TY - JOUR
T1 - Interface mechanics and histomorphometric analysis of hydroxyapatite-coated and porous glass-ceramic implants in canine bone
AU - Nimb, L
AU - Jensen, J S
AU - Gotfredsen, K
N1 - Keywords: Alloys; Animals; Bone Remodeling; Bone Substitutes; Bone and Bones; Ceramics; Dogs; Female; Femur; Growth Plate; Hydroxyapatites; Materials Testing; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Osseointegration; Prostheses and Implants; Surface Properties; Titanium
PY - 1995
Y1 - 1995
N2 - A canine study was performed to make a histological and biomechanical evaluation of the interface between bone and two different bioceramic implants. A newly developed glass-ceramic formed by P2O5, CaO, SiO2, and Al2O3, giving a crystal phase composed of CaP2O6-AlPO4-SiP2O7, was compared to hydroxyapatite (HA) coated Ti-6Al-4V implants. A total of 24 implants were inserted into the femoral condyle of 15 adult female golden retriever dogs weighing 20-25 kg. There was a 12 week follow-up. Implants were examined by mechanical testing, histology, histomorphometry, microradiograpic methods, and EDAX analysis. The ultimate shear strength for the HA-coated implants was significantly higher than in the glass-ceramic group. When these values were related to the histomorphometric measurements, the difference could be explained by the tissue-to-implant contact. The glass-ceramic showed direct contact only with nonmineralized, osteoid bone. The HA-coated implants, however, were integrated into the bone. The study indicated that porous glass-ceramic containing AlPO4 causes local osteomalacia and might not be suitable for clinical purposes.
AB - A canine study was performed to make a histological and biomechanical evaluation of the interface between bone and two different bioceramic implants. A newly developed glass-ceramic formed by P2O5, CaO, SiO2, and Al2O3, giving a crystal phase composed of CaP2O6-AlPO4-SiP2O7, was compared to hydroxyapatite (HA) coated Ti-6Al-4V implants. A total of 24 implants were inserted into the femoral condyle of 15 adult female golden retriever dogs weighing 20-25 kg. There was a 12 week follow-up. Implants were examined by mechanical testing, histology, histomorphometry, microradiograpic methods, and EDAX analysis. The ultimate shear strength for the HA-coated implants was significantly higher than in the glass-ceramic group. When these values were related to the histomorphometric measurements, the difference could be explained by the tissue-to-implant contact. The glass-ceramic showed direct contact only with nonmineralized, osteoid bone. The HA-coated implants, however, were integrated into the bone. The study indicated that porous glass-ceramic containing AlPO4 causes local osteomalacia and might not be suitable for clinical purposes.
U2 - 10.1002/jbm.820291203
DO - 10.1002/jbm.820291203
M3 - Journal article
C2 - 8600137
SN - 0021-9304
VL - 29
SP - 1477
EP - 1482
JO - Journal of Biomedical Materials Research
JF - Journal of Biomedical Materials Research
IS - 12
ER -