Legacy data sharing to improve drug safety assessment: the eTOX project

Ferran Sanz; François Pognan; Thomas Steger-Hartmann; Carlos Díaz; Montserrat Cases; Manuel Pastor; Philippe Marc; Joerg Wichard; Katharine Briggs; David K Watson; Thomas Kleinöder; Chihae Yang; Alexander Amberg; Maria Beaumont; Anthony J Brookes; Søren Brunak; Mark T D Cronin; Gerhard F Ecker; Sylvia Escher; Nigel Greene; Antonio Guzmán; Anne Hersey; Pascale Jacques; Lieve Lammens; Jordi Mestres; Wolfgang Muster; Helle Northeved; Marc Pinches; Javier Saiz; Nicolas Sajot; Alfonso Valencia; Johan van der Lei; Nico P E Vermeulen; Esther Vock; Gerhard Wolber; Ismael Zamora; eTOX

doi:10.1038/nrd.2017.177

Legacy data sharing to improve drug safety assessment: the eTOX project

Ferran Sanz, François Pognan, Thomas Steger-Hartmann, Carlos Díaz, Montserrat Cases, Manuel Pastor, Philippe Marc, Joerg Wichard, Katharine Briggs, David K Watson, Thomas Kleinöder, Chihae Yang, Alexander Amberg, Maria Beaumont, Anthony J Brookes, Søren Brunak, Mark T D Cronin, Gerhard F Ecker, Sylvia Escher, Nigel GreeneAntonio Guzmán, Anne Hersey, Pascale Jacques, Lieve Lammens, Jordi Mestres, Wolfgang Muster, Helle Northeved, Marc Pinches, Javier Saiz, Nicolas Sajot, Alfonso Valencia, Johan van der Lei, Nico P E Vermeulen, Esther Vock, Gerhard Wolber, Ismael Zamora, eTOX

27 Citationer (Scopus)

Abstract

The sharing of legacy preclinical safety data among pharmaceutical companies and its integration with other information sources offers unprecedented opportunities to improve the early assessment of drug safety. Here, we discuss the experience of the eTOX project, which was established through the Innovative Medicines Initiative to explore this possibility.

Originalsprog	Engelsk
Tidsskrift	Nature Reviews. Drug Discovery
Vol/bind	16
Udgave nummer	12
Sider (fra-til)	811-812
Antal sider	2
ISSN	1474-1776
DOI	https://doi.org/10.1038/nrd.2017.177
Status	Udgivet - 28 nov. 2017
Udgivet eksternt	Ja

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10.1038/nrd.2017.177

Citationsformater

Sanz, F., Pognan, F., Steger-Hartmann, T., Díaz, C., Cases, M., Pastor, M., Marc, P., Wichard, J., Briggs, K., Watson, D. K., Kleinöder, T., Yang, C., Amberg, A., Beaumont, M., Brookes, A. J., Brunak, S., Cronin, M. T. D., Ecker, G. F., Escher, S., ... eTOX (2017). Legacy data sharing to improve drug safety assessment: the eTOX project. Nature Reviews. Drug Discovery, 16(12), 811-812. https://doi.org/10.1038/nrd.2017.177

Sanz, F, Pognan, F, Steger-Hartmann, T, Díaz, C, Cases, M, Pastor, M, Marc, P, Wichard, J, Briggs, K, Watson, DK, Kleinöder, T, Yang, C, Amberg, A, Beaumont, M, Brookes, AJ, Brunak, S, Cronin, MTD, Ecker, GF, Escher, S, Greene, N, Guzmán, A, Hersey, A, Jacques, P, Lammens, L, Mestres, J, Muster, W, Northeved, H, Pinches, M, Saiz, J, Sajot, N, Valencia, A, van der Lei, J, Vermeulen, NPE, Vock, E, Wolber, G, Zamora, I & eTOX 2017, 'Legacy data sharing to improve drug safety assessment: the eTOX project', Nature Reviews. Drug Discovery, bind 16, nr. 12, s. 811-812. https://doi.org/10.1038/nrd.2017.177

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AU - Sanz, Ferran

AU - Pognan, François

AU - Steger-Hartmann, Thomas

AU - Díaz, Carlos

AU - Cases, Montserrat

AU - Pastor, Manuel

AU - Marc, Philippe

AU - Wichard, Joerg

AU - Briggs, Katharine

AU - Watson, David K

AU - Kleinöder, Thomas

AU - Yang, Chihae

AU - Amberg, Alexander

AU - Beaumont, Maria

AU - Brookes, Anthony J

AU - Brunak, Søren

AU - Cronin, Mark T D

AU - Ecker, Gerhard F

AU - Escher, Sylvia

AU - Greene, Nigel

AU - Guzmán, Antonio

AU - Hersey, Anne

AU - Jacques, Pascale

AU - Lammens, Lieve

AU - Mestres, Jordi

AU - Muster, Wolfgang

AU - Northeved, Helle

AU - Pinches, Marc

AU - Saiz, Javier

AU - Sajot, Nicolas

AU - Valencia, Alfonso

AU - van der Lei, Johan

AU - Vermeulen, Nico P E

AU - Vock, Esther

AU - Wolber, Gerhard

AU - Zamora, Ismael

AU - eTOX

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AB - The sharing of legacy preclinical safety data among pharmaceutical companies and its integration with other information sources offers unprecedented opportunities to improve the early assessment of drug safety. Here, we discuss the experience of the eTOX project, which was established through the Innovative Medicines Initiative to explore this possibility.

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Legacy data sharing to improve drug safety assessment: the eTOX project

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