TY - JOUR
T1 - Intracranial hemodynamics during intravenous infusion of glyceryl trinitrate
AU - Iversen, Helle Klingenberg
AU - Holm, Søren
AU - Friberg, L
AU - Tfelt-Hansen, P
PY - 2008/6
Y1 - 2008/6
N2 - The mechanisms of glyceryl trinitrate (GTN)-induced headache are not fully elucidated. In this study we administered GTN 0.5 microg/kg/min i.v. for 20 min in six healthy volunteers. Before, during and 60 min after the infusion, we investigated regional cerebral blood flow (rCBF), cerebral blood volume (CBV), both estimated with SPECT, and blood flow velocity (BFV) in the middle cerebral artery (MCA), measured with transcranial Doppler. Headache was scored on a numerical verbal rating (0-10) scale. rCBF was unchanged, CBV was slightly increased (13%) during GTN infusion, whereas BFV decreased both during (20%) and 60 min (15%) after GTN. Headache was short-lived and maximal during infusion. This discrepancy of time-effect curves for the effect of GTN on headache and dilatation of MCA indicates that MCA is most likely not the primary source of pain in GTN-induced headache. The time-effect curves for the effect of GTN on headache and on dilation of MCA differed markedly. This indicates that MCA is most likely not the primary source of pain in GTN-induced headache.
AB - The mechanisms of glyceryl trinitrate (GTN)-induced headache are not fully elucidated. In this study we administered GTN 0.5 microg/kg/min i.v. for 20 min in six healthy volunteers. Before, during and 60 min after the infusion, we investigated regional cerebral blood flow (rCBF), cerebral blood volume (CBV), both estimated with SPECT, and blood flow velocity (BFV) in the middle cerebral artery (MCA), measured with transcranial Doppler. Headache was scored on a numerical verbal rating (0-10) scale. rCBF was unchanged, CBV was slightly increased (13%) during GTN infusion, whereas BFV decreased both during (20%) and 60 min (15%) after GTN. Headache was short-lived and maximal during infusion. This discrepancy of time-effect curves for the effect of GTN on headache and dilatation of MCA indicates that MCA is most likely not the primary source of pain in GTN-induced headache. The time-effect curves for the effect of GTN on headache and on dilation of MCA differed markedly. This indicates that MCA is most likely not the primary source of pain in GTN-induced headache.
KW - Adult
KW - Blood Flow Velocity
KW - Cerebrovascular Circulation
KW - Female
KW - Hemodynamics
KW - Humans
KW - Infusions, Intravenous
KW - Male
KW - Middle Cerebral Artery
KW - Nitroglycerin
KW - Pain
KW - Time Factors
KW - Tomography, Emission-Computed, Single-Photon
KW - Ultrasonography, Doppler, Transcranial
KW - Vasodilator Agents
U2 - 10.1007/s10194-008-0034-x
DO - 10.1007/s10194-008-0034-x
M3 - Journal article
C2 - 18401549
SN - 1129-2369
VL - 9
SP - 177
EP - 180
JO - Journal of Headache and Pain
JF - Journal of Headache and Pain
IS - 3
ER -