Lab-on-a-chip technologies for stem cell analysis

Peter Ertl; Drago Sticker; Verena Charwat; Cornelia Kasper; Günter Lepperdinger

doi:10.1016/j.tibtech.2014.03.004

Lab-on-a-chip technologies for stem cell analysis

Peter Ertl, Drago Sticker, Verena Charwat, Cornelia Kasper, Günter Lepperdinger

77 Citationer (Scopus)

Abstract

The combination of microfabrication-based technologies with cell biology has laid the foundation for the development of advanced in vitro diagnostic systems capable of analyzing cell cultures under physiologically relevant conditions. In the present review, we address recent lab-on-a-chip developments for stem cell analysis. We highlight in particular the tangible advantages of microfluidic devices to overcome most of the challenges associated with stem cell identification, expansion and differentiation, with the greatest advantage being that lab-on-a-chip technology allows for the precise regulation of culturing conditions, while simultaneously monitoring relevant parameters using embedded sensory systems. State-of-the-art lab-on-a-chip platforms for in vitro assessment of stem cell cultures are presented and their potential future applications discussed.

Originalsprog	Engelsk
Tidsskrift	Trends in Biotechnology
Vol/bind	32
Udgave nummer	5
Sider (fra-til)	245-53
Antal sider	9
ISSN	0167-7799
DOI	https://doi.org/10.1016/j.tibtech.2014.03.004
Status	Udgivet - maj 2014
Udgivet eksternt	Ja

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10.1016/j.tibtech.2014.03.004

Citationsformater

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title = "Lab-on-a-chip technologies for stem cell analysis",

abstract = "The combination of microfabrication-based technologies with cell biology has laid the foundation for the development of advanced in vitro diagnostic systems capable of analyzing cell cultures under physiologically relevant conditions. In the present review, we address recent lab-on-a-chip developments for stem cell analysis. We highlight in particular the tangible advantages of microfluidic devices to overcome most of the challenges associated with stem cell identification, expansion and differentiation, with the greatest advantage being that lab-on-a-chip technology allows for the precise regulation of culturing conditions, while simultaneously monitoring relevant parameters using embedded sensory systems. State-of-the-art lab-on-a-chip platforms for in vitro assessment of stem cell cultures are presented and their potential future applications discussed.",

keywords = "Cytological Techniques, Humans, Lab-On-A-Chip Devices, Microfluidic Analytical Techniques, Stem Cells, Journal Article, Review",

author = "Peter Ertl and Drago Sticker and Verena Charwat and Cornelia Kasper and G{\"u}nter Lepperdinger",

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T1 - Lab-on-a-chip technologies for stem cell analysis

AU - Ertl, Peter

AU - Sticker, Drago

AU - Charwat, Verena

AU - Kasper, Cornelia

AU - Lepperdinger, Günter

PY - 2014/5

Y1 - 2014/5

N2 - The combination of microfabrication-based technologies with cell biology has laid the foundation for the development of advanced in vitro diagnostic systems capable of analyzing cell cultures under physiologically relevant conditions. In the present review, we address recent lab-on-a-chip developments for stem cell analysis. We highlight in particular the tangible advantages of microfluidic devices to overcome most of the challenges associated with stem cell identification, expansion and differentiation, with the greatest advantage being that lab-on-a-chip technology allows for the precise regulation of culturing conditions, while simultaneously monitoring relevant parameters using embedded sensory systems. State-of-the-art lab-on-a-chip platforms for in vitro assessment of stem cell cultures are presented and their potential future applications discussed.

AB - The combination of microfabrication-based technologies with cell biology has laid the foundation for the development of advanced in vitro diagnostic systems capable of analyzing cell cultures under physiologically relevant conditions. In the present review, we address recent lab-on-a-chip developments for stem cell analysis. We highlight in particular the tangible advantages of microfluidic devices to overcome most of the challenges associated with stem cell identification, expansion and differentiation, with the greatest advantage being that lab-on-a-chip technology allows for the precise regulation of culturing conditions, while simultaneously monitoring relevant parameters using embedded sensory systems. State-of-the-art lab-on-a-chip platforms for in vitro assessment of stem cell cultures are presented and their potential future applications discussed.

KW - Cytological Techniques

KW - Humans

KW - Lab-On-A-Chip Devices

KW - Microfluidic Analytical Techniques

KW - Stem Cells

KW - Journal Article

KW - Review

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DO - 10.1016/j.tibtech.2014.03.004

M3 - Review

C2 - 24726257

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VL - 32

SP - 245

EP - 253

JO - Trends in Biotechnology

JF - Trends in Biotechnology

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ER -

Lab-on-a-chip technologies for stem cell analysis

Abstract

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