Is going into stable symptomatic remission associated with a more positive development of life satisfaction?: A 10-year follow-up study of first episode psychosis

Erlend Strand Gardsjord; Kristin Lie Romm; Jan Ivar Røssberg; Svein Friis; Helene Eidsmo Barder; Julie Evensen; Ulrik Haahr; Wenche Ten Velden Hegelstad; Inge Joa; Jan Olav Johannessen; Johannes Langeveld; Tor Ketil Larsen; Stein Opjordsmoen; Bjørn Rishovd Rund; Erik Simonsen; Per Vaglum; Thomas McGlashan; Ingrid Melle

doi:10.1016/j.schres.2017.07.006

Is going into stable symptomatic remission associated with a more positive development of life satisfaction? A 10-year follow-up study of first episode psychosis

Erlend Strand Gardsjord, Kristin Lie Romm, Jan Ivar Røssberg, Svein Friis, Helene Eidsmo Barder, Julie Evensen, Ulrik Haahr, Wenche Ten Velden Hegelstad, Inge Joa, Jan Olav Johannessen, Johannes Langeveld, Tor Ketil Larsen, Stein Opjordsmoen, Bjørn Rishovd Rund, Erik Simonsen, Per Vaglum, Thomas McGlashan, Ingrid Melle

Institut for Klinisk Medicin

4 Citationer (Scopus)

Abstract

BACKGROUND: Quality of life is an important outcome measure for patients with psychosis. We investigated whether going into stable symptomatic remission is associated with a more positive development of subjective quality of life (S-QoL) and if different patient characteristics are associated with S-QoL depending on remission status.

METHODS: Three hundred and one patients with a first-episode psychosis were included at baseline. At 10-year follow-up 186 were reassessed. QoL was assessed by Lehman's Quality of Life Interview. Remission was defined according to criteria proposed by the Remission in Schizophrenia Working Group. One-way ANOVA, mixed model analysis, bivariate correlations and multiple regression analyses were performed.

RESULTS: Patients going into stable symptomatic remission showed a more positive S-QoL-development over the follow-up period and reported higher life satisfaction at 10-year follow-up compared to non-remission. At 10-year follow-up, depressive symptoms and alcohol abuse or dependence explained a significant amount of variance in S-QoL among patients in remission. Among patients in non-remission, PANSS excitative component explained a significant amount of variance in S-QoL. All significant effects were negative.

CONCLUSIONS: Stable symptomatic remission is associated with a more positive development of overall life satisfaction. Furthermore, different symptoms influence life satisfaction depending on status of remission. This has important clinical implications. While patients in remission might need treatment for depressive symptoms to increase S-QoL, in non-remission measures aiming to decrease hostility and uncooperativeness should be part of the treatment approach. Alcohol problems should be treated regardless of remission status.

Originalsprog	Engelsk
Tidsskrift	Schizophrenia Research
Vol/bind	193
Sider (fra-til)	364-369
ISSN	0920-9964
DOI	https://doi.org/10.1016/j.schres.2017.07.006
Status	Udgivet - mar. 2018

Adgang til dokumentet

10.1016/j.schres.2017.07.006

Citationsformater

Gardsjord, E. S., Romm, K. L., Røssberg, J. I., Friis, S., Barder, H. E., Evensen, J., Haahr, U., Ten Velden Hegelstad, W., Joa, I., Johannessen, J. O., Langeveld, J., Larsen, T. K., Opjordsmoen, S., Rund, B. R., Simonsen, E., Vaglum, P., McGlashan, T., & Melle, I. (2018). Is going into stable symptomatic remission associated with a more positive development of life satisfaction? A 10-year follow-up study of first episode psychosis. Schizophrenia Research, 193, 364-369. https://doi.org/10.1016/j.schres.2017.07.006

Is going into stable symptomatic remission associated with a more positive development of life satisfaction? A 10-year follow-up study of first episode psychosis. / Gardsjord, Erlend Strand; Romm, Kristin Lie; Røssberg, Jan Ivar et al.
I: Schizophrenia Research, Bind 193, 03.2018, s. 364-369.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Gardsjord, ES, Romm, KL, Røssberg, JI, Friis, S, Barder, HE, Evensen, J, Haahr, U, Ten Velden Hegelstad, W, Joa, I, Johannessen, JO, Langeveld, J, Larsen, TK, Opjordsmoen, S, Rund, BR, Simonsen, E, Vaglum, P, McGlashan, T & Melle, I 2018, 'Is going into stable symptomatic remission associated with a more positive development of life satisfaction? A 10-year follow-up study of first episode psychosis', Schizophrenia Research, bind 193, s. 364-369. https://doi.org/10.1016/j.schres.2017.07.006

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title = "Is going into stable symptomatic remission associated with a more positive development of life satisfaction?: A 10-year follow-up study of first episode psychosis",

abstract = "BACKGROUND: Quality of life is an important outcome measure for patients with psychosis. We investigated whether going into stable symptomatic remission is associated with a more positive development of subjective quality of life (S-QoL) and if different patient characteristics are associated with S-QoL depending on remission status.METHODS: Three hundred and one patients with a first-episode psychosis were included at baseline. At 10-year follow-up 186 were reassessed. QoL was assessed by Lehman's Quality of Life Interview. Remission was defined according to criteria proposed by the Remission in Schizophrenia Working Group. One-way ANOVA, mixed model analysis, bivariate correlations and multiple regression analyses were performed.RESULTS: Patients going into stable symptomatic remission showed a more positive S-QoL-development over the follow-up period and reported higher life satisfaction at 10-year follow-up compared to non-remission. At 10-year follow-up, depressive symptoms and alcohol abuse or dependence explained a significant amount of variance in S-QoL among patients in remission. Among patients in non-remission, PANSS excitative component explained a significant amount of variance in S-QoL. All significant effects were negative.CONCLUSIONS: Stable symptomatic remission is associated with a more positive development of overall life satisfaction. Furthermore, different symptoms influence life satisfaction depending on status of remission. This has important clinical implications. While patients in remission might need treatment for depressive symptoms to increase S-QoL, in non-remission measures aiming to decrease hostility and uncooperativeness should be part of the treatment approach. Alcohol problems should be treated regardless of remission status.",

