Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes

Medicin og biovidenskab

• Amyloid beta-Protein Precursor 100%
• Alzheimer Disease 66%
• Amyloid 61%
• Phenotype 51%
• Gene Knock-In Techniques 36%
• peptide A 32%
• Hypoxanthine Phosphoribosyltransferase 29%
• Piriform Cortex 28%
• Food Preferences 28%
• Endophenotypes 28%
• Calcium-Calmodulin-Dependent Protein Kinase Type 2 27%
• Spatial Learning 26%
• Gliosis 25%
• Dentate Gyrus 23%
• Prosencephalon 23%
• Semantics 22%
• Brain 21%
• Parietal Lobe 21%
• Locomotion 20%
• Short-Term Memory 20%
• Rodentia 17%
• Cognitive Dysfunction 17%
• Hippocampus 17%
• Poisons 16%
• Memory 15%
• Anxiety 15%
• Water 14%
• Pathology 13%
• Inflammation 12%
• Enzymes 11%