Intermittent Standing but not a Moderate Exercise Bout Reduces Postprandial Glycemia

Fabiana B Benatti; Sidsel A Larsen; Katja Kofoed; Signe T Nielsen; Nina M Harder-Lauridsen; Mark P Lyngbæk; Dorte Eriksen; Kristian Karstoft; Rikke Krogh-Madsen; Bente K Pedersen; Mathias Ried-Larsen

doi:10.1249/MSS.0000000000001354

Intermittent Standing but not a Moderate Exercise Bout Reduces Postprandial Glycemia

Fabiana B Benatti, Sidsel A Larsen, Katja Kofoed, Signe T Nielsen, Nina M Harder-Lauridsen, Mark P Lyngbæk, Dorte Eriksen, Kristian Karstoft, Rikke Krogh-Madsen, Bente K Pedersen, Mathias Ried-Larsen

Institut for Klinisk Medicin

18 Citationer (Scopus)

Abstract

PURPOSE: This study aimed to determine whether minimum recommended moderate-to-vigorous physical activity (MVPA; 30-min bout of continuous moderate-intensity walking) is sufficient to counteract the detrimental effects of prolonged sitting on postprandial metabolism and if there are any effects of breaking up sitting with intermittent standing when achieving minimum recommended MVPA.

METHODS: Fourteen (n = 14) physically inactive healthy adult males underwent four intrahospital 27-h interventions: 9-h continuous sitting (SIT), 15-min standing bouts every 30 min during the 9-h sitting (STAND), 30-min moderate-intensity walking bout followed by 8.5 h of sitting (MVPA), and 30-min moderate-intensity walking bout followed by 15-min standing bouts every 30 min during 8.5 h of sitting (MVPA + STAND). Three standardized meals on intervention day (day 1) and breakfast the following day (day 2) were served.

RESULTS: Cumulative postprandial glucose response (incremental area under the curve) was lower in STAND versus SIT (↓27%, P = 0.04, effect size [ES] = -0.7) because of decreases in postprandial glucose after breakfast on day 1 (STAND vs SIT: ↓40%, P = 0.01, ES = -0.7) and day 2 (STAND vs SIT: ↓33%, P = 0.06, ES = -0.6). STAND did not affect postprandial insulin responses. Cumulative postprandial insulin response was lower in MVPA versus SIT (↓18%, P = 0.03, ES = -0.3) and MVPA + STAND versus SIT (↓26%, P = 0.02, ES = -0.4) because of expected exercise-induced decreases in postprandial insulin after breakfast on day 1 only (MVPA vs SIT: ↓36%, P = 0.003, ES = -0.7; MVPA + STAND vs SIT: ↓43%, P = 0.0001, ES = -0.8).

CONCLUSION: Breaking up prolonged sitting with nonambulatory standing across 9 h acutely reduced postprandial glycemic response during and the day after the intervention independent of insulin levels, whereas a 30-min MVPA bout did not.

Originalsprog	Engelsk
Tidsskrift	Medicine and Science in Sports and Exercise
Vol/bind	49
Udgave nummer	11
Sider (fra-til)	2305-2314
ISSN	0195-9131
DOI	https://doi.org/10.1249/MSS.0000000000001354
Status	Udgivet - 1 nov. 2017

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10.1249/MSS.0000000000001354

Citationsformater

Benatti, F. B., Larsen, S. A., Kofoed, K., Nielsen, S. T., Harder-Lauridsen, N. M., Lyngbæk, M. P., Eriksen, D., Karstoft, K., Krogh-Madsen, R., Pedersen, B. K., & Ried-Larsen, M. (2017). Intermittent Standing but not a Moderate Exercise Bout Reduces Postprandial Glycemia. Medicine and Science in Sports and Exercise, 49(11), 2305-2314. https://doi.org/10.1249/MSS.0000000000001354

Benatti, FB, Larsen, SA, Kofoed, K, Nielsen, ST, Harder-Lauridsen, NM, Lyngbæk, MP, Eriksen, D, Karstoft, K, Krogh-Madsen, R , Pedersen, BK & Ried-Larsen, M 2017, 'Intermittent Standing but not a Moderate Exercise Bout Reduces Postprandial Glycemia', Medicine and Science in Sports and Exercise, bind 49, nr. 11, s. 2305-2314. https://doi.org/10.1249/MSS.0000000000001354

