@article{2c2577e0072d11df825d000ea68e967b,
title = "Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17",
abstract = "Peroral infection with Toxoplasma gondii leads to the development of small intestinal inflammation dependent on Th1 cytokines. The role of Th17 cells in ileitis is unknown. We report interleukin (IL)-23-mediated gelatinase A (matrixmetalloproteinase [MMP]-2) up-regulation in the ileum of infected mice. MMP-2 deficiency as well as therapeutic or prophylactic selective gelatinase blockage protected mice from the development of T. gondii-induced immunopathology. Moreover, IL-23-dependent up-regulation of IL-22 was essential for the development of ileitis, whereas IL-17 was down-regulated and dispensable. CD4(+) T cells were the main source of IL-22 in the small intestinal lamina propria. Thus, IL-23 regulates small intestinal inflammation via IL-22 but independent of IL-17. Gelatinases may be useful targets for treatment of intestinal inflammation.",
author = "Melba Mu{\~n}oz and Heimesaat, {Markus M} and Kerstin Danker and Daniela Struck and Uwe Lohmann and Rita Plickert and Stefan Bereswill and Andr{\'e} Fischer and Dunay, {Ildik{\`o} Rita} and Kerstin Wolk and Christoph Loddenkemper and Hans-Willi Krell and Claude Libert and Lund, {Leif R} and Oliver Frey and Christoph H{\"o}lscher and Yoichiro Iwakura and Nico Ghilardi and Wenjun Ouyang and Thomas Kamradt and Robert Sabat and Oliver Liesenfeld",
note = "Keywords: Animals; Female; Interleukin-17; Interleukin-23; Interleukins; Intestine, Small; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Piperazines; Pyrimidines; Toxoplasma; Toxoplasmosis, Animal",
year = "2009",
doi = "10.1084/jem.20090900",
language = "English",
volume = "206",
pages = "3047--59",
journal = "The Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "13",
}