Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

TY - JOUR

T1 - Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

AU - Wahlström, Annika

AU - Sayin, Sama I

AU - Marschall, Hanns-Ulrich

AU - Bäckhed, Gert Fredrik

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2016/7/12

Y1 - 2016/7/12

N2 - The gut microbiota is considered a metabolic "organ" that not only facilitates harvesting of nutrients and energy from the ingested food but also produces numerous metabolites that signal through their cognate receptors to regulate host metabolism. One such class of metabolites, bile acids, is produced in the liver from cholesterol and metabolized in the intestine by the gut microbiota. These bioconversions modulate the signaling properties of bile acids via the nuclear farnesoid X receptor and the G protein-coupled membrane receptor 5, which regulate numerous metabolic pathways in the host. Conversely, bile acids can modulate gut microbial composition both directly and indirectly through activation of innate immune genes in the small intestine. Thus, host metabolism can be affected through microbial modifications of bile acids, which lead to altered signaling via bile acid receptors, but also by altered microbiota composition.

AB - The gut microbiota is considered a metabolic "organ" that not only facilitates harvesting of nutrients and energy from the ingested food but also produces numerous metabolites that signal through their cognate receptors to regulate host metabolism. One such class of metabolites, bile acids, is produced in the liver from cholesterol and metabolized in the intestine by the gut microbiota. These bioconversions modulate the signaling properties of bile acids via the nuclear farnesoid X receptor and the G protein-coupled membrane receptor 5, which regulate numerous metabolic pathways in the host. Conversely, bile acids can modulate gut microbial composition both directly and indirectly through activation of innate immune genes in the small intestine. Thus, host metabolism can be affected through microbial modifications of bile acids, which lead to altered signaling via bile acid receptors, but also by altered microbiota composition.

KW - Journal Article

KW - Review

U2 - 10.1016/j.cmet.2016.05.005

DO - 10.1016/j.cmet.2016.05.005

M3 - Review

C2 - 27320064

SN - 1550-4131

VL - 24

SP - 41

EP - 50

JO - Cell Metabolism

JF - Cell Metabolism

IS - 1

ER -