Kinetics of 5-aminosalicylic acid after jejunal instillation in man

O Haagen Nielsen; S Bondesen

doi:10.1111/j.1365-2125.1983.tb02254.x

Kinetics of 5-aminosalicylic acid after jejunal instillation in man

O Haagen Nielsen^*, S Bondesen

^*Corresponding author af dette arbejde

106 Citationer (Scopus)

Abstract

The human pharmacokinetics of 5-aminosalicylic acid (5-ASA), the active moiety of salazosulphapyridine (SASP), is only known from studies in which rapid absorption has been deliberately avoided. The present investigation demonstrates that pure 5-ASA is absorbed extremely quickly when given as an instillation in the proximal part of the small bowel, and acetylation follows immediately. The metabolite is excreted very rapidly by the liver in small amounts, while the major part is eliminated renally.

Originalsprog	Engelsk
Tidsskrift	British Journal of Clinical Pharmacology. Supplement
Vol/bind	16
Udgave nummer	6
Sider (fra-til)	738-40
Antal sider	3
ISSN	0306-5251
DOI	https://doi.org/10.1111/j.1365-2125.1983.tb02254.x
Status	Udgivet - dec. 1983
Udgivet eksternt	Ja

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10.1111/j.1365-2125.1983.tb02254.x

Citationsformater

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title = "Kinetics of 5-aminosalicylic acid after jejunal instillation in man",

abstract = "The human pharmacokinetics of 5-aminosalicylic acid (5-ASA), the active moiety of salazosulphapyridine (SASP), is only known from studies in which rapid absorption has been deliberately avoided. The present investigation demonstrates that pure 5-ASA is absorbed extremely quickly when given as an instillation in the proximal part of the small bowel, and acetylation follows immediately. The metabolite is excreted very rapidly by the liver in small amounts, while the major part is eliminated renally.",

keywords = "Acetylation, Adult, Aminosalicylic Acids/administration & dosage, Female, Humans, Intestinal Absorption, Jejunum/metabolism, Kinetics, Male, Mesalamine",

author = "{Haagen Nielsen}, O and S Bondesen",

year = "1983",

month = dec,

doi = "10.1111/j.1365-2125.1983.tb02254.x",

language = "English",

volume = "16",

pages = "738--40",

journal = "British Journal of Clinical Pharmacology, Supplement",

issn = "0264-3774",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - Kinetics of 5-aminosalicylic acid after jejunal instillation in man

AU - Haagen Nielsen, O

AU - Bondesen, S

PY - 1983/12

Y1 - 1983/12

N2 - The human pharmacokinetics of 5-aminosalicylic acid (5-ASA), the active moiety of salazosulphapyridine (SASP), is only known from studies in which rapid absorption has been deliberately avoided. The present investigation demonstrates that pure 5-ASA is absorbed extremely quickly when given as an instillation in the proximal part of the small bowel, and acetylation follows immediately. The metabolite is excreted very rapidly by the liver in small amounts, while the major part is eliminated renally.

AB - The human pharmacokinetics of 5-aminosalicylic acid (5-ASA), the active moiety of salazosulphapyridine (SASP), is only known from studies in which rapid absorption has been deliberately avoided. The present investigation demonstrates that pure 5-ASA is absorbed extremely quickly when given as an instillation in the proximal part of the small bowel, and acetylation follows immediately. The metabolite is excreted very rapidly by the liver in small amounts, while the major part is eliminated renally.

KW - Acetylation

KW - Adult

KW - Aminosalicylic Acids/administration & dosage

KW - Female

KW - Humans

KW - Intestinal Absorption

KW - Jejunum/metabolism

KW - Kinetics

KW - Male

KW - Mesalamine

U2 - 10.1111/j.1365-2125.1983.tb02254.x

DO - 10.1111/j.1365-2125.1983.tb02254.x

M3 - Journal article

C2 - 6661362

SN - 0264-3774

VL - 16

SP - 738

EP - 740

JO - British Journal of Clinical Pharmacology, Supplement

JF - British Journal of Clinical Pharmacology, Supplement

IS - 6

ER -

Kinetics of 5-aminosalicylic acid after jejunal instillation in man

Abstract

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