well as GIP during oral glucose and meal tolerance tests (OGTT and MTT) in Japanese patients with or without type 2 diabetes (T2DM). Seventeen Japanese healthy controls and 18 age-matched and untreated patients with T2DM of short duration participated in the present study. Fasting levels of total GPL-1 were similar between the two groups (approximately 15 pM), and intact GLP-1 levels were considerably low in both groups (less than 1 pM). In both groups, total GLP-1 reached a peak 30 min after glucose ingestion (30–40 pM), whereas intact GLP-1 levels remained low with no significant peak. In MTT, total and intact GLP-1 showed no obvious peak. The current data indicate that intact GLP-1 levels are considerably low in the Japanese and that meal-induced enhancement of GLP-1 secretion is negligible in the Japanese
AB - Although glucose-dependent insulinotropic polypeptide (GIP) levels have been characterized previously, GLP-1 levels in Asians remain unclear. Here, we investigate total and intact levels of GLP-1, as well as GIP during oral glucose and meal tolerance tests (OGTT and MTT) in Japanese patients with or without type 2 diabetes (T2DM). Seventeen Japanese healthy controls and 18 age-matched and untreated patients with T2DM of short duration participated in the present study. Fasting levels of total GPL-1 were similar between the two groups (approximately 15 pM), and intact GLP-1 levels were considerably low in both groups (less than 1 pM). In both groups, total GLP-1 reached a peak 30 min after glucose ingestion (30–40 pM), whereas intact GLP-1 levels remained low with no significant peak. In MTT, total and intact GLP-1 showed no obvious peak. The current data indicate that intact GLP-1 levels are considerably low in the Japanese and that meal-induced enhancement of GLP-1 secretion is negligible in the Japanese
U2 - 10.1111/j.2040-1124.2010.00010.x
DO - 10.1111/j.2040-1124.2010.00010.x
M3 - Journal article
C2 - 24843409
VL - 1
SP - 56
EP - 59
JO - Journal of Diabetes Investigation
JF - Journal of Diabetes Investigation
IS - 1/2
ER -
