Investigating the causal effect of vitamin D on serum adiponectin using a mendelian randomization approach

L. L. N. Husemoen; T. Skaaby; Torben Martinussen; Torben Jørgensen; B. H. Thuesen; C. Kistorp; J. Jeppesen; J. P. Thyssen; M. Meldgaard; P. B. Szecsi; M. Fenger; A. Linneberg

doi:10.1038/ejcn.2013.233

Investigating the causal effect of vitamin D on serum adiponectin using a mendelian randomization approach

L. L. N. Husemoen^*, T. Skaaby, Torben Martinussen, Torben Jørgensen, B. H. Thuesen, C. Kistorp, J. Jeppesen, J. P. Thyssen, M. Meldgaard, P. B. Szecsi, M. Fenger, A. Linneberg

^*Corresponding author af dette arbejde

22 Citationer (Scopus)

Abstract

Background/Objectives: The aim was to examine the causal effect of vitamin D on serum adiponectin using a multiple instrument Mendelian randomization approach. Subjects/Methods: Serum 25-hydroxy vitamin D (25(OH)D) and serum total or high molecular weight (HMW) adiponectin were measured in two Danish population-based studies: the Inter99 study (6405 adults, 30-60 years) conducted in 1999-2001, and the MONICA10 study (2656 adults, 41-71 years) conducted in 1993-1994. Results: In the Inter99 study, serum 25(OH)D was positively associated with total adiponectin (the effect estimate in % per doubling of 25(OH)D was 4.78, 95% CI: 1.96, 7.68, P<0.001). Using variations in the vitamin D-binding protein gene and the filaggrin gene as instrumental variables, the causal effect in % was estimated to 61.46, 95% CI: 17.51, 120.28, P=0.003 higher adiponectin per doubling of 25(OH)D. In the MONICA10 cohort, no significant association was observed between the serum concentrations of 25(OH)D and HMW adiponectin (the effect estimate in % per doubling of 25(OH)D was-1.51, 95% CI:-5.80, 2.98, P=0.50), although the instrumental variables analysis to some extent supported a positive causal association (the effect estimate in % per doubling of 25(OH)D was 37.13, 95% CI:-3.67, 95.20, P=0.080). Conclusions: The results indicate a possible causal association between serum 25(OH)D and total adiponectin. However, the association was not replicated for HMW adiponectin. Thus, further studies are needed to confirm a causal relationship.

Originalsprog	Engelsk
Tidsskrift	European Journal of Clinical Nutrition
Vol/bind	68
Sider (fra-til)	189-195
Antal sider	7
ISSN	0954-3007
DOI	https://doi.org/10.1038/ejcn.2013.233
Status	Udgivet - 2014

Adgang til dokumentet

10.1038/ejcn.2013.233

https://www.nature.com/articles/ejcn2013233.pdf

Andre filer og links

Link to publication in Scopus

Citationsformater

Husemoen, L. L. N., Skaaby, T., Martinussen, T., Jørgensen, T., Thuesen, B. H., Kistorp, C., Jeppesen, J., Thyssen, J. P., Meldgaard, M., Szecsi, P. B., Fenger, M., & Linneberg, A. (2014). Investigating the causal effect of vitamin D on serum adiponectin using a mendelian randomization approach. European Journal of Clinical Nutrition, 68, 189-195. https://doi.org/10.1038/ejcn.2013.233

Husemoen, LLN, Skaaby, T, Martinussen, T, Jørgensen, T, Thuesen, BH, Kistorp, C, Jeppesen, J, Thyssen, JP, Meldgaard, M, Szecsi, PB, Fenger, M & Linneberg, A 2014, 'Investigating the causal effect of vitamin D on serum adiponectin using a mendelian randomization approach', European Journal of Clinical Nutrition, bind 68, s. 189-195. https://doi.org/10.1038/ejcn.2013.233

@article{fcf2a0b7bda346feba40e538698e6982,

title = "Investigating the causal effect of vitamin D on serum adiponectin using a mendelian randomization approach",

abstract = "Background/Objectives: The aim was to examine the causal effect of vitamin D on serum adiponectin using a multiple instrument Mendelian randomization approach. Subjects/Methods: Serum 25-hydroxy vitamin D (25(OH)D) and serum total or high molecular weight (HMW) adiponectin were measured in two Danish population-based studies: the Inter99 study (6405 adults, 30-60 years) conducted in 1999-2001, and the MONICA10 study (2656 adults, 41-71 years) conducted in 1993-1994. Results: In the Inter99 study, serum 25(OH)D was positively associated with total adiponectin (the effect estimate in % per doubling of 25(OH)D was 4.78, 95% CI: 1.96, 7.68, P<0.001). Using variations in the vitamin D-binding protein gene and the filaggrin gene as instrumental variables, the causal effect in % was estimated to 61.46, 95% CI: 17.51, 120.28, P=0.003 higher adiponectin per doubling of 25(OH)D. In the MONICA10 cohort, no significant association was observed between the serum concentrations of 25(OH)D and HMW adiponectin (the effect estimate in % per doubling of 25(OH)D was-1.51, 95% CI:-5.80, 2.98, P=0.50), although the instrumental variables analysis to some extent supported a positive causal association (the effect estimate in % per doubling of 25(OH)D was 37.13, 95% CI:-3.67, 95.20, P=0.080). Conclusions: The results indicate a possible causal association between serum 25(OH)D and total adiponectin. However, the association was not replicated for HMW adiponectin. Thus, further studies are needed to confirm a causal relationship.",

