Is DAS28-CRP with three and four variables interchangeable in individual patients selected for biological treatment in daily clinical practice?

TY - JOUR

T1 - Is DAS28-CRP with three and four variables interchangeable in individual patients selected for biological treatment in daily clinical practice?

AU - Madsen, Ole Rintek

PY - 2011/12

Y1 - 2011/12

N2 - DAS28 is a widely used composite score for the assessment of disease activity in patients with rheumatoid arthritis (RA) and is often used as a treatment decision tool in the daily clinic. Different versions of DAS28 are available. DAS28-CRP(3) is calculated based on three variables: swollen and tender joint counts and CRP. DAS28-CRP(4) also includes patient global assessment. Thresholds for low and high disease activity are the same for the two scores. Based on the Bland-Altman method, the interchangeability between DAS28-CRP with three and four variables was examined in 319 RA patients selected for initiating biological treatment. Data were extracted from the Danish registry for biological treatment in rheumatology (DANBIO). Multiple regression analysis was used to assess the predictability of the DAS28 scores by several measures of disease activity. The overall mean DAS28-CRP was 4.7¿±¿1.2. The mean difference between the two scores (the bias) was -0.29¿±¿0.33 (CI -0.33, -0.25) (p¿

AB - DAS28 is a widely used composite score for the assessment of disease activity in patients with rheumatoid arthritis (RA) and is often used as a treatment decision tool in the daily clinic. Different versions of DAS28 are available. DAS28-CRP(3) is calculated based on three variables: swollen and tender joint counts and CRP. DAS28-CRP(4) also includes patient global assessment. Thresholds for low and high disease activity are the same for the two scores. Based on the Bland-Altman method, the interchangeability between DAS28-CRP with three and four variables was examined in 319 RA patients selected for initiating biological treatment. Data were extracted from the Danish registry for biological treatment in rheumatology (DANBIO). Multiple regression analysis was used to assess the predictability of the DAS28 scores by several measures of disease activity. The overall mean DAS28-CRP was 4.7¿±¿1.2. The mean difference between the two scores (the bias) was -0.29¿±¿0.33 (CI -0.33, -0.25) (p¿

U2 - 10.1007/s10067-011-1847-6

DO - 10.1007/s10067-011-1847-6

M3 - Journal article

SN - 0770-3198

VL - 30

SP - 1577

EP - 1582

JO - Clinical Rheumatology

JF - Clinical Rheumatology

IS - 12

ER -