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Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors
Qian Wang,
Stephan Alexander Pless
, Joseph W Lynch
15
Citationer (Scopus)
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Keyphrases
GABAA Receptor (GABAAR)
100%
Ligand-binding Domain
100%
Conformational Change
100%
Linker
100%
Subunit Interface
60%
Cys-loop Receptor
60%
Voltage-clamp Fluorometry
40%
Homomeric
40%
Structural Rearrangement
20%
Induced Fluorescence
20%
Agonist Binding
20%
Closed State
20%
Fluorescence Change
20%
Receptor-ligand Binding
20%
C-closure
20%
Conformational Mobility
20%
Ligand Binding Site
20%
Fluorophore
20%
Cysteine
20%
Binding Site
20%
Activation Mechanism
20%
Ligand Binding
20%
2 Receptor
20%
Disulfide
20%
Large Conformational Changes
20%
Environment-sensitive Fluorophore
20%
Biochemistry, Genetics and Molecular Biology
Ligand Binding Domain
100%
Conformational Change
100%
Isoetarine
100%
GABAA Receptor
100%
Cys-Loop Receptors
50%
Agonist
50%
Binding Site
33%
Voltage Clamp
33%
Ligand Binding
33%
Conformation
16%
Disulfide
16%
Gamma-Aminobutyric Acid
16%
Cysteine
16%