Interval Walking Improves Glycemic Control and Body Composition After Cancer Treatment: A Randomized Controlled Trial

Jesper F. Christensen; Anna Sundberg; Jens Osterkamp; Sarah Thorsen-Streit; Anette B. Nielsen; Cecilie K. Olsen; Sissal S. Djurhuus; Casper Simonsen; Tim Schauer; Helga Ellingsgaard; Kell Østerlind; Peter Martin Krarup; Camilla Mosgaard; Kirsten Vistisen; Anders Tolver; Bente K. Pedersen; Pernille Hojman

doi:10.1210/jc.2019-00590

Interval Walking Improves Glycemic Control and Body Composition After Cancer Treatment: A Randomized Controlled Trial

Jesper F. Christensen, Anna Sundberg, Jens Osterkamp, Sarah Thorsen-Streit, Anette B. Nielsen, Cecilie K. Olsen, Sissal S. Djurhuus, Casper Simonsen, Tim Schauer, Helga Ellingsgaard, Kell Østerlind, Peter Martin Krarup, Camilla Mosgaard, Kirsten Vistisen, Anders Tolver, Bente K. Pedersen, Pernille Hojman

2 Citationer (Scopus)

Abstract

Context: Patients with colorectal cancer have increased risk of metabolic diseases including diabetes. Exercise training may counteract metabolic dysregulation, but the impact of exercise training on glycemic control, including postprandial glycemia, has never been explored in patients with colorectal cancer. Objective: To examine the effects of home-based interval walking on aerobic and metabolic fitness and quality of life in patients with colorectal cancer. Design: Randomized controlled trial. Setting: Clinical research center. Participants: Thirty-nine sedentary (<150 minutes moderate-intensity exercise per week) patients with stage I to III colorectal cancer who had completed primary treatment. Intervention: Home-based interval walking 150 min/wk or usual care for 12 weeks. Main Outcome Measures: Changes from baseline to week 12 in maximum oxygen uptake (VO_2peak) by cardiopulmonary exercise test, glycemic control by oral glucose tolerance test (OGTT), body composition by dual-energy x-ray absorptiometry scan, blood biochemistry, and quality of life. Results: Compared with control, interval walking had no effect on VO_2peak [mean between-group difference: -0.32 mL O₂ · kg^-1 · min^-1 (-2.09 to 1.45); P = 0.721] but significantly improved postprandial glycemic control with lower glucose OGTT area under the curve [-126 mM · min (-219 to -33); P = 0.009], 2-hour glucose concentration [-1.1 mM (-2.2 to 0.0); P = 0.056], and improved Matsuda index [1.94 (0.34; 3.54); P = 0.01]. Also, interval walking counteracted an increase in fat mass in the control group [-1.47 kg (-2.74 to -0.19); P = 0.025]. Conclusion: A home-based interval-walking program led to substantial improvements in postprandial glycemic control and counteracted fat gain in posttreatment patients with colorectal cancer, possibly providing an effective strategy for prevention of secondary metabolic diseases.

Originalsprog	Engelsk
Tidsskrift	The Journal of clinical endocrinology and metabolism
Vol/bind	104
Udgave nummer	9
Sider (fra-til)	3701-3712
Antal sider	12
ISSN	0021-972X
DOI	https://doi.org/10.1210/jc.2019-00590
Status	Udgivet - 11 apr. 2019

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Christensen, J. F., Sundberg, A., Osterkamp, J., Thorsen-Streit, S., Nielsen, A. B., Olsen, C. K., Djurhuus, S. S., Simonsen, C., Schauer, T., Ellingsgaard, H., Østerlind, K., Krarup, P. M., Mosgaard, C., Vistisen, K., Tolver, A., Pedersen, B. K., & Hojman, P. (2019). Interval Walking Improves Glycemic Control and Body Composition After Cancer Treatment: A Randomized Controlled Trial. The Journal of clinical endocrinology and metabolism, 104(9), 3701-3712. https://doi.org/10.1210/jc.2019-00590

