Insulin-like growth factor I receptor density on CD4+T-lymphocytes from active early steroid- and DMARD-naïve rheumatoid arthritis patients is up-regulated and not influenced by 1 year of clinically effective treatment

Trine Bay Laurberg; Torkell Juulsgaad Ellingsen; Jonas Thorsen; Bjarne Kuno Møller; Ib Tønder Hansen; Ulrik Tarp; Merete Lund Hetland; Kim Hørslev-Petersen; Allan Flyvbjerg; Jan Frystyk; Kristian Stengaard-Pedersen

doi:10.1007/s00296-010-1683-z

Insulin-like growth factor I receptor density on CD4+T-lymphocytes from active early steroid- and DMARD-naïve rheumatoid arthritis patients is up-regulated and not influenced by 1 year of clinically effective treatment

Trine Bay Laurberg, Torkell Juulsgaad Ellingsen, Jonas Thorsen, Bjarne Kuno Møller, Ib Tønder Hansen, Ulrik Tarp, Merete Lund Hetland, Kim Hørslev-Petersen, Allan Flyvbjerg, Jan Frystyk, Kristian Stengaard-Pedersen

Institut for Klinisk Medicin

7 Citationer (Scopus)

Abstract

The IGF-IR density on CD4+T-lymphocytes was studied using flow cytometry in 40 early steroid- and DMARD-naïve rheumatoid arthritis (RA) patients before and after 52 weeks of treatment with methotrexate+placebo or methotrexate+cyclosporine A and in 15 controls. RA patients had increased IGF-IR density on CD4+T-lymphocytes at week 0 and week 52, irrespective of treatment. IGF-IR-positive CD4+T-lymphocytes fraction decreased during treatment, but neither at week 0 nor at week 52 did it differ from healthy controls. No correlations were found to disease activity parameters.

Originalsprog	Engelsk
Tidsskrift	Rheumatology International
Vol/bind	32
Udgave nummer	2
Sider (fra-til)	501-4
Antal sider	4
ISSN	0172-8172
DOI	https://doi.org/10.1007/s00296-010-1683-z
Status	Udgivet - feb. 2012

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10.1007/s00296-010-1683-z

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Citationsformater

Laurberg, T. B., Ellingsen, T. J., Thorsen, J., Møller, B. K., Hansen, I. T., Tarp, U., Hetland, M. L., Hørslev-Petersen, K., Flyvbjerg, A., Frystyk, J., & Stengaard-Pedersen, K. (2012). Insulin-like growth factor I receptor density on CD4+T-lymphocytes from active early steroid- and DMARD-naïve rheumatoid arthritis patients is up-regulated and not influenced by 1 year of clinically effective treatment. Rheumatology International, 32(2), 501-4. https://doi.org/10.1007/s00296-010-1683-z

Insulin-like growth factor I receptor density on CD4+T-lymphocytes from active early steroid- and DMARD-naïve rheumatoid arthritis patients is up-regulated and not influenced by 1 year of clinically effective treatment. / Laurberg, Trine Bay; Ellingsen, Torkell Juulsgaad; Thorsen, Jonas et al.

I: Rheumatology International, Bind 32, Nr. 2, 02.2012, s. 501-4.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Laurberg, TB, Ellingsen, TJ, Thorsen, J, Møller, BK, Hansen, IT, Tarp, U, Hetland, ML, Hørslev-Petersen, K, Flyvbjerg, A, Frystyk, J & Stengaard-Pedersen, K 2012, 'Insulin-like growth factor I receptor density on CD4+T-lymphocytes from active early steroid- and DMARD-naïve rheumatoid arthritis patients is up-regulated and not influenced by 1 year of clinically effective treatment', Rheumatology International, bind 32, nr. 2, s. 501-4. https://doi.org/10.1007/s00296-010-1683-z

Laurberg TB, Ellingsen TJ, Thorsen J, Møller BK, Hansen IT, Tarp U et al. Insulin-like growth factor I receptor density on CD4+T-lymphocytes from active early steroid- and DMARD-naïve rheumatoid arthritis patients is up-regulated and not influenced by 1 year of clinically effective treatment. Rheumatology International. 2012 feb.;32(2):501-4. doi: 10.1007/s00296-010-1683-z

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title = "Insulin-like growth factor I receptor density on CD4+T-lymphocytes from active early steroid- and DMARD-na{\"i}ve rheumatoid arthritis patients is up-regulated and not influenced by 1 year of clinically effective treatment",

abstract = "The IGF-IR density on CD4+T-lymphocytes was studied using flow cytometry in 40 early steroid- and DMARD-na{\"i}ve rheumatoid arthritis (RA) patients before and after 52 weeks of treatment with methotrexate+placebo or methotrexate+cyclosporine A and in 15 controls. RA patients had increased IGF-IR density on CD4+T-lymphocytes at week 0 and week 52, irrespective of treatment. IGF-IR-positive CD4+T-lymphocytes fraction decreased during treatment, but neither at week 0 nor at week 52 did it differ from healthy controls. No correlations were found to disease activity parameters.",

author = "Laurberg, {Trine Bay} and Ellingsen, {Torkell Juulsgaad} and Jonas Thorsen and M{\o}ller, {Bjarne Kuno} and Hansen, {Ib T{\o}nder} and Ulrik Tarp and Hetland, {Merete Lund} and Kim H{\o}rslev-Petersen and Allan Flyvbjerg and Jan Frystyk and Kristian Stengaard-Pedersen",

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doi = "10.1007/s00296-010-1683-z",

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T1 - Insulin-like growth factor I receptor density on CD4+T-lymphocytes from active early steroid- and DMARD-naïve rheumatoid arthritis patients is up-regulated and not influenced by 1 year of clinically effective treatment

AU - Laurberg, Trine Bay

AU - Ellingsen, Torkell Juulsgaad

AU - Thorsen, Jonas

AU - Møller, Bjarne Kuno

AU - Hansen, Ib Tønder

AU - Tarp, Ulrik

AU - Hetland, Merete Lund

AU - Hørslev-Petersen, Kim

AU - Flyvbjerg, Allan

AU - Frystyk, Jan

AU - Stengaard-Pedersen, Kristian

PY - 2012/2

Y1 - 2012/2

N2 - The IGF-IR density on CD4+T-lymphocytes was studied using flow cytometry in 40 early steroid- and DMARD-naïve rheumatoid arthritis (RA) patients before and after 52 weeks of treatment with methotrexate+placebo or methotrexate+cyclosporine A and in 15 controls. RA patients had increased IGF-IR density on CD4+T-lymphocytes at week 0 and week 52, irrespective of treatment. IGF-IR-positive CD4+T-lymphocytes fraction decreased during treatment, but neither at week 0 nor at week 52 did it differ from healthy controls. No correlations were found to disease activity parameters.

AB - The IGF-IR density on CD4+T-lymphocytes was studied using flow cytometry in 40 early steroid- and DMARD-naïve rheumatoid arthritis (RA) patients before and after 52 weeks of treatment with methotrexate+placebo or methotrexate+cyclosporine A and in 15 controls. RA patients had increased IGF-IR density on CD4+T-lymphocytes at week 0 and week 52, irrespective of treatment. IGF-IR-positive CD4+T-lymphocytes fraction decreased during treatment, but neither at week 0 nor at week 52 did it differ from healthy controls. No correlations were found to disease activity parameters.

U2 - 10.1007/s00296-010-1683-z

DO - 10.1007/s00296-010-1683-z

M3 - Journal article

C2 - 21246373

SN - 0172-8172

VL - 32

SP - 501

EP - 504

JO - Rheumatology International

JF - Rheumatology International

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