Interaction of different forms of graphene with chicken embryo red blood cells

S. Jaworski; Mateusz Hinzmann; Ewa Sawosz; Marta Grodzik; Marta Kutwin; Mateusz Wierzbicki; B Strojny; Krishna Prasad Vadalasetty; Ludwika Lipińska; André Chwalibog

doi:10.1007/s11356-017-9788-5

Interaction of different forms of graphene with chicken embryo red blood cells

S. Jaworski, Mateusz Hinzmann, Ewa Sawosz, Marta Grodzik, Marta Kutwin, Mateusz Wierzbicki, B Strojny, Krishna Prasad Vadalasetty, Ludwika Lipińska, André Chwalibog

9 Citationer (Scopus)

56 Downloads (Pure)

Abstract

With the rapid development of graphene synthesis and functionalization approaches, graphene and its related derivatives have shown great potential in many applications in material science, including biomedical applications. Several in vitro and in vivo studies clearly showed no definitive risks, while others have indicated that graphene might become health hazards. In this study, we explore the biocompatibility of graphene-related materials with chicken embryo red blood cells (RBC). The hemolysis assay was employed to evaluate the in vitro blood compatibility of reduced graphene, graphene oxide, and reduced graphene oxide, because these materials have recently been used for biomedical applications, including injectable graphene-related particles. This study investigated structural damage, ROS production and hemolysis of chicken embryo red blood cells. Different forms of graphene, when incubated with chicken embryo RBC, were harmful to cell structure and induced hemolysis.

Originalsprog	Engelsk
Tidsskrift	Environmental Science and Pollution Research
Vol/bind	24
Udgave nummer	27
Sider (fra-til)	21671–21679
Antal sider	9
ISSN	0944-1344
DOI	https://doi.org/10.1007/s11356-017-9788-5
Status	Udgivet - 1 sep. 2017

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10.1007/s11356-017-9788-5Licens: CC BY

Interaction of different forms of graphene with chicken embryo red blood cellsForlagets udgivne version, 1,68 MBLicens: CC BY

Citationsformater

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title = "Interaction of different forms of graphene with chicken embryo red blood cells",

abstract = "With the rapid development of graphene synthesis and functionalization approaches, graphene and its related derivatives have shown great potential in many applications in material science, including biomedical applications. Several in vitro and in vivo studies clearly showed no definitive risks, while others have indicated that graphene might become health hazards. In this study, we explore the biocompatibility of graphene-related materials with chicken embryo red blood cells (RBC). The hemolysis assay was employed to evaluate the in vitro blood compatibility of reduced graphene, graphene oxide, and reduced graphene oxide, because these materials have recently been used for biomedical applications, including injectable graphene-related particles. This study investigated structural damage, ROS production and hemolysis of chicken embryo red blood cells. Different forms of graphene, when incubated with chicken embryo RBC, were harmful to cell structure and induced hemolysis.",

author = "S. Jaworski and Mateusz Hinzmann and Ewa Sawosz and Marta Grodzik and Marta Kutwin and Mateusz Wierzbicki and B Strojny and Vadalasetty, {Krishna Prasad} and Ludwika Lipi{\'n}ska and Andr{\'e} Chwalibog",

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T1 - Interaction of different forms of graphene with chicken embryo red blood cells

AU - Jaworski, S.

AU - Hinzmann, Mateusz

AU - Sawosz, Ewa

AU - Grodzik, Marta

AU - Kutwin, Marta

AU - Wierzbicki, Mateusz

AU - Strojny, B

AU - Vadalasetty, Krishna Prasad

AU - Lipińska, Ludwika

AU - Chwalibog, André

PY - 2017/9/1

Y1 - 2017/9/1

N2 - With the rapid development of graphene synthesis and functionalization approaches, graphene and its related derivatives have shown great potential in many applications in material science, including biomedical applications. Several in vitro and in vivo studies clearly showed no definitive risks, while others have indicated that graphene might become health hazards. In this study, we explore the biocompatibility of graphene-related materials with chicken embryo red blood cells (RBC). The hemolysis assay was employed to evaluate the in vitro blood compatibility of reduced graphene, graphene oxide, and reduced graphene oxide, because these materials have recently been used for biomedical applications, including injectable graphene-related particles. This study investigated structural damage, ROS production and hemolysis of chicken embryo red blood cells. Different forms of graphene, when incubated with chicken embryo RBC, were harmful to cell structure and induced hemolysis.

AB - With the rapid development of graphene synthesis and functionalization approaches, graphene and its related derivatives have shown great potential in many applications in material science, including biomedical applications. Several in vitro and in vivo studies clearly showed no definitive risks, while others have indicated that graphene might become health hazards. In this study, we explore the biocompatibility of graphene-related materials with chicken embryo red blood cells (RBC). The hemolysis assay was employed to evaluate the in vitro blood compatibility of reduced graphene, graphene oxide, and reduced graphene oxide, because these materials have recently been used for biomedical applications, including injectable graphene-related particles. This study investigated structural damage, ROS production and hemolysis of chicken embryo red blood cells. Different forms of graphene, when incubated with chicken embryo RBC, were harmful to cell structure and induced hemolysis.

U2 - 10.1007/s11356-017-9788-5

DO - 10.1007/s11356-017-9788-5

M3 - Journal article

C2 - 28755146

SN - 0944-1344

VL - 24

SP - 21671

EP - 21679

JO - Environmental Science and Pollution Research

JF - Environmental Science and Pollution Research

IS - 27

ER -

Interaction of different forms of graphene with chicken embryo red blood cells

Abstract

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