TY - JOUR
T1 - Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool.
AU - Sitnicka, Ewa
AU - Bryder, David
AU - Theilgaard-Mönch, Kim
AU - Buza-Vidas, Natalija
AU - Adolfsson, Jörgen
AU - Jacobsen, Sten Eirik W
N1 - Keywords: Animals; Hematopoietic Stem Cells; Ligands; Lymphopoiesis; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelopoiesis; Phenotype; Recombinant Proteins; Stem Cell Factor
PY - 2002
Y1 - 2002
N2 - The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regulator of this process, in that adult mice deficient in expression of the flt3 ligand (FL) have severely (10-fold) reduced levels of the CLP, accompanied by reductions in the earliest identifiable B and T cell progenitors. In contrast, CMP and HSC are unaffected in FL-deficient mice. Noteworthy, CLP express high levels of both the flt3 receptor and ligand, indicating a potential autocrine role of FL in regulation of the earliest lymphoid commitment step from HSC.
AB - The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regulator of this process, in that adult mice deficient in expression of the flt3 ligand (FL) have severely (10-fold) reduced levels of the CLP, accompanied by reductions in the earliest identifiable B and T cell progenitors. In contrast, CMP and HSC are unaffected in FL-deficient mice. Noteworthy, CLP express high levels of both the flt3 receptor and ligand, indicating a potential autocrine role of FL in regulation of the earliest lymphoid commitment step from HSC.
M3 - Journal article
C2 - 12387740
SN - 1074-7613
VL - 17
SP - 463
EP - 472
JO - Immunity
JF - Immunity
IS - 4
ER -