Iron inhibits respiratory burst of peritoneal phagocytes in vitro

TY - JOUR

T1 - Iron inhibits respiratory burst of peritoneal phagocytes in vitro

AU - Gotfryd, Kamil

AU - Jurek, Aleksandra

AU - Kubit, Piotr

AU - Klein, Andrzej

AU - Turyna, Bohdan

PY - 2011

Y1 - 2011

N2 - Objective. This study examines the effects of iron ions Fe(3+) on the respiratory burst of phagocytes isolated from peritoneal effluents of continuous ambulatory peritoneal dialysis (CAPD) patients, as an in vitro model of iron overload in end-stage renal disease (ESRD). Material and Methods. Respiratory burst of peritoneal phagocytes was measured by chemiluminescence method. Results. At the highest used concentration of iron ions Fe(3+) (100 µM), free radicals production by peritoneal phagocytes was reduced by 90% compared to control. Conclusions. Iron overload may increase the risk of infectious complications in ESRD patients.

AB - Objective. This study examines the effects of iron ions Fe(3+) on the respiratory burst of phagocytes isolated from peritoneal effluents of continuous ambulatory peritoneal dialysis (CAPD) patients, as an in vitro model of iron overload in end-stage renal disease (ESRD). Material and Methods. Respiratory burst of peritoneal phagocytes was measured by chemiluminescence method. Results. At the highest used concentration of iron ions Fe(3+) (100 µM), free radicals production by peritoneal phagocytes was reduced by 90% compared to control. Conclusions. Iron overload may increase the risk of infectious complications in ESRD patients.

U2 - 10.5402/2011/605436

DO - 10.5402/2011/605436

M3 - Journal article

C2 - 22203913

SN - 2090-4452

VL - 2011

SP - 1

EP - 5

JO - International Scholarly Research Notices

JF - International Scholarly Research Notices

IS - 605436

ER -