Kinetics of del(7 q) driven leukemogenesis in a patient with JAK2 V617F and TET2 mutated chronic myeloproliferative neoplasm

Laura Laine Herborg; Line Nederby; Eigil Kjeldsen; Kirsten Grønbæk; Peter Hokland; Camilla Maria Holm Hansen; Marcus Celik Hansen; Anne Stidsholt Roug

doi:10.1016/j.lrr.2013.06.001

Kinetics of del(7 q) driven leukemogenesis in a patient with JAK2 V617F and TET2 mutated chronic myeloproliferative neoplasm

Laura Laine Herborg, Line Nederby, Eigil Kjeldsen, Kirsten Grønbæk, Peter Hokland, Camilla Maria Holm Hansen, Marcus Celik Hansen, Anne Stidsholt Roug

Institut for Klinisk Medicin

1 Citationer (Scopus)

Abstract

Chronic myeloid neoplasms have susceptibility to transform into acute myeloid leukemia due to attainment of additional molecular lesions. We here describe the kinetics of a del(7q) driven leukemogenesis in a patient with multiple TET2 mutations and JAK2 V617F mutated chronic myeloproliferative neoplasm. The del(7q) emerged in the accelerated phase of disease, which was preceded by a lag phase of almost three years with normalized peripheral blood cell counts. Our results reveal that the del(7q), independently of other lesions, acts as a leukemic driver in this patient and that the stable long-lasting normalization of peripheral blood cell values concealed pending transformation.

Originalsprog	Engelsk
Tidsskrift	Leukemia Research Reports
Vol/bind	2
Udgave nummer	2
Sider (fra-til)	51-53
Antal sider	3
ISSN	2213-0489
DOI	https://doi.org/10.1016/j.lrr.2013.06.001
Status	Udgivet - 2013

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10.1016/j.lrr.2013.06.001

Citationsformater

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title = "Kinetics of del(7 q) driven leukemogenesis in a patient with JAK2 V617F and TET2 mutated chronic myeloproliferative neoplasm",

abstract = "Chronic myeloid neoplasms have susceptibility to transform into acute myeloid leukemia due to attainment of additional molecular lesions. We here describe the kinetics of a del(7q) driven leukemogenesis in a patient with multiple TET2 mutations and JAK2 V617F mutated chronic myeloproliferative neoplasm. The del(7q) emerged in the accelerated phase of disease, which was preceded by a lag phase of almost three years with normalized peripheral blood cell counts. Our results reveal that the del(7q), independently of other lesions, acts as a leukemic driver in this patient and that the stable long-lasting normalization of peripheral blood cell values concealed pending transformation.",

author = "Herborg, {Laura Laine} and Line Nederby and Eigil Kjeldsen and Kirsten Gr{\o}nb{\ae}k and Peter Hokland and Hansen, {Camilla Maria Holm} and {Celik Hansen}, Marcus and Roug, {Anne Stidsholt}",

year = "2013",

doi = "10.1016/j.lrr.2013.06.001",

language = "English",

volume = "2",

pages = "51--53",

journal = "Leukemia Research Reports",

issn = "2213-0489",

publisher = "Elsevier",

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TY - JOUR

T1 - Kinetics of del(7 q) driven leukemogenesis in a patient with JAK2 V617F and TET2 mutated chronic myeloproliferative neoplasm

AU - Herborg, Laura Laine

AU - Nederby, Line

AU - Kjeldsen, Eigil

AU - Grønbæk, Kirsten

AU - Hokland, Peter

AU - Hansen, Camilla Maria Holm

AU - Celik Hansen, Marcus

AU - Roug, Anne Stidsholt

PY - 2013

Y1 - 2013

N2 - Chronic myeloid neoplasms have susceptibility to transform into acute myeloid leukemia due to attainment of additional molecular lesions. We here describe the kinetics of a del(7q) driven leukemogenesis in a patient with multiple TET2 mutations and JAK2 V617F mutated chronic myeloproliferative neoplasm. The del(7q) emerged in the accelerated phase of disease, which was preceded by a lag phase of almost three years with normalized peripheral blood cell counts. Our results reveal that the del(7q), independently of other lesions, acts as a leukemic driver in this patient and that the stable long-lasting normalization of peripheral blood cell values concealed pending transformation.

AB - Chronic myeloid neoplasms have susceptibility to transform into acute myeloid leukemia due to attainment of additional molecular lesions. We here describe the kinetics of a del(7q) driven leukemogenesis in a patient with multiple TET2 mutations and JAK2 V617F mutated chronic myeloproliferative neoplasm. The del(7q) emerged in the accelerated phase of disease, which was preceded by a lag phase of almost three years with normalized peripheral blood cell counts. Our results reveal that the del(7q), independently of other lesions, acts as a leukemic driver in this patient and that the stable long-lasting normalization of peripheral blood cell values concealed pending transformation.

U2 - 10.1016/j.lrr.2013.06.001

DO - 10.1016/j.lrr.2013.06.001

M3 - Journal article

C2 - 24371780

SN - 2213-0489

VL - 2

SP - 51

EP - 53

JO - Leukemia Research Reports

JF - Leukemia Research Reports

IS - 2

ER -

Kinetics of del(7 q) driven leukemogenesis in a patient with JAK2 V617F and TET2 mutated chronic myeloproliferative neoplasm

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