Lipoprotein(a) and risk of type 2 diabetes

S. Mora; Pia R Kamstrup; N. Rifai; Børge G Nordestgaard; J.E. Buring; P.M. Ridker; Samia Mora; Nader Rifai; Julie E Buring; Paul M Ridker

doi:http://dx.doi.org/10.1373/clinchem.2010.146779

Lipoprotein(a) and risk of type 2 diabetes

S. Mora, Pia R Kamstrup, N. Rifai, Børge G Nordestgaard, J.E. Buring, P.M. Ridker, Samia Mora, Nader Rifai, Julie E Buring, Paul M Ridker

119 Citationer (Scopus)

Abstract

BACKGROUND: Previous studies have demonstrated that cardiovascular risk is higher with increased lipoprotein (a) [Lp(a)]. Whether Lp(a) concentration is related to type 2 diabetes is unclear. METHODS: In 26 746 healthy US women (mean age 54.6 years), we prospectively examined baseline Lp(a) concentrations and incident type 2 diabetes (n = 1670) for a follow-up period of 13 years. We confirmed our findings in 9652 Danish men and women with prevalent diabetes (n = 419). Analyses were adjusted for risk factors that included age, race, smoking, hormone use, family history, blood pressure, body mass index, hemoglobin A(1c) (Hb A(1c)), C-reactive protein, and lipids. RESULTS: Lp(a) was inversely associated with incident diabetes, with fully adjusted hazard ratios (HRs) and 95% CIs for quintiles 2-5 vs quintile 1 of 0.87 (0.75-1.01), 0.80 (0.68-0.93), 0.88 (0.76-1.02), and 0.78 (0.67-0.91); P for trend 0.002. The association was stronger in nonfasting women, for whom respective HRs were 0.79 (0.58-1.09), 0.78 (0.57-1.08), 0.66 (0.46-0.93), and 0.56 (0.40-0.80); P for trend 0.001; P for interaction with fasting status 0.002. When we used Lp(a) >= 10 mg/L and Hb A(1c) = 10 mg/L and Hb A(1c) 5%-

Originalsprog	Engelsk
Tidsskrift	Clinical Chemistry
Vol/bind	56
Udgave nummer	8
Sider (fra-til)	1252-60
Antal sider	9
ISSN	0009-9147
DOI	https://doi.org/10.1373/clinchem.2010.146779
Status	Udgivet - aug. 2010

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http://dx.doi.org/10.1373/clinchem.2010.146779

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@article{48b71e4021df4d3ba23d10e61d422d54,

title = "Lipoprotein(a) and risk of type 2 diabetes",

abstract = "BACKGROUND: Previous studies have demonstrated that cardiovascular risk is higher with increased lipoprotein(a) [Lp(a)]. Whether Lp(a) concentration is related to type 2 diabetes is unclear. METHODS: In 26 746 healthy US women (mean age 54.6 years), we prospectively examined baseline Lp(a) concentrations and incident type 2 diabetes (n = 1670) for a follow-up period of 13 years. We confirmed our findings in 9652 Danish men and women with prevalent diabetes (n = 419). Analyses were adjusted for risk factors that included age, race, smoking, hormone use, family history, blood pressure, body mass index, hemoglobin A 1c (Hb A1c), C-reactive protein, and lipids. RESULTS: Lp(a) was inversely associated with incident diabetes, with fully adjusted hazard ratios (HRs) and 95% CIs for quintiles 2-5 vs quintile 1 of 0.87 (0.75-1.01), 0.80 (0.68-0.93), 0.88 (0.76-1.02), and 0.78 (0.67-0.91); P for trend 0.002. The association was stronger in nonfasting women, for whom respective HRs were 0.79 (0.58-1.09), 0.78 (0.57-1.08), 0.66 (0.46-0.93), and 0.56 (0.40-0.80); P for trend 0.001; P for interaction with fasting status 0.002. When we used Lp(a) ≥10 mg/L and Hb A1c <5% as reference values, the adjusted HRs were 1.62 (0.91-2.89) for Lp(a) <10 mg/L and HbA1c<5%, 3.50 (3.06-4.01) for Lp(a)≥10 mg/L and Hb A 1c 5%-<6.5%, and 5.36 (4.00 -7.19) for Lp(a) <10 mg/L and Hb A1c 5%-<6.5%. Results were similar in nonfasting Danish men and women, for whom adjusted odds ratios were 0.75 (0.55-1.03), 0.64 (0.46-0.88), 0.74 (0.54 -1.01), and 0.58 (0.42- 0.79) for Lp(a) quintiles 2-5 vs quintile 1; P for trend 0.002. CONCLUSIONS: Our results indicated that Lp(a) was associated inversely with risk of type 2 diabetes independently of risk factors, in contrast to prior findings of positive associations of Lp(a) with cardiovascular risk.",

author = "S. Mora and Kamstrup, {Pia R} and N. Rifai and Nordestgaard, {B{\o}rge G} and J.E. Buring and P.M. Ridker and Samia Mora and Nader Rifai and Buring, {Julie E} and Ridker, {Paul M}",

year = "2010",

month = aug,

doi = "http://dx.doi.org/10.1373/clinchem.2010.146779",

language = "English",

volume = "56",

pages = "1252--60",

journal = "Clinical Chemistry",

issn = "0009-9147",

publisher = "American Association for Clinical Chemistry, Inc.",

number = "8",

}

TY - JOUR

T1 - Lipoprotein(a) and risk of type 2 diabetes

AU - Mora, S.

