Staphylococcus aureus coagulases are exploitable yet stable public goods in clinically relevant conditions

Urvish Trivedi; Jonas Stenløkke Madsen; Jake Everett; Cody Fell; Jakob Russel; Jakob Haaber; Heidi A. Crosby; Alexander R. Horswill; Mette Burmølle; Kendra P. Rumbaugh; Søren Johannes Sørensen

doi:10.1073/pnas.1804850115

Staphylococcus aureus coagulases are exploitable yet stable public goods in clinically relevant conditions

Urvish Trivedi, Jonas Stenløkke Madsen, Jake Everett, Cody Fell, Jakob Russel, Jakob Haaber, Heidi A. Crosby, Alexander R. Horswill, Mette Burmølle, Kendra P. Rumbaugh, Søren Johannes Sørensen

4 Citationer (Scopus)

Abstract

Coagulation is an innate defense mechanism intended to limit blood loss and trap invading pathogens during infection. However, Staphylococcus aureus has the ability to hijack the coagulation cascade and generate clots via secretion of coagulases. Although many S. aureus have this characteristic, some do not. The population dynamics regarding this defining trait have yet to be explored. We report here that coagulases are public goods that confer protection against antimicrobials and immune factors within a local population or community, thus promoting growth and virulence. By utilizing variants of a methicillin-resistant S. aureus we infer that the secretion of coagulases is a cooperative trait, which is subject to exploitation by invading mutants that do not produce the public goods themselves. However, overexploitation, "tragedy of the commons," does not occur at clinically relevant conditions. Our micrographs indicate this is due to spatial segregation and population viscosity. These findings emphasize the critical role of coagulases in a social evolution context and provide a possible explanation as to why the secretion of these public goods is maintained in mixed S. aureus communities.

Originalsprog	Engelsk
Tidsskrift	Proceedings of the National Academy of Sciences of the United States of America
Vol/bind	115
Udgave nummer	50
Sider (fra-til)	E11771-E11779
ISSN	0027-8424
DOI	https://doi.org/10.1073/pnas.1804850115
Status	Udgivet - 11 dec. 2018

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10.1073/pnas.1804850115

E11771.full.pdfForlagets udgivne version, 1,13 MB

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294911/Licens: Andet

Citationsformater

Trivedi, U., Madsen, J. S., Everett, J., Fell, C., Russel, J., Haaber, J., Crosby, H. A., Horswill, A. R., Burmølle, M., Rumbaugh, K. P., & Sørensen, S. J. (2018). Staphylococcus aureus coagulases are exploitable yet stable public goods in clinically relevant conditions. Proceedings of the National Academy of Sciences of the United States of America, 115(50), E11771-E11779. https://doi.org/10.1073/pnas.1804850115

Staphylococcus aureus coagulases are exploitable yet stable public goods in clinically relevant conditions. / Trivedi, Urvish ; Madsen, Jonas Stenløkke; Everett, Jake et al.
I: Proceedings of the National Academy of Sciences of the United States of America, Bind 115, Nr. 50, 11.12.2018, s. E11771-E11779.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Trivedi, U , Madsen, JS, Everett, J, Fell, C, Russel, J, Haaber, J, Crosby, HA, Horswill, AR, Burmølle, M, Rumbaugh, KP & Sørensen, SJ 2018, 'Staphylococcus aureus coagulases are exploitable yet stable public goods in clinically relevant conditions', Proceedings of the National Academy of Sciences of the United States of America, bind 115, nr. 50, s. E11771-E11779. https://doi.org/10.1073/pnas.1804850115

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title = "Staphylococcus aureus coagulases are exploitable yet stable public goods in clinically relevant conditions",

abstract = "Coagulation is an innate defense mechanism intended to limit blood loss and trap invading pathogens during infection. However, Staphylococcus aureus has the ability to hijack the coagulation cascade and generate clots via secretion of coagulases. Although many S. aureus have this characteristic, some do not. The population dynamics regarding this defining trait have yet to be explored. We report here that coagulases are public goods that confer protection against antimicrobials and immune factors within a local population or community, thus promoting growth and virulence. By utilizing variants of a methicillin-resistant S. aureus we infer that the secretion of coagulases is a cooperative trait, which is subject to exploitation by invading mutants that do not produce the public goods themselves. However, overexploitation, {"}tragedy of the commons,{"} does not occur at clinically relevant conditions. Our micrographs indicate this is due to spatial segregation and population viscosity. These findings emphasize the critical role of coagulases in a social evolution context and provide a possible explanation as to why the secretion of these public goods is maintained in mixed S. aureus communities.",

author = "Urvish Trivedi and Madsen, {Jonas Stenl{\o}kke} and Jake Everett and Cody Fell and Jakob Russel and Jakob Haaber and Crosby, {Heidi A.} and Horswill, {Alexander R.} and Mette Burm{\o}lle and Rumbaugh, {Kendra P.} and S{\o}rensen, {S{\o}ren Johannes}",

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AU - Trivedi, Urvish

AU - Madsen, Jonas Stenløkke

AU - Everett, Jake

AU - Fell, Cody

AU - Russel, Jakob

AU - Haaber, Jakob

AU - Crosby, Heidi A.

AU - Horswill, Alexander R.

AU - Burmølle, Mette

AU - Rumbaugh, Kendra P.

AU - Sørensen, Søren Johannes

PY - 2018/12/11

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N2 - Coagulation is an innate defense mechanism intended to limit blood loss and trap invading pathogens during infection. However, Staphylococcus aureus has the ability to hijack the coagulation cascade and generate clots via secretion of coagulases. Although many S. aureus have this characteristic, some do not. The population dynamics regarding this defining trait have yet to be explored. We report here that coagulases are public goods that confer protection against antimicrobials and immune factors within a local population or community, thus promoting growth and virulence. By utilizing variants of a methicillin-resistant S. aureus we infer that the secretion of coagulases is a cooperative trait, which is subject to exploitation by invading mutants that do not produce the public goods themselves. However, overexploitation, "tragedy of the commons," does not occur at clinically relevant conditions. Our micrographs indicate this is due to spatial segregation and population viscosity. These findings emphasize the critical role of coagulases in a social evolution context and provide a possible explanation as to why the secretion of these public goods is maintained in mixed S. aureus communities.

AB - Coagulation is an innate defense mechanism intended to limit blood loss and trap invading pathogens during infection. However, Staphylococcus aureus has the ability to hijack the coagulation cascade and generate clots via secretion of coagulases. Although many S. aureus have this characteristic, some do not. The population dynamics regarding this defining trait have yet to be explored. We report here that coagulases are public goods that confer protection against antimicrobials and immune factors within a local population or community, thus promoting growth and virulence. By utilizing variants of a methicillin-resistant S. aureus we infer that the secretion of coagulases is a cooperative trait, which is subject to exploitation by invading mutants that do not produce the public goods themselves. However, overexploitation, "tragedy of the commons," does not occur at clinically relevant conditions. Our micrographs indicate this is due to spatial segregation and population viscosity. These findings emphasize the critical role of coagulases in a social evolution context and provide a possible explanation as to why the secretion of these public goods is maintained in mixed S. aureus communities.

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DO - 10.1073/pnas.1804850115

M3 - Journal article

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SN - 0027-8424

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JF - Proceedings of the National Academy of Sciences of the United States of America

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Staphylococcus aureus coagulases are exploitable yet stable public goods in clinically relevant conditions

Abstract

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