TY - JOUR
T1 - Intact mammalian cell function on semi-conductor nanowire arrays: new perspectives for cell-based biosensing
T2 - New Perspectives for Cell-Based
AU - Berthing, Trine
AU - Bonde, Sara
AU - Sørensen, Claus Birger
AU - Utko, Pawel Wincenty
AU - Nygård, Jesper
AU - Martinez, Karen Laurence
PY - 2011/3/7
Y1 - 2011/3/7
N2 - Nanowires (NWs) are attracting more and more interest due to their potential cellular applications, such as delivery of compounds or sensing platforms. Arrays of vertical indium-arsenide (InAs) NWs are interfaced with human embryonic kidney cells and rat embryonic dorsal root ganglion neurons. A selection of critical cell functions and pathways are shown not to be impaired, including cell adhesion, membrane integrity, intracellular enzyme activity, DNA uptake, cytosolic and membrane protein expression, and the neuronal maturation pathway. The results demonstrate the low invasiveness of InAs NW arrays, which, combined with the unique physical properties of InAs, open up their potential for cellular investigations.
AB - Nanowires (NWs) are attracting more and more interest due to their potential cellular applications, such as delivery of compounds or sensing platforms. Arrays of vertical indium-arsenide (InAs) NWs are interfaced with human embryonic kidney cells and rat embryonic dorsal root ganglion neurons. A selection of critical cell functions and pathways are shown not to be impaired, including cell adhesion, membrane integrity, intracellular enzyme activity, DNA uptake, cytosolic and membrane protein expression, and the neuronal maturation pathway. The results demonstrate the low invasiveness of InAs NW arrays, which, combined with the unique physical properties of InAs, open up their potential for cellular investigations.
U2 - 10.1002/smll.201001642
DO - 10.1002/smll.201001642
M3 - Journal article
C2 - 21290597
SN - 1613-6810
VL - 7
SP - 640
EP - 647
JO - Small
JF - Small
IS - 6
ER -