keywords = "Journal Article",

author = "Gardsjord, {Erlend Strand} and Romm, {Kristin Lie} and R{\o}ssberg, {Jan Ivar} and Svein Friis and Barder, {Helene Eidsmo} and Julie Evensen and Ulrik Haahr and {Ten Velden Hegelstad}, Wenche and Inge Joa and Johannessen, {Jan Olav} and Johannes Langeveld and Larsen, {Tor Ketil} and Stein Opjordsmoen and Rund, {Bj{\o}rn Rishovd} and Erik Simonsen and Per Vaglum and Thomas McGlashan and Ingrid Melle",

note = "Copyright {\textcopyright} 2017. Published by Elsevier B.V.",

year = "2018",

month = mar,

doi = "10.1016/j.schres.2017.07.006",

language = "English",

volume = "193",

pages = "364--369",

journal = "Schizophrenia Research",

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TY - JOUR

T1 - Is going into stable symptomatic remission associated with a more positive development of life satisfaction?

T2 - A 10-year follow-up study of first episode psychosis

AU - Gardsjord, Erlend Strand

AU - Romm, Kristin Lie

AU - Røssberg, Jan Ivar

AU - Friis, Svein

AU - Barder, Helene Eidsmo

AU - Evensen, Julie

AU - Haahr, Ulrik

AU - Ten Velden Hegelstad, Wenche

AU - Joa, Inge

AU - Johannessen, Jan Olav

AU - Langeveld, Johannes

AU - Larsen, Tor Ketil

AU - Opjordsmoen, Stein

AU - Rund, Bjørn Rishovd

AU - Simonsen, Erik

AU - Vaglum, Per

AU - McGlashan, Thomas

AU - Melle, Ingrid

PY - 2018/3

Y1 - 2018/3

N2 - BACKGROUND: Quality of life is an important outcome measure for patients with psychosis. We investigated whether going into stable symptomatic remission is associated with a more positive development of subjective quality of life (S-QoL) and if different patient characteristics are associated with S-QoL depending on remission status.METHODS: Three hundred and one patients with a first-episode psychosis were included at baseline. At 10-year follow-up 186 were reassessed. QoL was assessed by Lehman's Quality of Life Interview. Remission was defined according to criteria proposed by the Remission in Schizophrenia Working Group. One-way ANOVA, mixed model analysis, bivariate correlations and multiple regression analyses were performed.RESULTS: Patients going into stable symptomatic remission showed a more positive S-QoL-development over the follow-up period and reported higher life satisfaction at 10-year follow-up compared to non-remission. At 10-year follow-up, depressive symptoms and alcohol abuse or dependence explained a significant amount of variance in S-QoL among patients in remission. Among patients in non-remission, PANSS excitative component explained a significant amount of variance in S-QoL. All significant effects were negative.CONCLUSIONS: Stable symptomatic remission is associated with a more positive development of overall life satisfaction. Furthermore, different symptoms influence life satisfaction depending on status of remission. This has important clinical implications. While patients in remission might need treatment for depressive symptoms to increase S-QoL, in non-remission measures aiming to decrease hostility and uncooperativeness should be part of the treatment approach. Alcohol problems should be treated regardless of remission status.

AB - BACKGROUND: Quality of life is an important outcome measure for patients with psychosis. We investigated whether going into stable symptomatic remission is associated with a more positive development of subjective quality of life (S-QoL) and if different patient characteristics are associated with S-QoL depending on remission status.METHODS: Three hundred and one patients with a first-episode psychosis were included at baseline. At 10-year follow-up 186 were reassessed. QoL was assessed by Lehman's Quality of Life Interview. Remission was defined according to criteria proposed by the Remission in Schizophrenia Working Group. One-way ANOVA, mixed model analysis, bivariate correlations and multiple regression analyses were performed.RESULTS: Patients going into stable symptomatic remission showed a more positive S-QoL-development over the follow-up period and reported higher life satisfaction at 10-year follow-up compared to non-remission. At 10-year follow-up, depressive symptoms and alcohol abuse or dependence explained a significant amount of variance in S-QoL among patients in remission. Among patients in non-remission, PANSS excitative component explained a significant amount of variance in S-QoL. All significant effects were negative.CONCLUSIONS: Stable symptomatic remission is associated with a more positive development of overall life satisfaction. Furthermore, different symptoms influence life satisfaction depending on status of remission. This has important clinical implications. While patients in remission might need treatment for depressive symptoms to increase S-QoL, in non-remission measures aiming to decrease hostility and uncooperativeness should be part of the treatment approach. Alcohol problems should be treated regardless of remission status.

KW - Journal Article

U2 - 10.1016/j.schres.2017.07.006

DO - 10.1016/j.schres.2017.07.006

M3 - Journal article

C2 - 28701275

SN - 0920-9964

VL - 193

SP - 364

EP - 369

JO - Schizophrenia Research

JF - Schizophrenia Research

ER -

Is going into stable symptomatic remission associated with a more positive development of life satisfaction? A 10-year follow-up study of first episode psychosis

Abstract

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