TY - JOUR
T1 - Irregular Firing and High-Conductance States in Spinal Motoneurons during Scratching and Swimming
AU - Guzulaitis, Robertas
AU - Hounsgaard, Jorn
AU - Alaburda, Aidas
N1 - Copyright © 2016 the authors 0270-6474/16/365799-09$15.00/0.
PY - 2016/5/25
Y1 - 2016/5/25
N2 - Intense synaptic transmission during scratch network activity increases conductance and induces irregular firing in spinal motoneurons. It is not known whether this high-conductance state is a select feature for scratching or a property that goes with spinal motor network activity in general. Here we compare conductance and firing patterns in spinal motoneurons during network activity for scratching and swimming in an ex vivo carapace-spinal cord preparation from adult turtles (Trachemys scripta elegans). The pattern and relative engagement of motoneurons are distinctly different in scratching and swimming. Nevertheless, we found increased synaptic fluctuations in membrane potential, irregular firing, and increased conductance in spinal motoneurons during scratch and swim network activity. Our finding indicates that intense synaptic activation of motoneurons is a general feature of spinal motor network activity.
AB - Intense synaptic transmission during scratch network activity increases conductance and induces irregular firing in spinal motoneurons. It is not known whether this high-conductance state is a select feature for scratching or a property that goes with spinal motor network activity in general. Here we compare conductance and firing patterns in spinal motoneurons during network activity for scratching and swimming in an ex vivo carapace-spinal cord preparation from adult turtles (Trachemys scripta elegans). The pattern and relative engagement of motoneurons are distinctly different in scratching and swimming. Nevertheless, we found increased synaptic fluctuations in membrane potential, irregular firing, and increased conductance in spinal motoneurons during scratch and swim network activity. Our finding indicates that intense synaptic activation of motoneurons is a general feature of spinal motor network activity.
U2 - 10.1523/jneurosci.0320-16.2016
DO - 10.1523/jneurosci.0320-16.2016
M3 - Journal article
C2 - 27225769
SN - 0270-6474
VL - 36
SP - 5799
EP - 5807
JO - The Journal of neuroscience : the official journal of the Society for Neuroscience
JF - The Journal of neuroscience : the official journal of the Society for Neuroscience
IS - 21
ER -