TY - JOUR
T1 - Pseudomonas aeruginosa Biofilm Infections
T2 - Community Structure, Antimicrobial Tolerance and Immune Response
AU - Rybtke, Morten
AU - Hultqvist, Louise Dahl
AU - Givskov, Michael
AU - Tolker-Nielsen, Tim
N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.
PY - 2015/11/20
Y1 - 2015/11/20
N2 - Studies of biopsies from infectious sites, explanted tissue and medical devises have provided evidence that biofilms are the underlying cause of a variety of tissue-associated and implant-associated recalcitrant human infections. With a need for novel anti-biofilm treatment strategies, research in biofilm infection microbiology, biofilm formation mechanisms and biofilm-associated antimicrobial tolerance has become an important area in microbiology. Substantial knowledge about biofilm formation mechanisms, biofilm-associated antimicrobial tolerance and immune evasion mechanisms has been obtained through work with biofilms grown in in vitro experimental setups, and the relevance of this information in the context of chronic infections is being investigated by the use of animal models of infection. Because our current in vitro experimental setups and animal models have limitations, new advanced in vitro models developed with knowledge about the chemical landscape at infectious sites are needed.
AB - Studies of biopsies from infectious sites, explanted tissue and medical devises have provided evidence that biofilms are the underlying cause of a variety of tissue-associated and implant-associated recalcitrant human infections. With a need for novel anti-biofilm treatment strategies, research in biofilm infection microbiology, biofilm formation mechanisms and biofilm-associated antimicrobial tolerance has become an important area in microbiology. Substantial knowledge about biofilm formation mechanisms, biofilm-associated antimicrobial tolerance and immune evasion mechanisms has been obtained through work with biofilms grown in in vitro experimental setups, and the relevance of this information in the context of chronic infections is being investigated by the use of animal models of infection. Because our current in vitro experimental setups and animal models have limitations, new advanced in vitro models developed with knowledge about the chemical landscape at infectious sites are needed.
U2 - 10.1016/j.jmb.2015.08.016
DO - 10.1016/j.jmb.2015.08.016
M3 - Review
C2 - 26319792
SN - 0022-2836
VL - 427
SP - 3628
EP - 3645
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
IS - 23
ER -