Less known aspects of central hypothyroidism: Part 1 - Acquired etiologies

TY - JOUR

T1 - Less known aspects of central hypothyroidism

T2 - Part 1 - Acquired etiologies

AU - Benvenga, Salvatore

AU - Klose, Marianne

AU - Vita, Roberto

AU - Feldt-Rasmussen, Ulla

PY - 2018/12

Y1 - 2018/12

N2 - Central hypothyroidism (CH) is a rare cause of hypothyroidism. CH is frequently overlooked, as its clinical picture is subtle and includes non-specific symptoms; furthermore, if measurement of TSH alone is used to screen for thyroid function, TSH concentrations can be normal or even above the upper normal reference limit. Indeed, certain patients are at risk of developing CH, such as those with a pituitary adenoma or hypophysitis, those who have been treated for a childhood malignancy, have suffered a head trauma, sub-arachnoid hemorrhage or meningitis, and those who are on drugs capable to reduce TSH secretion.

AB - Central hypothyroidism (CH) is a rare cause of hypothyroidism. CH is frequently overlooked, as its clinical picture is subtle and includes non-specific symptoms; furthermore, if measurement of TSH alone is used to screen for thyroid function, TSH concentrations can be normal or even above the upper normal reference limit. Indeed, certain patients are at risk of developing CH, such as those with a pituitary adenoma or hypophysitis, those who have been treated for a childhood malignancy, have suffered a head trauma, sub-arachnoid hemorrhage or meningitis, and those who are on drugs capable to reduce TSH secretion.

U2 - 10.1016/j.jcte.2018.09.003

DO - 10.1016/j.jcte.2018.09.003

M3 - Review

C2 - 30416972

SN - 2214-6237

VL - 14

SP - 25

EP - 33

JO - Journal of Clinical and Translational Endocrinology

JF - Journal of Clinical and Translational Endocrinology

ER -