Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis

Eske M Derks; Jacob A S Vorstman; Stephan Ripke; Rene S Kahn; Roel A Ophoff; Schizophrenia Psychiatric Genomic Consortium; Thomas Hansen; Line Olsen; Klaus Damgaard Jakobsen; Henriette Schmock; Celina Skjødt; Anders Rosengren; Louise.K.Enggaard Høffding; Johan Hilge Thygesen; Thomas Mears Werge

doi:10.1371/journal.pone.0037852

Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis

Eske M Derks, Jacob A S Vorstman, Stephan Ripke, Rene S Kahn, Roel A Ophoff, Schizophrenia Psychiatric Genomic Consortium, Thomas Hansen, Line Olsen, Klaus Damgaard Jakobsen, Henriette Schmock, Celina Skjødt, Anders Rosengren, Louise.K.Enggaard Høffding, Johan Hilge Thygesen, Thomas Mears Werge

50 Citationer (Scopus)

Abstract

The presence of subclinical levels of psychosis in the general population may imply that schizophrenia is the extreme expression of more or less continuously distributed traits in the population. In a previous study, we identified five quantitative measures of schizophrenia (positive, negative, disorganisation, mania, and depression scores). The aim of this study is to examine the association between a direct measure of genetic risk of schizophrenia and the five quantitative measures of psychosis. Estimates of the log of the odds ratios of case/control allelic association tests were obtained from the Psychiatric GWAS Consortium (PGC) (minus our sample) which included genome-wide genotype data of 8,690 schizophrenia cases and 11,831 controls. These data were used to calculate genetic risk scores in 314 schizophrenia cases and 148 controls from the Netherlands for whom genotype data and quantitative symptom scores were available. The genetic risk score of schizophrenia was significantly associated with case-control status (p

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	7
Udgave nummer	6
Sider (fra-til)	e37852
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0037852
Status	Udgivet - 22 jun. 2012

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10.1371/journal.pone.0037852

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Derks, E. M., Vorstman, J. A. S., Ripke, S., Kahn, R. S., Ophoff, R. A., Schizophrenia Psychiatric Genomic Consortium, Hansen, T., Olsen, L., Jakobsen, K. D., Schmock, H., Skjødt, C., Rosengren, A., Høffding, L. K. E., Thygesen, J. H., & Werge, T. M. (2012). Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis. P L o S One, 7(6), e37852. https://doi.org/10.1371/journal.pone.0037852

Derks, EM, Vorstman, JAS, Ripke, S, Kahn, RS, Ophoff, RA, Schizophrenia Psychiatric Genomic Consortium, Hansen, T, Olsen, L, Jakobsen, KD, Schmock, H, Skjødt, C, Rosengren, A, Høffding, LKE, Thygesen, JH & Werge, TM 2012, 'Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis', P L o S One, bind 7, nr. 6, s. e37852. https://doi.org/10.1371/journal.pone.0037852

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abstract = "The presence of subclinical levels of psychosis in the general population may imply that schizophrenia is the extreme expression of more or less continuously distributed traits in the population. In a previous study, we identified five quantitative measures of schizophrenia (positive, negative, disorganisation, mania, and depression scores). The aim of this study is to examine the association between a direct measure of genetic risk of schizophrenia and the five quantitative measures of psychosis. Estimates of the log of the odds ratios of case/control allelic association tests were obtained from the Psychiatric GWAS Consortium (PGC) (minus our sample) which included genome-wide genotype data of 8,690 schizophrenia cases and 11,831 controls. These data were used to calculate genetic risk scores in 314 schizophrenia cases and 148 controls from the Netherlands for whom genotype data and quantitative symptom scores were available. The genetic risk score of schizophrenia was significantly associated with case-control status (p",

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AU - Derks, Eske M

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AU - Kahn, Rene S

AU - Ophoff, Roel A

AU - Schizophrenia Psychiatric Genomic Consortium

AU - Hansen, Thomas

AU - Olsen, Line

AU - Jakobsen, Klaus Damgaard

AU - Schmock, Henriette

AU - Skjødt, Celina

AU - Rosengren, Anders

AU - Høffding, Louise.K.Enggaard

AU - Thygesen, Johan Hilge

AU - Werge, Thomas Mears

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AB - The presence of subclinical levels of psychosis in the general population may imply that schizophrenia is the extreme expression of more or less continuously distributed traits in the population. In a previous study, we identified five quantitative measures of schizophrenia (positive, negative, disorganisation, mania, and depression scores). The aim of this study is to examine the association between a direct measure of genetic risk of schizophrenia and the five quantitative measures of psychosis. Estimates of the log of the odds ratios of case/control allelic association tests were obtained from the Psychiatric GWAS Consortium (PGC) (minus our sample) which included genome-wide genotype data of 8,690 schizophrenia cases and 11,831 controls. These data were used to calculate genetic risk scores in 314 schizophrenia cases and 148 controls from the Netherlands for whom genotype data and quantitative symptom scores were available. The genetic risk score of schizophrenia was significantly associated with case-control status (p

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Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis

Abstract

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