@inbook{6177a3d1e08048cba328da5ac94d5ece,
title = "Linkers, resins, and general procedures for solid-phase peptide synthesis",
abstract = "This chapter describes the basic protocols for solid-phase peptide synthesis using the Fmoc group as the N α-protecting group (Fmoc-SPPS). The chapter introduces resins and their handling, choice of linkers, and the most common methods for peptide chain assembly. The proper choice of resins and linkers for solid-phase synthesis is a key parameter for successful peptide synthesis. This chapter provides an overview of the most common and useful resins and linkers for the synthesis of peptides with C-terminal amides, carboxylic acids, and more. The chapter finishes with robust protocols for general solid-phase peptide synthesis, i.e., the standard operations.",
keywords = "Solid-phase peptide synthesis, SPPS, TentaGel, ChemMatrix, PEGA, Polystyrene, HBTU, HATU, DIC, COMU, HOBt, HOAt, Oxyma",
author = "Shelton, {Anne Pernille Tofteng} and Jensen, {Knud J{\o}rgen}",
year = "2013",
doi = "10.1007/978-1-62703-544-6_2",
language = "English",
isbn = "978-1-62703-543-9",
series = "Methods in Molecular Biology",
publisher = "Humana Press",
pages = "23--41",
editor = "Jensen, {Knud J.} and Shelton, {Pernille T.} and Pedersen, {S{\o}ren L.}",
booktitle = "Peptide synthesis and applications",
address = "United States",
}