Late malignant transformation of vestibular schwannoma in the absence of irradiation: case report

Asma Bashir; Lars Poulsgaard; Helle Broholm; Kåre Fugleholm

doi:10.3171/2015.6.jns1544

Late malignant transformation of vestibular schwannoma in the absence of irradiation: case report

Asma Bashir, Lars Poulsgaard, Helle Broholm, Kåre Fugleholm

Institut for Klinisk Medicin

7 Citationer (Scopus)

Abstract

Late malignant transformation of vestibular schwannoma (VS) following irradiation has previously been reported 29 times in the literature. Here, the authors report the first late malignant transformation of VS unrelated to neurofibromatosis or radiation exposure. After undergoing a near-total excision of a histologically benign VS, the patient developed malignant regrowth of the tumor remnant 42 months after the primary excision. This case challenges the dogmatic belief of absolute causality between radiation exposure and late malignant transformation of VS, and has important implications regarding future counseling and consent for the treatment of patients with VS.

Originalsprog	Engelsk
Tidsskrift	Journal of Neurosurgery
Vol/bind	125
Udgave nummer	2
Sider (fra-til)	372-7
Antal sider	6
ISSN	0022-3085
DOI	https://doi.org/10.3171/2015.6.jns1544
Status	Udgivet - aug. 2016

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10.3171/2015.6.jns1544

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abstract = "Late malignant transformation of vestibular schwannoma (VS) following irradiation has previously been reported 29 times in the literature. Here, the authors report the first late malignant transformation of VS unrelated to neurofibromatosis or radiation exposure. After undergoing a near-total excision of a histologically benign VS, the patient developed malignant regrowth of the tumor remnant 42 months after the primary excision. This case challenges the dogmatic belief of absolute causality between radiation exposure and late malignant transformation of VS, and has important implications regarding future counseling and consent for the treatment of patients with VS.",

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AB - Late malignant transformation of vestibular schwannoma (VS) following irradiation has previously been reported 29 times in the literature. Here, the authors report the first late malignant transformation of VS unrelated to neurofibromatosis or radiation exposure. After undergoing a near-total excision of a histologically benign VS, the patient developed malignant regrowth of the tumor remnant 42 months after the primary excision. This case challenges the dogmatic belief of absolute causality between radiation exposure and late malignant transformation of VS, and has important implications regarding future counseling and consent for the treatment of patients with VS.

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Late malignant transformation of vestibular schwannoma in the absence of irradiation: case report

Abstract

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