Late malignant transformation of vestibular schwannoma in the absence of irradiation: case report

TY - JOUR

T1 - Late malignant transformation of vestibular schwannoma in the absence of irradiation

T2 - case report

AU - Bashir, Asma

AU - Poulsgaard, Lars

AU - Broholm, Helle

AU - Fugleholm, Kåre

PY - 2016/8

Y1 - 2016/8

N2 - Late malignant transformation of vestibular schwannoma (VS) following irradiation has previously been reported 29 times in the literature. Here, the authors report the first late malignant transformation of VS unrelated to neurofibromatosis or radiation exposure. After undergoing a near-total excision of a histologically benign VS, the patient developed malignant regrowth of the tumor remnant 42 months after the primary excision. This case challenges the dogmatic belief of absolute causality between radiation exposure and late malignant transformation of VS, and has important implications regarding future counseling and consent for the treatment of patients with VS.

AB - Late malignant transformation of vestibular schwannoma (VS) following irradiation has previously been reported 29 times in the literature. Here, the authors report the first late malignant transformation of VS unrelated to neurofibromatosis or radiation exposure. After undergoing a near-total excision of a histologically benign VS, the patient developed malignant regrowth of the tumor remnant 42 months after the primary excision. This case challenges the dogmatic belief of absolute causality between radiation exposure and late malignant transformation of VS, and has important implications regarding future counseling and consent for the treatment of patients with VS.

KW - Journal Article

U2 - 10.3171/2015.6.jns1544

DO - 10.3171/2015.6.jns1544

M3 - Journal article

C2 - 26613171

SN - 0022-3085

VL - 125

SP - 372

EP - 377

JO - Journal of Neurosurgery

JF - Journal of Neurosurgery

IS - 2

ER -