Christensen, JF, Sundberg, A, Osterkamp, J, Thorsen-Streit, S, Nielsen, AB, Olsen, CK, Djurhuus, SS, Simonsen, C, Schauer, T, Ellingsgaard, H, Østerlind, K, Krarup, PM, Mosgaard, C, Vistisen, K, Tolver, A , Pedersen, BK & Hojman, P 2019, 'Interval Walking Improves Glycemic Control and Body Composition After Cancer Treatment: A Randomized Controlled Trial', The Journal of clinical endocrinology and metabolism, bind 104, nr. 9, s. 3701-3712. https://doi.org/10.1210/jc.2019-00590

@article{ded1abe7e79e408bb99fe206acc39823,

title = "Interval Walking Improves Glycemic Control and Body Composition After Cancer Treatment: A Randomized Controlled Trial",

abstract = "Context: Patients with colorectal cancer have increased risk of metabolic diseases including diabetes. Exercise training may counteract metabolic dysregulation, but the impact of exercise training on glycemic control, including postprandial glycemia, has never been explored in patients with colorectal cancer. Objective: To examine the effects of home-based interval walking on aerobic and metabolic fitness and quality of life in patients with colorectal cancer. Design: Randomized controlled trial. Setting: Clinical research center. Participants: Thirty-nine sedentary (<150 minutes moderate-intensity exercise per week) patients with stage I to III colorectal cancer who had completed primary treatment. Intervention: Home-based interval walking 150 min/wk or usual care for 12 weeks. Main Outcome Measures: Changes from baseline to week 12 in maximum oxygen uptake (VO2peak) by cardiopulmonary exercise test, glycemic control by oral glucose tolerance test (OGTT), body composition by dual-energy x-ray absorptiometry scan, blood biochemistry, and quality of life. Results: Compared with control, interval walking had no effect on VO2peak [mean between-group difference: -0.32 mL O2 · kg-1 · min-1 (-2.09 to 1.45); P = 0.721] but significantly improved postprandial glycemic control with lower glucose OGTT area under the curve [-126 mM · min (-219 to -33); P = 0.009], 2-hour glucose concentration [-1.1 mM (-2.2 to 0.0); P = 0.056], and improved Matsuda index [1.94 (0.34; 3.54); P = 0.01]. Also, interval walking counteracted an increase in fat mass in the control group [-1.47 kg (-2.74 to -0.19); P = 0.025]. Conclusion: A home-based interval-walking program led to substantial improvements in postprandial glycemic control and counteracted fat gain in posttreatment patients with colorectal cancer, possibly providing an effective strategy for prevention of secondary metabolic diseases.",

author = "Christensen, {Jesper F.} and Anna Sundberg and Jens Osterkamp and Sarah Thorsen-Streit and Nielsen, {Anette B.} and Olsen, {Cecilie K.} and Djurhuus, {Sissal S.} and Casper Simonsen and Tim Schauer and Helga Ellingsgaard and Kell {\O}sterlind and Krarup, {Peter Martin} and Camilla Mosgaard and Kirsten Vistisen and Anders Tolver and Pedersen, {Bente K.} and Pernille Hojman",

year = "2019",

month = apr,

day = "11",

doi = "10.1210/jc.2019-00590",

language = "English",

volume = "104",

pages = "3701--3712",

journal = "The Journal of clinical endocrinology and metabolism",

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T1 - Interval Walking Improves Glycemic Control and Body Composition After Cancer Treatment

T2 - A Randomized Controlled Trial

AU - Christensen, Jesper F.

AU - Sundberg, Anna

AU - Osterkamp, Jens

AU - Thorsen-Streit, Sarah

AU - Nielsen, Anette B.

AU - Olsen, Cecilie K.

AU - Djurhuus, Sissal S.

