TY - JOUR
T1 - Inter-Scan Reproducibility of Carotid Plaque Volume Measurements by 3-D Ultrasound
AU - Sandholt, Benjamin V
AU - Collet-Billon, Antoine
AU - Entrekin, Robert
AU - Sillesen, Henrik H
N1 - Copyright © 2018 World Federation for Ultrasound in Medicine and Biology. Published by Elsevier Inc. All rights reserved.
PY - 2018/3
Y1 - 2018/3
N2 - We tested a novel 3-D matrix transducer with respect to inter-scan reproducibility of carotid maximum plaque thickness (MPT) and volume measurements. To improve reproducibility while focusing on the largest plaque/most diseased part of the carotid artery, we introduced a new partial plaque volume (PPV) measure centered on MPT. Total plaque volume (TPV), PPV from a 10-mm segment and MPT were measured using dedicated semi-automated software on 38 plaques from 26 patients. Inter-scan reproducibility was assessed using the t-test, Bland-Altman plots and Pearson's correlation coefficient. There was a mean difference of 0.01 mm in MPT (limits of agreement: -0.45 to 0.42 mm, Pearson's correlation coefficient: 0.96). Both volume measurements exhibited high reproducibility, with PPV being superior (limits of agreement: -35.3 mm3 to 33.5 mm3, Pearson's correlation coefficient: 0.96) to TPV (limits of agreement: -88.2 to 61.5 mm3, Pearson's correlation coefficient: 0.91). The good reproducibility revealed by the present results encourages future studies on establishing plaque quantification as part of cardiovascular risk assessment and for follow-up of disease progression over time.
AB - We tested a novel 3-D matrix transducer with respect to inter-scan reproducibility of carotid maximum plaque thickness (MPT) and volume measurements. To improve reproducibility while focusing on the largest plaque/most diseased part of the carotid artery, we introduced a new partial plaque volume (PPV) measure centered on MPT. Total plaque volume (TPV), PPV from a 10-mm segment and MPT were measured using dedicated semi-automated software on 38 plaques from 26 patients. Inter-scan reproducibility was assessed using the t-test, Bland-Altman plots and Pearson's correlation coefficient. There was a mean difference of 0.01 mm in MPT (limits of agreement: -0.45 to 0.42 mm, Pearson's correlation coefficient: 0.96). Both volume measurements exhibited high reproducibility, with PPV being superior (limits of agreement: -35.3 mm3 to 33.5 mm3, Pearson's correlation coefficient: 0.96) to TPV (limits of agreement: -88.2 to 61.5 mm3, Pearson's correlation coefficient: 0.91). The good reproducibility revealed by the present results encourages future studies on establishing plaque quantification as part of cardiovascular risk assessment and for follow-up of disease progression over time.
KW - Aged
KW - Aged, 80 and over
KW - Carotid Arteries/diagnostic imaging
KW - Carotid Stenosis/diagnostic imaging
KW - Female
KW - Humans
KW - Imaging, Three-Dimensional/methods
KW - Male
KW - Middle Aged
KW - Plaque, Atherosclerotic/diagnostic imaging
KW - Reproducibility of Results
KW - Ultrasonography/methods
U2 - 10.1016/j.ultrasmedbio.2017.10.018
DO - 10.1016/j.ultrasmedbio.2017.10.018
M3 - Journal article
C2 - 29284557
SN - 0301-5629
VL - 44
SP - 670
EP - 676
JO - Ultrasound in Medicine & Biology
JF - Ultrasound in Medicine & Biology
IS - 3
ER -