Lactase Persistence, Milk Intake, and Adult Acne: A Mendelian Randomization Study of 20,416 Danish Adults

TY - JOUR

T1 - Lactase Persistence, Milk Intake, and Adult Acne

T2 - A Mendelian Randomization Study of 20,416 Danish Adults

AU - Juhl, Christian R

AU - Bergholdt, Helle K M

AU - Miller, Iben M

AU - Jemec, Gregor B E

AU - Kanters, Jørgen K

AU - Ellervik, Christina

PY - 2018/8/8

Y1 - 2018/8/8

N2 - Whether there is a causal relationship between milk intake and acne is unknown. We tested the hypothesis that genetically determined milk intake is associated with acne in adults using a Mendelian randomization design. LCT-13910 C/T (rs4988235) is associated with lactase persistence (TT/TC) in Northern Europeans. We investigated the association between milk intake, LCT-13910 C/T (rs4988235), and acne in 20,416 adults (age-range: 20⁻96) from The Danish General Suburban Population Study (GESUS). The adjusted observational odds ratio for acne in any milk intake vs. no milk intake was 0.93(95% confidence interval: 0.48⁻1.78) in females and 0.49(0.22⁻1.08) in males aged 20⁻39 years, and 1.15(95% confidence interval: 0.66⁻1.99) in females and 1.02(0.61⁻1.72) in males above 40 years. The unadjusted odds ratio for acne in TT+TC vs. CC was 0.84(0.43⁻1.62) in the age group 20⁻39 years, and 0.99(0.52⁻1.88) above 40 years. We did not find any observational or genetic association between milk intake and acne in our population of adults.

AB - Whether there is a causal relationship between milk intake and acne is unknown. We tested the hypothesis that genetically determined milk intake is associated with acne in adults using a Mendelian randomization design. LCT-13910 C/T (rs4988235) is associated with lactase persistence (TT/TC) in Northern Europeans. We investigated the association between milk intake, LCT-13910 C/T (rs4988235), and acne in 20,416 adults (age-range: 20⁻96) from The Danish General Suburban Population Study (GESUS). The adjusted observational odds ratio for acne in any milk intake vs. no milk intake was 0.93(95% confidence interval: 0.48⁻1.78) in females and 0.49(0.22⁻1.08) in males aged 20⁻39 years, and 1.15(95% confidence interval: 0.66⁻1.99) in females and 1.02(0.61⁻1.72) in males above 40 years. The unadjusted odds ratio for acne in TT+TC vs. CC was 0.84(0.43⁻1.62) in the age group 20⁻39 years, and 0.99(0.52⁻1.88) above 40 years. We did not find any observational or genetic association between milk intake and acne in our population of adults.

KW - Acne

KW - Acne vulgaris

KW - Adults

KW - Dairy

KW - Diet

KW - Mendelian randomization

KW - Milk

UR - http://www.scopus.com/inward/record.url?scp=85051390176&partnerID=8YFLogxK

U2 - 10.3390/nu10081041

DO - 10.3390/nu10081041

M3 - Journal article

C2 - 30096803

SN - 2072-6643

VL - 10

JO - Nutrients

JF - Nutrients

IS - 8

M1 - 1041

ER -