AU - Kamstrup, Pia R

AU - Rifai, N.

AU - Nordestgaard, Børge G

AU - Buring, J.E.

AU - Ridker, P.M.

AU - Mora, Samia

AU - Rifai, Nader

AU - Buring, Julie E

AU - Ridker, Paul M

PY - 2010/8

Y1 - 2010/8

N2 - BACKGROUND: Previous studies have demonstrated that cardiovascular risk is higher with increased lipoprotein(a) [Lp(a)]. Whether Lp(a) concentration is related to type 2 diabetes is unclear. METHODS: In 26 746 healthy US women (mean age 54.6 years), we prospectively examined baseline Lp(a) concentrations and incident type 2 diabetes (n = 1670) for a follow-up period of 13 years. We confirmed our findings in 9652 Danish men and women with prevalent diabetes (n = 419). Analyses were adjusted for risk factors that included age, race, smoking, hormone use, family history, blood pressure, body mass index, hemoglobin A 1c (Hb A1c), C-reactive protein, and lipids. RESULTS: Lp(a) was inversely associated with incident diabetes, with fully adjusted hazard ratios (HRs) and 95% CIs for quintiles 2-5 vs quintile 1 of 0.87 (0.75-1.01), 0.80 (0.68-0.93), 0.88 (0.76-1.02), and 0.78 (0.67-0.91); P for trend 0.002. The association was stronger in nonfasting women, for whom respective HRs were 0.79 (0.58-1.09), 0.78 (0.57-1.08), 0.66 (0.46-0.93), and 0.56 (0.40-0.80); P for trend 0.001; P for interaction with fasting status 0.002. When we used Lp(a) ≥10 mg/L and Hb A1c <5% as reference values, the adjusted HRs were 1.62 (0.91-2.89) for Lp(a) <10 mg/L and HbA1c<5%, 3.50 (3.06-4.01) for Lp(a)≥10 mg/L and Hb A 1c 5%-<6.5%, and 5.36 (4.00 -7.19) for Lp(a) <10 mg/L and Hb A1c 5%-<6.5%. Results were similar in nonfasting Danish men and women, for whom adjusted odds ratios were 0.75 (0.55-1.03), 0.64 (0.46-0.88), 0.74 (0.54 -1.01), and 0.58 (0.42- 0.79) for Lp(a) quintiles 2-5 vs quintile 1; P for trend 0.002. CONCLUSIONS: Our results indicated that Lp(a) was associated inversely with risk of type 2 diabetes independently of risk factors, in contrast to prior findings of positive associations of Lp(a) with cardiovascular risk.

AB - BACKGROUND: Previous studies have demonstrated that cardiovascular risk is higher with increased lipoprotein(a) [Lp(a)]. Whether Lp(a) concentration is related to type 2 diabetes is unclear. METHODS: In 26 746 healthy US women (mean age 54.6 years), we prospectively examined baseline Lp(a) concentrations and incident type 2 diabetes (n = 1670) for a follow-up period of 13 years. We confirmed our findings in 9652 Danish men and women with prevalent diabetes (n = 419). Analyses were adjusted for risk factors that included age, race, smoking, hormone use, family history, blood pressure, body mass index, hemoglobin A 1c (Hb A1c), C-reactive protein, and lipids. RESULTS: Lp(a) was inversely associated with incident diabetes, with fully adjusted hazard ratios (HRs) and 95% CIs for quintiles 2-5 vs quintile 1 of 0.87 (0.75-1.01), 0.80 (0.68-0.93), 0.88 (0.76-1.02), and 0.78 (0.67-0.91); P for trend 0.002. The association was stronger in nonfasting women, for whom respective HRs were 0.79 (0.58-1.09), 0.78 (0.57-1.08), 0.66 (0.46-0.93), and 0.56 (0.40-0.80); P for trend 0.001; P for interaction with fasting status 0.002. When we used Lp(a) ≥10 mg/L and Hb A1c <5% as reference values, the adjusted HRs were 1.62 (0.91-2.89) for Lp(a) <10 mg/L and HbA1c<5%, 3.50 (3.06-4.01) for Lp(a)≥10 mg/L and Hb A 1c 5%-<6.5%, and 5.36 (4.00 -7.19) for Lp(a) <10 mg/L and Hb A1c 5%-<6.5%. Results were similar in nonfasting Danish men and women, for whom adjusted odds ratios were 0.75 (0.55-1.03), 0.64 (0.46-0.88), 0.74 (0.54 -1.01), and 0.58 (0.42- 0.79) for Lp(a) quintiles 2-5 vs quintile 1; P for trend 0.002. CONCLUSIONS: Our results indicated that Lp(a) was associated inversely with risk of type 2 diabetes independently of risk factors, in contrast to prior findings of positive associations of Lp(a) with cardiovascular risk.

U2 - http://dx.doi.org/10.1373/clinchem.2010.146779

DO - http://dx.doi.org/10.1373/clinchem.2010.146779

M3 - Journal article

SN - 0009-9147

VL - 56

SP - 1252

EP - 1260

JO - Clinical Chemistry

JF - Clinical Chemistry

IS - 8

ER -

Lipoprotein(a) and risk of type 2 diabetes

Abstract

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