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Is oral absorption of vigabatrin carrier-mediated?
M. K. Nøhr, R. V. Juul, Z. I. Thale, R. Holm, M. Kreilgaard
*
, Carsten Uhd Nielsen
*
Corresponding author af dette arbejde
8
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Keyphrases
Carrier-mediated
100%
Oral Absorption
100%
Vigabatrin
100%
Proton-coupled Amino Acid Transporter
60%
Michaelis Constant
30%
Proline
10%
Population Pharmacokinetic Model
10%
Absorption Mechanism
10%
Intestinal Transport
10%
Pharmacokinetics
10%
Sarcosine
10%
Low Affinity
10%
Absorption Rate
10%
Vmax
10%
High Capacity
10%
Mechanistic Model
10%
Transport Mechanism
10%
Pharmacokinetic Model
10%
Pharmacokinetic Profile
10%
Modeling Approach
10%
Tryptophan
10%
Dose Effect
10%
Pharmacokinetic Parameters
10%
Nonlinear Mixed Effects
10%
Sprague-Dawley Rats
10%
Biochemistry, Genetics and Molecular Biology
Amino Acid Transporter
100%
Absorption
83%
Pharmacokinetic
83%
Michaelis Constant
50%
Maximum Reaction Velocity
16%
Intestine Absorption
16%
Proline
16%
Tryptophan
16%
Sarcosine
16%
Sprague Dawley Rat
16%
Pharmacology, Toxicology and Pharmaceutical Science
Vigabatrin
100%
Amino Acid Transporter
60%
Pharmacokinetic
40%
Bioavailability
20%
Sprague Dawley Rat
10%
Proline
10%
Pharmacokinetic Parameter
10%
Sarcosine
10%
Tryptophan
10%