AU - Simonsen, Casper

AU - Schauer, Tim

AU - Ellingsgaard, Helga

AU - Østerlind, Kell

AU - Krarup, Peter Martin

AU - Mosgaard, Camilla

AU - Vistisen, Kirsten

AU - Tolver, Anders

AU - Pedersen, Bente K.

AU - Hojman, Pernille

PY - 2019/4/11

Y1 - 2019/4/11

N2 - Context: Patients with colorectal cancer have increased risk of metabolic diseases including diabetes. Exercise training may counteract metabolic dysregulation, but the impact of exercise training on glycemic control, including postprandial glycemia, has never been explored in patients with colorectal cancer. Objective: To examine the effects of home-based interval walking on aerobic and metabolic fitness and quality of life in patients with colorectal cancer. Design: Randomized controlled trial. Setting: Clinical research center. Participants: Thirty-nine sedentary (<150 minutes moderate-intensity exercise per week) patients with stage I to III colorectal cancer who had completed primary treatment. Intervention: Home-based interval walking 150 min/wk or usual care for 12 weeks. Main Outcome Measures: Changes from baseline to week 12 in maximum oxygen uptake (VO2peak) by cardiopulmonary exercise test, glycemic control by oral glucose tolerance test (OGTT), body composition by dual-energy x-ray absorptiometry scan, blood biochemistry, and quality of life. Results: Compared with control, interval walking had no effect on VO2peak [mean between-group difference: -0.32 mL O2 · kg-1 · min-1 (-2.09 to 1.45); P = 0.721] but significantly improved postprandial glycemic control with lower glucose OGTT area under the curve [-126 mM · min (-219 to -33); P = 0.009], 2-hour glucose concentration [-1.1 mM (-2.2 to 0.0); P = 0.056], and improved Matsuda index [1.94 (0.34; 3.54); P = 0.01]. Also, interval walking counteracted an increase in fat mass in the control group [-1.47 kg (-2.74 to -0.19); P = 0.025]. Conclusion: A home-based interval-walking program led to substantial improvements in postprandial glycemic control and counteracted fat gain in posttreatment patients with colorectal cancer, possibly providing an effective strategy for prevention of secondary metabolic diseases.

AB - Context: Patients with colorectal cancer have increased risk of metabolic diseases including diabetes. Exercise training may counteract metabolic dysregulation, but the impact of exercise training on glycemic control, including postprandial glycemia, has never been explored in patients with colorectal cancer. Objective: To examine the effects of home-based interval walking on aerobic and metabolic fitness and quality of life in patients with colorectal cancer. Design: Randomized controlled trial. Setting: Clinical research center. Participants: Thirty-nine sedentary (<150 minutes moderate-intensity exercise per week) patients with stage I to III colorectal cancer who had completed primary treatment. Intervention: Home-based interval walking 150 min/wk or usual care for 12 weeks. Main Outcome Measures: Changes from baseline to week 12 in maximum oxygen uptake (VO2peak) by cardiopulmonary exercise test, glycemic control by oral glucose tolerance test (OGTT), body composition by dual-energy x-ray absorptiometry scan, blood biochemistry, and quality of life. Results: Compared with control, interval walking had no effect on VO2peak [mean between-group difference: -0.32 mL O2 · kg-1 · min-1 (-2.09 to 1.45); P = 0.721] but significantly improved postprandial glycemic control with lower glucose OGTT area under the curve [-126 mM · min (-219 to -33); P = 0.009], 2-hour glucose concentration [-1.1 mM (-2.2 to 0.0); P = 0.056], and improved Matsuda index [1.94 (0.34; 3.54); P = 0.01]. Also, interval walking counteracted an increase in fat mass in the control group [-1.47 kg (-2.74 to -0.19); P = 0.025]. Conclusion: A home-based interval-walking program led to substantial improvements in postprandial glycemic control and counteracted fat gain in posttreatment patients with colorectal cancer, possibly providing an effective strategy for prevention of secondary metabolic diseases.

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Interval Walking Improves Glycemic Control and Body Composition After Cancer Treatment: A Randomized Controlled Trial

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