@article{b4b4f3b435db4f21b6a83c98394f5391,

title = "Intermittent Standing but not a Moderate Exercise Bout Reduces Postprandial Glycemia",

abstract = "PURPOSE: This study aimed to determine whether minimum recommended moderate-to-vigorous physical activity (MVPA; 30-min bout of continuous moderate-intensity walking) is sufficient to counteract the detrimental effects of prolonged sitting on postprandial metabolism and if there are any effects of breaking up sitting with intermittent standing when achieving minimum recommended MVPA.METHODS: Fourteen (n = 14) physically inactive healthy adult males underwent four intrahospital 27-h interventions: 9-h continuous sitting (SIT), 15-min standing bouts every 30 min during the 9-h sitting (STAND), 30-min moderate-intensity walking bout followed by 8.5 h of sitting (MVPA), and 30-min moderate-intensity walking bout followed by 15-min standing bouts every 30 min during 8.5 h of sitting (MVPA + STAND). Three standardized meals on intervention day (day 1) and breakfast the following day (day 2) were served.RESULTS: Cumulative postprandial glucose response (incremental area under the curve) was lower in STAND versus SIT (↓27%, P = 0.04, effect size [ES] = -0.7) because of decreases in postprandial glucose after breakfast on day 1 (STAND vs SIT: ↓40%, P = 0.01, ES = -0.7) and day 2 (STAND vs SIT: ↓33%, P = 0.06, ES = -0.6). STAND did not affect postprandial insulin responses. Cumulative postprandial insulin response was lower in MVPA versus SIT (↓18%, P = 0.03, ES = -0.3) and MVPA + STAND versus SIT (↓26%, P = 0.02, ES = -0.4) because of expected exercise-induced decreases in postprandial insulin after breakfast on day 1 only (MVPA vs SIT: ↓36%, P = 0.003, ES = -0.7; MVPA + STAND vs SIT: ↓43%, P = 0.0001, ES = -0.8).CONCLUSION: Breaking up prolonged sitting with nonambulatory standing across 9 h acutely reduced postprandial glycemic response during and the day after the intervention independent of insulin levels, whereas a 30-min MVPA bout did not.",

keywords = "Adult, Blood Glucose/metabolism, Body Composition/physiology, C-Peptide/blood, Cross-Over Studies, Eating/physiology, Energy Metabolism/physiology, Exercise/physiology, Glucose Tolerance Test, Humans, Lipids/blood, Male, Middle Aged, Oxygen Consumption/physiology, Postprandial Period/physiology, Posture/physiology, Young Adult",

author = "Benatti, {Fabiana B} and Larsen, {Sidsel A} and Katja Kofoed and Nielsen, {Signe T} and Harder-Lauridsen, {Nina M} and Lyngb{\ae}k, {Mark P} and Dorte Eriksen and Kristian Karstoft and Rikke Krogh-Madsen and Pedersen, {Bente K} and Mathias Ried-Larsen",

year = "2017",

month = nov,

day = "1",

doi = "10.1249/MSS.0000000000001354",

language = "English",

volume = "49",

pages = "2305--2314",

journal = "Medicine and Science in Sports and Exercise",

issn = "0195-9131",

publisher = "Lippincott Williams & Wilkins",

number = "11",

}

TY - JOUR

T1 - Intermittent Standing but not a Moderate Exercise Bout Reduces Postprandial Glycemia

