Kombinationsbehandling med thyroxin og trijodthyronin til patienter med hypotyreose

TY - JOUR

T1 - Kombinationsbehandling med thyroxin og trijodthyronin til patienter med hypotyreose

AU - Nygaard, Birte

AU - Røder, Michael E

AU - Karmisholt, Jesper

AU - Kristensen, Jette Kolding

PY - 2018

Y1 - 2018

N2 - Decreased quality of life is described more often in hypothyroid patients, who are treated with a synthetic form of thyroxine (L-T4), than in euthyroid controls. A combination of L-T4 and a synthetic form of triiodothyronine (L-T3) has been suggested; however, previous meta-analyses on unselected patients did not find any effect. Recent studies demonstrate, that the overall hypothalamic-pituitary-thyroid-tissue homeostasis could be more complex than previously suggested. Polymorphisms in deiodinase and thyroid hormone transporter genes could theoretically explain, why a minor subgroup of hypothyroid patients seem to have an effect of L-T4/L-T3 combination therapy.

AB - Decreased quality of life is described more often in hypothyroid patients, who are treated with a synthetic form of thyroxine (L-T4), than in euthyroid controls. A combination of L-T4 and a synthetic form of triiodothyronine (L-T3) has been suggested; however, previous meta-analyses on unselected patients did not find any effect. Recent studies demonstrate, that the overall hypothalamic-pituitary-thyroid-tissue homeostasis could be more complex than previously suggested. Polymorphisms in deiodinase and thyroid hormone transporter genes could theoretically explain, why a minor subgroup of hypothyroid patients seem to have an effect of L-T4/L-T3 combination therapy.

KW - Drug Therapy, Combination

KW - Humans

KW - Hypothyroidism/drug therapy

KW - Thyroid Hormones/physiology

KW - Thyroxine/administration & dosage

KW - Triiodothyronine/administration & dosage

M3 - Tidsskriftartikel

C2 - 29761770

SN - 0041-5782

VL - 180

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 19

M1 - V04170328

ER -