Interplay between food and gut microbiota in health and disease

Niels Banhos Danneskiold-Samsøe; Helena Dias de Freitas Queiroz Barros; Rosangela Santos; Juliano Lemos Bicas; Cinthia Baú Betim Cazarin; Lise Madsen; Karsten Kristiansen; Glaucia Maria Pastore; Susanne Brix; Mário Roberto Maróstica Júnior

doi:10.1016/j.foodres.2018.07.043

Interplay between food and gut microbiota in health and disease

Niels Banhos Danneskiold-Samsøe, Helena Dias de Freitas Queiroz Barros, Rosangela Santos, Juliano Lemos Bicas, Cinthia Baú Betim Cazarin, Lise Madsen, Karsten Kristiansen^*, Glaucia Maria Pastore, Susanne Brix, Mário Roberto Maróstica Júnior

^*Corresponding author af dette arbejde

Genomforskning og Molekylær Biomedicin

64 Citationer (Scopus)

Abstract

Numerous microorganisms colonize the human gastrointestinal tract playing pivotal roles in relation to digestion and absorption of dietary components. They biotransform food components and produce metabolites, which in combination with food components shape and modulate the host immune system and metabolic responses. Reciprocally, the diet modulates the composition and functional capacity of the gut microbiota, which subsequently influence host biochemical processes establishing a system of mutual interaction and inter-dependency. Macronutrients, fibers, as well as polyphenols and prebiotics are strong drivers shaping the composition of the gut microbiota. Especially, short-chain fatty acids produced from ingested fibers and tryptophan metabolites are key in modulating host immune responses. Since reciprocal interactions between diet, host, and microbiota are personal, understanding this complex network of interactions calls for novel use of large datasets and the implementation of machine learning algorithms and artificial intelligence. In this review, we aim to provide a base for future investigations of how interactions between food components and gut microbiota may influence or even determine human health and disease.

Originalsprog	Engelsk
Tidsskrift	Food Research International
Vol/bind	115
Sider (fra-til)	23-31
ISSN	0963-9969
DOI	https://doi.org/10.1016/j.foodres.2018.07.043
Status	Udgivet - jan. 2019

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10.1016/j.foodres.2018.07.043

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title = "Interplay between food and gut microbiota in health and disease",

abstract = "Numerous microorganisms colonize the human gastrointestinal tract playing pivotal roles in relation to digestion and absorption of dietary components. They biotransform food components and produce metabolites, which in combination with food components shape and modulate the host immune system and metabolic responses. Reciprocally, the diet modulates the composition and functional capacity of the gut microbiota, which subsequently influence host biochemical processes establishing a system of mutual interaction and inter-dependency. Macronutrients, fibers, as well as polyphenols and prebiotics are strong drivers shaping the composition of the gut microbiota. Especially, short-chain fatty acids produced from ingested fibers and tryptophan metabolites are key in modulating host immune responses. Since reciprocal interactions between diet, host, and microbiota are personal, understanding this complex network of interactions calls for novel use of large datasets and the implementation of machine learning algorithms and artificial intelligence. In this review, we aim to provide a base for future investigations of how interactions between food components and gut microbiota may influence or even determine human health and disease.",

keywords = "Disease, Gut microbiota, Health, Macronutrients, Polyphenols, Prebiotics",

author = "Danneskiold-Sams{\o}e, {Niels Banhos} and {Dias de Freitas Queiroz Barros}, Helena and Rosangela Santos and Bicas, {Juliano Lemos} and Cazarin, {Cinthia Ba{\'u} Betim} and Lise Madsen and Karsten Kristiansen and Pastore, {Glaucia Maria} and Susanne Brix and {Mar{\'o}stica J{\'u}nior}, {M{\'a}rio Roberto}",

year = "2019",

month = jan,

doi = "10.1016/j.foodres.2018.07.043",

language = "English",

volume = "115",

pages = "23--31",

journal = "Food Research International",

issn = "0963-9969",

publisher = "Pergamon Press",

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AU - Danneskiold-Samsøe, Niels Banhos

AU - Dias de Freitas Queiroz Barros, Helena

AU - Santos, Rosangela

AU - Bicas, Juliano Lemos

AU - Cazarin, Cinthia Baú Betim

AU - Madsen, Lise

AU - Kristiansen, Karsten

AU - Pastore, Glaucia Maria

AU - Brix, Susanne

AU - Maróstica Júnior, Mário Roberto

PY - 2019/1

Y1 - 2019/1

N2 - Numerous microorganisms colonize the human gastrointestinal tract playing pivotal roles in relation to digestion and absorption of dietary components. They biotransform food components and produce metabolites, which in combination with food components shape and modulate the host immune system and metabolic responses. Reciprocally, the diet modulates the composition and functional capacity of the gut microbiota, which subsequently influence host biochemical processes establishing a system of mutual interaction and inter-dependency. Macronutrients, fibers, as well as polyphenols and prebiotics are strong drivers shaping the composition of the gut microbiota. Especially, short-chain fatty acids produced from ingested fibers and tryptophan metabolites are key in modulating host immune responses. Since reciprocal interactions between diet, host, and microbiota are personal, understanding this complex network of interactions calls for novel use of large datasets and the implementation of machine learning algorithms and artificial intelligence. In this review, we aim to provide a base for future investigations of how interactions between food components and gut microbiota may influence or even determine human health and disease.

AB - Numerous microorganisms colonize the human gastrointestinal tract playing pivotal roles in relation to digestion and absorption of dietary components. They biotransform food components and produce metabolites, which in combination with food components shape and modulate the host immune system and metabolic responses. Reciprocally, the diet modulates the composition and functional capacity of the gut microbiota, which subsequently influence host biochemical processes establishing a system of mutual interaction and inter-dependency. Macronutrients, fibers, as well as polyphenols and prebiotics are strong drivers shaping the composition of the gut microbiota. Especially, short-chain fatty acids produced from ingested fibers and tryptophan metabolites are key in modulating host immune responses. Since reciprocal interactions between diet, host, and microbiota are personal, understanding this complex network of interactions calls for novel use of large datasets and the implementation of machine learning algorithms and artificial intelligence. In this review, we aim to provide a base for future investigations of how interactions between food components and gut microbiota may influence or even determine human health and disease.

KW - Disease

KW - Gut microbiota

KW - Health

KW - Macronutrients

KW - Polyphenols

KW - Prebiotics

U2 - 10.1016/j.foodres.2018.07.043

DO - 10.1016/j.foodres.2018.07.043

M3 - Review

C2 - 30599936

AN - SCOPUS:85053059806

SN - 0963-9969

VL - 115

SP - 23

EP - 31

JO - Food Research International

JF - Food Research International

ER -

Interplay between food and gut microbiota in health and disease

Abstract

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