Intravenous ferric carboxymaltose accelerates erythropoietic recovery from experimental malarial anemia

Lasse Maretty; Rebecca Emilie Sharp; Mikael Andersson; Jørgen A L Kurtzhals

doi:10.1093/infdis/jis020

Intravenous ferric carboxymaltose accelerates erythropoietic recovery from experimental malarial anemia

Lasse Maretty, Rebecca Emilie Sharp, Mikael Andersson, Jørgen A L Kurtzhals

5 Citationer (Scopus)

Abstract

Iron restriction has been proposed as a cause of erythropoietic suppression in malarial anemia; however, the role of iron in malaria remains controversial, because it may increase parasitemia. To investigate the role of iron-restricted erythropoiesis, A/J mice were infected with Plasmodium chabaudi AS, treated with intravenous ferric carboxymaltose at different times, and compared with untreated controls. Iron treatment significantly increased weight and hemoglobin nadirs and provided enhanced reticulocytosis and faster recovery, compared with controls. Our findings challenge the restrictive use of iron therapy in malaria and show the need for trials of intravenous ferric carboxymaltose as an adjunctive treatment for severe malarial anemia.

Originalsprog	Engelsk
Tidsskrift	Journal of Infectious Diseases
Vol/bind	205
Udgave nummer	7
Sider (fra-til)	1173-7
Antal sider	5
ISSN	0022-1899
DOI	https://doi.org/10.1093/infdis/jis020
Status	Udgivet - 1 apr. 2012

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10.1093/infdis/jis020

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title = "Intravenous ferric carboxymaltose accelerates erythropoietic recovery from experimental malarial anemia",

abstract = "Iron restriction has been proposed as a cause of erythropoietic suppression in malarial anemia; however, the role of iron in malaria remains controversial, because it may increase parasitemia. To investigate the role of iron-restricted erythropoiesis, A/J mice were infected with Plasmodium chabaudi AS, treated with intravenous ferric carboxymaltose at different times, and compared with untreated controls. Iron treatment significantly increased weight and hemoglobin nadirs and provided enhanced reticulocytosis and faster recovery, compared with controls. Our findings challenge the restrictive use of iron therapy in malaria and show the need for trials of intravenous ferric carboxymaltose as an adjunctive treatment for severe malarial anemia.",

author = "Lasse Maretty and Sharp, {Rebecca Emilie} and Mikael Andersson and Kurtzhals, {J{\o}rgen A L}",

year = "2012",

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doi = "10.1093/infdis/jis020",

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T1 - Intravenous ferric carboxymaltose accelerates erythropoietic recovery from experimental malarial anemia

AU - Maretty, Lasse

AU - Sharp, Rebecca Emilie

AU - Andersson, Mikael

AU - Kurtzhals, Jørgen A L

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Iron restriction has been proposed as a cause of erythropoietic suppression in malarial anemia; however, the role of iron in malaria remains controversial, because it may increase parasitemia. To investigate the role of iron-restricted erythropoiesis, A/J mice were infected with Plasmodium chabaudi AS, treated with intravenous ferric carboxymaltose at different times, and compared with untreated controls. Iron treatment significantly increased weight and hemoglobin nadirs and provided enhanced reticulocytosis and faster recovery, compared with controls. Our findings challenge the restrictive use of iron therapy in malaria and show the need for trials of intravenous ferric carboxymaltose as an adjunctive treatment for severe malarial anemia.

AB - Iron restriction has been proposed as a cause of erythropoietic suppression in malarial anemia; however, the role of iron in malaria remains controversial, because it may increase parasitemia. To investigate the role of iron-restricted erythropoiesis, A/J mice were infected with Plasmodium chabaudi AS, treated with intravenous ferric carboxymaltose at different times, and compared with untreated controls. Iron treatment significantly increased weight and hemoglobin nadirs and provided enhanced reticulocytosis and faster recovery, compared with controls. Our findings challenge the restrictive use of iron therapy in malaria and show the need for trials of intravenous ferric carboxymaltose as an adjunctive treatment for severe malarial anemia.

U2 - 10.1093/infdis/jis020

DO - 10.1093/infdis/jis020

M3 - Journal article

C2 - 22357662

SN - 0022-1899

VL - 205

SP - 1173

EP - 1177

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 7

ER -

Intravenous ferric carboxymaltose accelerates erythropoietic recovery from experimental malarial anemia

Abstract

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