TY - JOUR
T1 - Interethnic analyses of blood pressure loci in populations of East Asian and European descent
AU - Takeuchi, Fumihiko
AU - Akiyama, Masato
AU - Matoba, Nana
AU - Katsuya, Tomohiro
AU - Nakatochi, Masahiro
AU - Tabara, Yasuharu
AU - Narita, Akira
AU - Saw, Woei Yuh
AU - Moon, Sanghoon
AU - Spracklen, Cassandra N.
AU - Chai, Jin Fang
AU - Kim, Young Jin
AU - Zhang, Liang
AU - Wang, Chaolong
AU - Li, Huaixing
AU - Li, Honglan
AU - Wu, Jer Yuarn
AU - Dorajoo, Rajkumar
AU - Nierenberg, Jovia L.
AU - Wang, Ya Xing
AU - He, Jing
AU - Bennett, Derrick A.
AU - Takahashi, Atsushi
AU - Momozawa, Yukihide
AU - Hirata, Makoto
AU - Matsuda, Koichi
AU - Rakugi, Hiromi
AU - Nakashima, Eitaro
AU - Isono, Masato
AU - Shirota, Matsuyuki
AU - Hozawa, Atsushi
AU - Ichihara, Sahoko
AU - Matsubara, Tatsuaki
AU - Yamamoto, Ken
AU - Kohara, Katsuhiko
AU - Igase, Michiya
AU - Han, Sohee
AU - Gordon-Larsen, Penny
AU - Huang, Wei
AU - Lee, Nanette R.
AU - Adair, Linda S.
AU - Hwang, Mi Yeong
AU - Ahluwalia, Tarunveer S.
AU - Grarup, Niels
AU - Husemoen, Lise L.N.
AU - Justesen, Johanne M.
AU - Hansen, Torben
AU - Jørgensen, Torben
AU - Linneberg, Allan
AU - Pedersen, Oluf
AU - The International Genomics of Blood Pressure (iGEN-BP) Consortium
PY - 2018
Y1 - 2018
N2 - Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.
AB - Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.
U2 - 10.1038/s41467-018-07345-0
DO - 10.1038/s41467-018-07345-0
M3 - Journal article
C2 - 30487518
AN - SCOPUS:85057523899
SN - 2041-1723
VL - 9
JO - Nature Communications
JF - Nature Communications
M1 - 5052
ER -
