Interplay Between Long Noncoding RNAs and MicroRNAs in Cancer

TY - CHAP

T1 - Interplay Between Long Noncoding RNAs and MicroRNAs in Cancer

AU - Russo, Francesco

AU - Fiscon, Giulia

AU - Conte, Federica

AU - Rizzo, Milena

AU - Paci, Paola

AU - Pellegrini, Marco

PY - 2018

Y1 - 2018

N2 - In the last decade noncoding RNAs (ncRNAs) have been extensively studied in several biological processes and human diseases including cancer. microRNAs (miRNAs) are the best-known class of ncRNAs. miRNAs are small ncRNAs of around 20-22 nucleotides (nt) and are crucial posttranscriptional regulators of protein coding genes. Recently, new classes of ncRNAs, longer than miRNAs have been discovered. Those include intergenic noncoding RNAs (lincRNAs) and circular RNAs (circRNAs). These novel types of ncRNAs opened a very exciting field in biology, leading researchers to discover new relationships between miRNAs and long noncoding RNAs (lncRNAs), which act together to control protein coding gene expression. One of these new discoveries led to the formulation of the "competing endogenous RNA (ceRNA) hypothesis." This hypothesis suggests that an lncRNA acts as a sponge for miRNAs reducing their expression and causing the upregulation of miRNA targets. In this chapter we first discuss some recent discoveries in this field showing the mutual regulation of miRNAs, lncRNAs, and protein-coding genes in cancer. We then discuss the general approaches for the study of ceRNAs and present in more detail a recent computational approach to explore the ability of lncRNAs to act as ceRNAs in human breast cancer that has been shown to be, among the others, the most precise and promising.

AB - In the last decade noncoding RNAs (ncRNAs) have been extensively studied in several biological processes and human diseases including cancer. microRNAs (miRNAs) are the best-known class of ncRNAs. miRNAs are small ncRNAs of around 20-22 nucleotides (nt) and are crucial posttranscriptional regulators of protein coding genes. Recently, new classes of ncRNAs, longer than miRNAs have been discovered. Those include intergenic noncoding RNAs (lincRNAs) and circular RNAs (circRNAs). These novel types of ncRNAs opened a very exciting field in biology, leading researchers to discover new relationships between miRNAs and long noncoding RNAs (lncRNAs), which act together to control protein coding gene expression. One of these new discoveries led to the formulation of the "competing endogenous RNA (ceRNA) hypothesis." This hypothesis suggests that an lncRNA acts as a sponge for miRNAs reducing their expression and causing the upregulation of miRNA targets. In this chapter we first discuss some recent discoveries in this field showing the mutual regulation of miRNAs, lncRNAs, and protein-coding genes in cancer. We then discuss the general approaches for the study of ceRNAs and present in more detail a recent computational approach to explore the ability of lncRNAs to act as ceRNAs in human breast cancer that has been shown to be, among the others, the most precise and promising.

KW - Cancer

KW - Competing endogenous RNAs

KW - Host genes

KW - Long noncoding RNA-derived microRNAs

KW - Long noncoding RNAs

KW - MicroRNAs

KW - Sponge

U2 - 10.1007/978-1-4939-8618-7_4

DO - 10.1007/978-1-4939-8618-7_4

M3 - Book chapter

C2 - 30421400

SN - 978-1-4939-8617-0

T3 - Methods in Molecular Biology

SP - 75

EP - 92

BT - Computational Cell Biology

A2 - von Stechow, Louise

A2 - Delgado, Alberto Santos

PB - Humana Press

ER -