Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle

Atul S Deshmukh

doi:10.1515/hmbci-2015-0041

Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle

21 Citationer (Scopus)

Abstract

Skeletal muscle is the largest tissues in the human body and is considered the primary target for insulin-stimulated glucose disposal. In skeletal muscle, binding of the insulin to insulin receptor (IR) initiates a signaling cascade that results in the translocation of the insulin-sensitive glucose transporter protein 4 (GLUT4) to the plasma membrane which leads to facilitated diffusion of glucose into the cell. Understanding the precise signaling events guiding insulin-stimulated glucose uptake is pivotal, because impairment in these signaling events leads to development of insulin resistance and type 2 diabetes. This review summarizes current understanding of insulin signaling pathways mediating glucose uptake in healthy and insulin-resistant skeletal muscle.

Originalsprog	Engelsk
Tidsskrift	Hormone Molecular Biology and Clinical Investigation
Vol/bind	26
Udgave nummer	1
Sider (fra-til)	13-24
Antal sider	12
ISSN	1868-1883
DOI	https://doi.org/10.1515/hmbci-2015-0041
Status	Udgivet - 1 apr. 2016

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Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle

Abstract

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