Late midlife C-reactive protein and interleukin-6 in middle aged danish men in relation to body size history within and across generations

TY - JOUR

T1 - Late midlife C-reactive protein and interleukin-6 in middle aged danish men in relation to body size history within and across generations

AU - Pedersen, Jolene Lee Masters

AU - Budtz-Jørgensen, Esben

AU - Mortensen, Erik Lykke

AU - Bruunsgaard, Helle

AU - Osler, Merete

AU - Sørensen, Thorkild I A

AU - Rod, Naja Hulvej

AU - Lund, Rikke

N1 - © 2015 The Obesity Society.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - OBJECTIVE: The aim was to estimate the effects of ponderal index at birth and body mass index (BMI) in early adulthood on C-reactive protein (CRP) and interleukin-6 (IL-6) and to quantify the effects through subsequent measures of body size. In a subanalysis, the contributions of maternal BMI to the inflammatory status of offspring were investigated.METHODS: The study was based on 2,986 Danish males from the Copenhagen Aging and Midlife Biobank. Path analysis was employed to estimate direct and indirect effects.RESULTS: A 10% higher maternal BMI was associated with 7% higher CRP and 3% higher IL-6 among offspring. A 10% higher ponderal index at birth was associated with 4% lower CRP in late midlife; this effect was only partially mediated by later growth. A 10% higher BMI in early adulthood was associated with 8% higher CRP and 4% higher IL-6 in late midlife. The findings suggest that weight gain in adulthood is associated with low-grade inflammation in late midlife.CONCLUSIONS: Ponderal index at birth is associated with CRP in later life independently of adult BMI. The findings additionally suggest that preventing weight gain in early adulthood would be beneficial for inflammatory status in later life.

AB - OBJECTIVE: The aim was to estimate the effects of ponderal index at birth and body mass index (BMI) in early adulthood on C-reactive protein (CRP) and interleukin-6 (IL-6) and to quantify the effects through subsequent measures of body size. In a subanalysis, the contributions of maternal BMI to the inflammatory status of offspring were investigated.METHODS: The study was based on 2,986 Danish males from the Copenhagen Aging and Midlife Biobank. Path analysis was employed to estimate direct and indirect effects.RESULTS: A 10% higher maternal BMI was associated with 7% higher CRP and 3% higher IL-6 among offspring. A 10% higher ponderal index at birth was associated with 4% lower CRP in late midlife; this effect was only partially mediated by later growth. A 10% higher BMI in early adulthood was associated with 8% higher CRP and 4% higher IL-6 in late midlife. The findings suggest that weight gain in adulthood is associated with low-grade inflammation in late midlife.CONCLUSIONS: Ponderal index at birth is associated with CRP in later life independently of adult BMI. The findings additionally suggest that preventing weight gain in early adulthood would be beneficial for inflammatory status in later life.

UR - http://www.scopus.com/inward/record.url?scp=84956580526&partnerID=8YFLogxK

U2 - 10.1002/oby.21311

DO - 10.1002/oby.21311

M3 - Journal article

C2 - 26718895

SN - 1930-7381

VL - 24

SP - 461

EP - 468

JO - Obesity

JF - Obesity

IS - 2

ER -