AU - Benatti, Fabiana B

AU - Larsen, Sidsel A

AU - Kofoed, Katja

AU - Nielsen, Signe T

AU - Harder-Lauridsen, Nina M

AU - Lyngbæk, Mark P

AU - Eriksen, Dorte

AU - Karstoft, Kristian

AU - Krogh-Madsen, Rikke

AU - Pedersen, Bente K

AU - Ried-Larsen, Mathias

PY - 2017/11/1

Y1 - 2017/11/1

N2 - PURPOSE: This study aimed to determine whether minimum recommended moderate-to-vigorous physical activity (MVPA; 30-min bout of continuous moderate-intensity walking) is sufficient to counteract the detrimental effects of prolonged sitting on postprandial metabolism and if there are any effects of breaking up sitting with intermittent standing when achieving minimum recommended MVPA.METHODS: Fourteen (n = 14) physically inactive healthy adult males underwent four intrahospital 27-h interventions: 9-h continuous sitting (SIT), 15-min standing bouts every 30 min during the 9-h sitting (STAND), 30-min moderate-intensity walking bout followed by 8.5 h of sitting (MVPA), and 30-min moderate-intensity walking bout followed by 15-min standing bouts every 30 min during 8.5 h of sitting (MVPA + STAND). Three standardized meals on intervention day (day 1) and breakfast the following day (day 2) were served.RESULTS: Cumulative postprandial glucose response (incremental area under the curve) was lower in STAND versus SIT (↓27%, P = 0.04, effect size [ES] = -0.7) because of decreases in postprandial glucose after breakfast on day 1 (STAND vs SIT: ↓40%, P = 0.01, ES = -0.7) and day 2 (STAND vs SIT: ↓33%, P = 0.06, ES = -0.6). STAND did not affect postprandial insulin responses. Cumulative postprandial insulin response was lower in MVPA versus SIT (↓18%, P = 0.03, ES = -0.3) and MVPA + STAND versus SIT (↓26%, P = 0.02, ES = -0.4) because of expected exercise-induced decreases in postprandial insulin after breakfast on day 1 only (MVPA vs SIT: ↓36%, P = 0.003, ES = -0.7; MVPA + STAND vs SIT: ↓43%, P = 0.0001, ES = -0.8).CONCLUSION: Breaking up prolonged sitting with nonambulatory standing across 9 h acutely reduced postprandial glycemic response during and the day after the intervention independent of insulin levels, whereas a 30-min MVPA bout did not.

AB - PURPOSE: This study aimed to determine whether minimum recommended moderate-to-vigorous physical activity (MVPA; 30-min bout of continuous moderate-intensity walking) is sufficient to counteract the detrimental effects of prolonged sitting on postprandial metabolism and if there are any effects of breaking up sitting with intermittent standing when achieving minimum recommended MVPA.METHODS: Fourteen (n = 14) physically inactive healthy adult males underwent four intrahospital 27-h interventions: 9-h continuous sitting (SIT), 15-min standing bouts every 30 min during the 9-h sitting (STAND), 30-min moderate-intensity walking bout followed by 8.5 h of sitting (MVPA), and 30-min moderate-intensity walking bout followed by 15-min standing bouts every 30 min during 8.5 h of sitting (MVPA + STAND). Three standardized meals on intervention day (day 1) and breakfast the following day (day 2) were served.RESULTS: Cumulative postprandial glucose response (incremental area under the curve) was lower in STAND versus SIT (↓27%, P = 0.04, effect size [ES] = -0.7) because of decreases in postprandial glucose after breakfast on day 1 (STAND vs SIT: ↓40%, P = 0.01, ES = -0.7) and day 2 (STAND vs SIT: ↓33%, P = 0.06, ES = -0.6). STAND did not affect postprandial insulin responses. Cumulative postprandial insulin response was lower in MVPA versus SIT (↓18%, P = 0.03, ES = -0.3) and MVPA + STAND versus SIT (↓26%, P = 0.02, ES = -0.4) because of expected exercise-induced decreases in postprandial insulin after breakfast on day 1 only (MVPA vs SIT: ↓36%, P = 0.003, ES = -0.7; MVPA + STAND vs SIT: ↓43%, P = 0.0001, ES = -0.8).CONCLUSION: Breaking up prolonged sitting with nonambulatory standing across 9 h acutely reduced postprandial glycemic response during and the day after the intervention independent of insulin levels, whereas a 30-min MVPA bout did not.

KW - Adult

KW - Blood Glucose/metabolism

KW - Body Composition/physiology

KW - C-Peptide/blood

KW - Cross-Over Studies

KW - Eating/physiology

KW - Energy Metabolism/physiology

KW - Exercise/physiology

KW - Glucose Tolerance Test

KW - Humans

KW - Lipids/blood

KW - Male

KW - Middle Aged

KW - Oxygen Consumption/physiology

KW - Postprandial Period/physiology

KW - Posture/physiology

KW - Young Adult

U2 - 10.1249/MSS.0000000000001354

DO - 10.1249/MSS.0000000000001354

M3 - Journal article

C2 - 28640061

SN - 0195-9131

VL - 49

SP - 2305

EP - 2314

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

IS - 11

ER -

Intermittent Standing but not a Moderate Exercise Bout Reduces Postprandial Glycemia

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