JAFA: a protein function annotation meta-server.

TY - JOUR

T1 - JAFA: a protein function annotation meta-server.

AU - Friedberg, Iddo

AU - Harder, Tim

AU - Godzik, Adam

N1 - Keywords: Internet; Proteins; Sequence Analysis, Protein; Software; Systems Integration; User-Computer Interface; Vocabulary, Controlled

PY - 2006

Y1 - 2006

N2 - With the high number of sequences and structures streaming in from genomic projects, there is a need for more powerful and sophisticated annotation tools. Most problematic of the annotation efforts is predicting gene and protein function. Over the past few years there has been considerable progress in automated protein function prediction, using a diverse set of methods. Nevertheless, no single method reports all the information possible, and molecular biologists resort to 'shopping around' using different methods: a cumbersome and time-consuming practice. Here we present the Joined Assembly of Function Annotations, or JAFA server. JAFA queries several function prediction servers with a protein sequence and assembles the returned predictions in a legible, non-redundant format. In this manner, JAFA combines the predictions of several servers to provide a comprehensive view of what are the predicted functions of the proteins. JAFA also offers its own output, and the individual programs' predictions for further processing. JAFA is available for use from http://jafa.burnham.org.

AB - With the high number of sequences and structures streaming in from genomic projects, there is a need for more powerful and sophisticated annotation tools. Most problematic of the annotation efforts is predicting gene and protein function. Over the past few years there has been considerable progress in automated protein function prediction, using a diverse set of methods. Nevertheless, no single method reports all the information possible, and molecular biologists resort to 'shopping around' using different methods: a cumbersome and time-consuming practice. Here we present the Joined Assembly of Function Annotations, or JAFA server. JAFA queries several function prediction servers with a protein sequence and assembles the returned predictions in a legible, non-redundant format. In this manner, JAFA combines the predictions of several servers to provide a comprehensive view of what are the predicted functions of the proteins. JAFA also offers its own output, and the individual programs' predictions for further processing. JAFA is available for use from http://jafa.burnham.org.

U2 - 10.1093/nar/gkl045

DO - 10.1093/nar/gkl045

M3 - Journal article

C2 - 16845030

SN - 0305-1048

VL - 34

SP - W379-81

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - Web Server issue

ER -