author = "Husemoen, {L. L. N.} and T. Skaaby and Torben Martinussen and Torben J{\o}rgensen and Thuesen, {B. H.} and C. Kistorp and J. Jeppesen and Thyssen, {J. P.} and M. Meldgaard and Szecsi, {P. B.} and M. Fenger and A. Linneberg",

year = "2014",

doi = "10.1038/ejcn.2013.233",

language = "English",

volume = "68",

pages = "189--195",

journal = "European Journal of Clinical Nutrition",

issn = "0954-3007",

publisher = "nature publishing group",

}

TY - JOUR

T1 - Investigating the causal effect of vitamin D on serum adiponectin using a mendelian randomization approach

AU - Husemoen, L. L. N.

AU - Skaaby, T.

AU - Martinussen, Torben

AU - Jørgensen, Torben

AU - Thuesen, B. H.

AU - Kistorp, C.

AU - Jeppesen, J.

AU - Thyssen, J. P.

AU - Meldgaard, M.

AU - Szecsi, P. B.

AU - Fenger, M.

AU - Linneberg, A.

PY - 2014

Y1 - 2014

N2 - Background/Objectives: The aim was to examine the causal effect of vitamin D on serum adiponectin using a multiple instrument Mendelian randomization approach. Subjects/Methods: Serum 25-hydroxy vitamin D (25(OH)D) and serum total or high molecular weight (HMW) adiponectin were measured in two Danish population-based studies: the Inter99 study (6405 adults, 30-60 years) conducted in 1999-2001, and the MONICA10 study (2656 adults, 41-71 years) conducted in 1993-1994. Results: In the Inter99 study, serum 25(OH)D was positively associated with total adiponectin (the effect estimate in % per doubling of 25(OH)D was 4.78, 95% CI: 1.96, 7.68, P<0.001). Using variations in the vitamin D-binding protein gene and the filaggrin gene as instrumental variables, the causal effect in % was estimated to 61.46, 95% CI: 17.51, 120.28, P=0.003 higher adiponectin per doubling of 25(OH)D. In the MONICA10 cohort, no significant association was observed between the serum concentrations of 25(OH)D and HMW adiponectin (the effect estimate in % per doubling of 25(OH)D was-1.51, 95% CI:-5.80, 2.98, P=0.50), although the instrumental variables analysis to some extent supported a positive causal association (the effect estimate in % per doubling of 25(OH)D was 37.13, 95% CI:-3.67, 95.20, P=0.080). Conclusions: The results indicate a possible causal association between serum 25(OH)D and total adiponectin. However, the association was not replicated for HMW adiponectin. Thus, further studies are needed to confirm a causal relationship.

AB - Background/Objectives: The aim was to examine the causal effect of vitamin D on serum adiponectin using a multiple instrument Mendelian randomization approach. Subjects/Methods: Serum 25-hydroxy vitamin D (25(OH)D) and serum total or high molecular weight (HMW) adiponectin were measured in two Danish population-based studies: the Inter99 study (6405 adults, 30-60 years) conducted in 1999-2001, and the MONICA10 study (2656 adults, 41-71 years) conducted in 1993-1994. Results: In the Inter99 study, serum 25(OH)D was positively associated with total adiponectin (the effect estimate in % per doubling of 25(OH)D was 4.78, 95% CI: 1.96, 7.68, P<0.001). Using variations in the vitamin D-binding protein gene and the filaggrin gene as instrumental variables, the causal effect in % was estimated to 61.46, 95% CI: 17.51, 120.28, P=0.003 higher adiponectin per doubling of 25(OH)D. In the MONICA10 cohort, no significant association was observed between the serum concentrations of 25(OH)D and HMW adiponectin (the effect estimate in % per doubling of 25(OH)D was-1.51, 95% CI:-5.80, 2.98, P=0.50), although the instrumental variables analysis to some extent supported a positive causal association (the effect estimate in % per doubling of 25(OH)D was 37.13, 95% CI:-3.67, 95.20, P=0.080). Conclusions: The results indicate a possible causal association between serum 25(OH)D and total adiponectin. However, the association was not replicated for HMW adiponectin. Thus, further studies are needed to confirm a causal relationship.

UR - http://www.scopus.com/inward/record.url?scp=84893731162&partnerID=8YFLogxK

U2 - 10.1038/ejcn.2013.233

DO - 10.1038/ejcn.2013.233

M3 - Journal article

C2 - 24219894

AN - SCOPUS:84893731162

SN - 0954-3007

VL - 68

SP - 189

EP - 195

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

ER -

Investigating the causal effect of vitamin D on serum adiponectin using a mendelian randomization approach

Abstract

Adgang til dokumentet

Andre filer og links

Fingeraftryk

Citationsformater